Analysis of genomic copy number variations through whole-genome scan in Chinese Qaidam cattle

Qaidam cattle (CDM) are indigenous breed inhabiting Northwest China. In the present study, we newly sequenced 20 Qaidam cattle to investigate the copy number variants (CNVs) based on the ARS-UMD1.2 reference genome. We generated the CNV region (CNVR) datasets to explore the genomic CNV diversity and population stratification. The other four cattle breeds (Xizang cattle, XZ; Kazakh cattle, HSK; Mongolian cattle, MG; and Yanbian cattle, YB) from the regions of North China embracing 43 genomic sequences were collected and are distinguished from each of the other diverse populations by deletions and duplications. We also observed that the number of duplications was significantly more than deletions in the genome, which may be less harmful to gene formation and function. At the same time, only 1.15% of CNVRs overlapped with the exon region. Population differential CNVRs and functional annotations between the Qaidam cattle population and other cattle breeds revealed the functional genes related to immunity (MUC6), growth (ADAMTSL3), and adaptability (EBF2). Our analysis has provided numerous genomic characteristics of some Chinese cattle breeds, which are valuable as customized biological molecular markers in cattle breeding and production

Effects of aerobic combined with resistance exercise on cardiorespiratory fitness and cardiometabolic health in breast cancer survivors: A Systematic Review, meta-analysis and meta-regression

Background: Cardiotoxicity from chemotherapy is a serious risk to the quality of survival of breast cancer survivors (BCS), and aerobic combined with resistance exercise (CE) has the potential to combat this cardiac damage. However, there is a lack of high-quality studies to assess the specific effects of CE. This study aimed to investigate the effects of CE on cardiopulmonary function (CRF) and cardiometabolic health in BCS. Methods: A comprehensively searched of the 4 databases (PubMed, Embase, Web of Science, Cochrane Library) from the database construction until March 1, 2023. The included studies were randomized controlled trials (RCTs) reporting the effects of CE on CRF and cardiometabolic health in BCS. The quality of the literature was assessed by two independent reviewers using the Cochrane Collaboration Risk of Bias Tool. Weight means difference (WMD), or standardized mean difference (SMD), were combined using random or fixed effects models. Subgroup and meta-regression explored heterogeneity as well as covariate effects. Results: 40 studies were included in the meta-analysis, with 2849 participants. Results showed that CE significantly increased maximal oxygen uptake (VO2max) (WMD:4.55; 95% CI:2.84, 6.26; I2 = 91.90%, P < 0.001) and reduced body weight (BW) (WMD: 1.61; 95% CI: 2.44, −0.78; I2 = 38.60%, P = 0.032) and body mass index (BMI) (WMD: 0.86; 95% CI: 1.43, −0.29; I2 = 70.50%, P < 0.001) in BCS. Subgroup analysis showed that BMI (WMD: 1.15; 95% CI: 1.89, −0.41; I2 = 76.90%, P < 0.001) and VO2max (WMD:4.21; 95% CI:2.40, 6.02; I2 = 96.4%, P < 0.001) were more effective with supervision. Meta-regression analysis showed that sample size had a significant moderating effect on BW (Coeff: 0.03, 95% CI: 0.00, 0.06). Conclusions: CE significantly increases CRF in BCS and improves most cardiometabolic health-related outcomes. In addition, there will be a need for many larger RCTs to explore the effects of CE on inflammatory biomarkers in BCS

A Retrospective Study on Risk Factors for Urinary Tract Infection in Patients with Intracranial Cerebral Hemorrhage

Objective. This study aimed to explore the risk factors of urinary tract infection (UTI) in patients with intracranial cerebral hemorrhage (ICH). Design. This is a retrospective study, and a total of 77 patients with ICH consecutively admitted to the First Affiliated Hospital of USTC (Anhui Provincial Hospital, Hefei, China) during the period of August 2015 to August 2017 were included. The patients were divided into an UTI group (24 cases) and a non-UTI group (53 cases); patients with UTI were diagnosed according to clinical manifestations, recent urinary routines, and urine culture results. The following information in these two groups was recorded: age, sex, course of disease, side of paralysis, location and type of cerebral hemorrhage, disturbance of consciousness or not, the Brunnstrom stage of paralysed lower limbs, number of basic diseases, whether there were complications (tracheotomy, retention catheterization, pulmonary infection, pressure sore, deep venous thrombosis, etc.), whether rehabilitation interventions were conducted, blood routine, biochemistry index, DIC complete set, urine routine, and urine culture data. Univariate analysis and multivariate logistic regression analysis were used to examine the risk factors of UTI in patients with ICH. Results. Univariate analysis showed that age, side of paralysis, disturbance of consciousness, the Brunnstrom stage of lower limbs, tracheotomies, retention catheterization, pulmonary infection, leukocyte count, neutrophil proportion, sodium, uric acid, D-dimer, and fibrinogen may be related to UTI in patients with ICH (P<0.05). Regression analysis showed that age (OR (95% CI) = 1.207 (1.022–1.424), P=0.026), right-sided paralysis (OR (95% CI) = 0.20 (0.001–0.650), P=0.028), and D-dimer (OR (95% CI) = 1.403 (1.003–1.961), P=0.048) were associated with UTI in ICH patients. Conclusions. Increased age and high D-dimer are independent risk factors for UTI in patients with ICH, while right-sided paralysis is a protective factor for UTI in patients with ICH

