4 research outputs found
GuĂa integral digital para la elaboraciĂłn y (auto)evaluaciĂłn del Trabajo de Fin de Grado en lenguas, literaturas y culturas modernas
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The Literature of the Grandchildren of NS Criminals as Milestone in the Culture of Memory
Vor etwa zehn Jahren, eine lange Zeit schweigende Generation begann, sich zu Wort zu melden: es handelt sich um die Enkel der NS-Verbrecher. In ihren Werken beschrĂ€nken sie sich nicht darauf, die Verbrechen ihrer GroĂeltern zu verurteilen, sondern helfen uns, die Entwicklung der deutschen Gesellschaft in den letzten Jahren zu verstehen, und auch warum der Zweite Weltkrieg immer noch eine so wichtige Rolle in der soziopolitischen Ordnung dieses Landes spielt. In dieser Arbeit werden vier autobiographische BĂŒcher analysiert, in denen ihre Autoren (Alexandra Senfft, Jennifer Teege, Uwe von Seltmann und Rudolf Höss), alle Enkel von hochrangigen Nazis, ĂŒber die Vergangenheitsaufarbeitung ihrer jeweiligen Familien sprechen. Damit wird es versucht herauszufinden, ob sie einen neuen Meilenstein in der Erinnerungskultur darstellen.Desde hace aproximadamente una dĂ©cada, una generaciĂłn que habĂa permanecido durante largo tiempo en silencio empezĂł a manifestarse literariamente: se trata de los nietos de los verdugos nazis. Lejos de limitarse a condenar los crĂmenes de sus abuelos, su perspectiva Ășnica nos ayuda a comprender la evoluciĂłn de la sociedad alemana en los Ășltimos años y por quĂ© la Segunda Guerra Mundial aĂșn juega un papel tan importante en la configuraciĂłn sociopolĂtica de este paĂs. En este trabajo se analizan cuatro obras de carĂĄcter testimonial en las que sus autores (Alexandra Senfft, Jennifer Teege, Uwe von Seltmann y Rudolf Höss), todos ellos nietos de altos cargos nazis, hablan sobre el enfrentamiento con su pasado familiar, con el objetivo de examinar en quĂ© medida pueden ser consideradas como un nuevo hito en la cultura de la memoria.About ten years ago, a generation that had remained silent for a long time started to speak out, namely, the grandchildren of the Nazi executioners. Far from simply condemning their grandparentsâ crimes, their unique perspective helps us to understand the evolution of German society in the past few years and why Second World War still plays such an important role in the sociopolitical configuration of this country. In this work will be analyzed four autobiographic works in which their authors (Alexandra Senfft, Jennifer Teege, Uwe von Seltmann and Rudolf Höss), all of them grandchildren of high-ranking Nazis, speak about the confrontation with their family past, with the objective of studying to what extent they constitute a new milestone in the culture of remembrance.Depto. de FilologĂa Alemana y FilologĂa EslavaFac. de FilologĂaTRUEunpu
Assessment of plasma chitotriosidase activity, CCL18/PARC concentration and NP-C suspicion index in the diagnosis of Niemann-Pick disease type C : A prospective observational study
Niemann-Pick disease type C (NP-C) is a rare, autosomal recessive neurodegenerative disease caused by mutations in either the NPC1 or NPC2 genes. The diagnosis of NP-C remains challenging due to the non-specific, heterogeneous nature of signs/symptoms. This study assessed the utility of plasma chitotriosidase (ChT) and Chemokine (C-C motif) ligand 18 (CCL18)/pulmonary and activation-regulated chemokine (PARC) in conjunction with the NP-C suspicion index (NP-C SI) for guiding confirmatory laboratory testing in patients with suspected NP-C. In a prospective observational cohort study, incorporating a retrospective determination of NP-C SI scores, two different diagnostic approaches were applied in two separate groups of unrelated patients from 51 Spanish medical centers (n = 118 in both groups). From Jan 2010 to Apr 2012 (Period 1), patients with â„2 clinical signs/symptoms of NP-C were considered 'suspected NP-C' cases, and NPC1/NPC2 sequencing, plasma chitotriosidase (ChT), CCL18/PARC and sphingomyelinase levels were assessed. Based on findings in Period 1, plasma ChT and CCL18/PARC, and NP-C SI prediction scores were determined in a second group of patients between May 2012 and Apr 2014 (Period 2), and NPC1 and NPC2 were sequenced only in those with elevated ChT and/or elevated CCL18/PARC and/or NP-C SI â„70. Filipin staining and 7-ketocholesterol (7-KC) measurements were performed in all patients with NP-C gene mutations, where possible. In total across Periods 1 and 2, 10/236 (4%) patients had a confirmed diagnosis o NP-C based on gene sequencing (5/118 [4.2%] in each Period): all of these patients had two causal NPC1 mutations. Single mutant NPC1 alleles were detected in 8/236 (3%) patients, overall. Positive filipin staining results comprised three classical and five variant biochemical phenotypes. No NPC2 mutations were detected. All patients with NPC1 mutations had high ChT activity, high CCL18/PARC concentrations and/or NP-C SI scores â„70. Plasma 7-KC was higher than control cut-off values in all patients with two NPC1 mutations, and in the majority of patients with single mutations. Family studies identified three further NP-C patients. This approach may be very useful for laboratories that do not have mass spectrometry facilities and therefore, they cannot use other NP-C biomarkers for diagnosis