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    Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

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    Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14路2 per cent (646 of 4544) and the 30-day mortality rate was 1路8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7路61, 95 per cent c.i. 4路49 to 12路90; P < 0路001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0路65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability

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    Not AvailableThe increasing demand for crop production, given worldwide increases in the human population, puts pressure on moving natural resources towards sus-tainable development. This creates a big challenge for the upcoming generation. If improvement is not successful, there exists the unfortunate consequence that global food production may soon become insufficient to feed all of the world鈥檚 people. It is therefore essential that agricultural productivity be significantly increased in a more sustainable and environmentally friendly approach. Plant-beneficiary rhizo-bacteria (PBR) naturally activate microorganisms found in the soil. Because they are inexpensive, effective, and environmentally friendly, PBR are gaining impor-tance for use in crop production by restoring the soil鈥檚 natural fertility and protect-ing it against drought and soil diseases, thereby stimulating plant growth. PBR decrease the use of chemical fertilisers, pesticides, and artificial growth regulators; the intensive use of these inputs has led to severe health and environmental hazards, such as soil erosion, water contamination, pesticide poisoning, decreased ground-water table, water logging, surface crusting and depletion of biodiversity. The use of PBR has been proven to be an environmentally sound way of increasing crop yields by facilitating plant growth through either a direct or indirect mechanism with the aim of sustaining soil health over the long term. (7) (PDF) Towards Plant-Beneficiary Rhizobacteria and Agricultural Sustainability. Available from: https://www.researchgate.net/publication/325854138_Towards_Plant-Beneficiary_Rhizobacteria_and_Agricultural_Sustainability [accessed Nov 19 2018].Not Availabl
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