A High Responsivity and Photosensitivity Self‐Powered UV Photodetector Constructed by the CuZnS/Ga2O3 Heterojunction

Abstract Fabricating a heterojunction photodetector is efficient to take advantage of the built‐in electric field formed by heterojunction and thus improve the performance of photodetector. Herein, a CuZnS/Ga2O3 type‐II heterojunction photodetector is designed and constructed by chemical bath deposition for the first time. The photodetector exhibits super high rectifying characteristics (5.7 × 104 at ± 1 V), high responsivity (48.01 mA W−1 at 0 V), and detectivity (1.83 × 1012 Jones at 0 V), which are higher than most of the reported inorganic devices as far as the authors know. Benefiting from built‐in electric field constructed by the CuZnS/Ga2O3 type‐II heterojunction, the photo‐induced electron and hole pairs are quickly separated by the built‐in electric field between the Ga2O3 and the CuZnS interface. Therefore, the photodetector constructed by CuZnS/Ga2O3 type‐II heterojunction shows a prominent self‐powered performance. At zero bias, the photodetector shows a fast photoresponse (rise time τr = 70 ms, decay time τd = 10 ms). These data of performance are significantly excellent to most of the reported Ga2O3 heterojunction photodetectors. These performances strongly suggest that the CuZnS/Ga2O3 photodetector has great potential in ultra‐high performance self‐powered solar‐blind photodetector

Spectroscopy and diode pumped laser emission in (Lu<inf>x</inf> Gd<inf>(1-x)</inf>)<inf>3</inf> Ga<inf>5</inf>O<inf>12</inf>:Tm³⁺ single crystal

We report on the first laser emission of (Lux Gd(1-x))3 Ga5O12 doped with Tm3+ ions obtaining a slope efficiency of 20% and a maximum output power of 170 mW centered at 2013 nm. Evidences of a multiline emission are shown. Moreover a spectroscopic investigation on six samples of (Lux Gd(1-x))3 Ga5O12:Tm3+ having different Lu concentrations is presented. In particular the stark sublevels energy of 3H6 and 3F4 manifolds have been determined. Spectroscopic data have been utilized to calculate absorption and emission cross sections and gain curves

Temperature Dependence of the Thermal, Electrical Resistivity, Dielectric and Piezoelectric Properties of CaYAl3O7 Crystal

Calcium yttrium aluminate (CaYAl3O7) crystal was grown and characterized in detail for high temperature piezoelectric sensors for the first time. The thermal properties of the CaYAl3O7 (CYAM) crystal were investigated systematically. In particular, the CYAM crystal exhibits considerably high resistivity along X- and Z- direction in the order of 6.96 × 107 Ω·cm and 2.86 × 108 Ω·cm at 600 °C, respectively. The temperature dependence of the electromechanical properties of CYAM crystal were investigated over the temperature range of 25–500 °C. The high thermal stability of piezoelectric properties together with its high electrical resistivity, makes CaYAl3O7 crystal a promising candidate for high temperature piezoelectric applications

Enhancement Mode Ga2O3 Field Effect Transistor with Local Thinning Channel Layer

&beta;&minus;Ga2O3 field&minus;effect transistors (FETs) were fabricated with and without local thinning to change the threshold voltage. A 220 nm Ga2O3 layer was mechanically exfoliated from a Cr&minus;doped gallium oxide single crystal. Approximately 45 nm Ga2O3 was etched by inductively coupled plasma to form the local thinning. The threshold voltage of the device with etched local thinning increased from &minus;3 V to +7 V compared to the unetched device. The effect of the local thinning was analyzed by device simulation, confirming that the local thinning structure is an effective method to enable enhancement&minus;mode Ga2O3 FETs