Simple generalizations of Anti-de Sitter space-time

We consider new cosmological solutions which generalize the cosmological patch of the Anti-de Sitter (AdS) space-time, allowing for fluids with equations of state such that $w\neq -1$. We use them to derive the associated full manifolds. We find that these solutions can all be embedded in flat five-dimensional space-time with $--+++$ signature, revealing deformed hyperboloids. The topology and causal-structure of these spaces is therefore unchanged, and closed time-like curves are identified, before a covering space is considered. However the structure of Killing vector fields is entirely different and so we may expect a different structure of Killing horizons in these solutions.Comment: 6 Pages, 5 Figures, Corrections and additions made for publication in Journal of Classical and Quantum Gravit

Magnetic studies of Bi x Y3-x Fe5O12 fabricated using conventional method

A series of Bi substituted yttrium iron garnet (Bi-YIG) nanoparticles with nominal formula of BixY3 − xFe5O12 in which x varied in steps of 0.0, 0.25 and 0.5 are prepared by conventional method. Vibration sample magnetometer (VSM) at Room temperature (RT) shows saturation magnetization decreases from 27.4 to 25.2 (emu/g) as x value increases from 0.0 to 0.5. Room temperature 57Fe Mössbauer spectra are recorded for these series. The hyperfine field value for octahedral and tetrahedral of samples increases from 484 and 390 kOe to 491 and 397 kOe respectability, as Bi replaces Y in (BixY3 − xFe5O12) atom with increasing x value. The effect of Bi3 +  substitution for Y3 +  on lattice constants, morphology and magnetic properties of pure YIG has been investigated

Sediment Loading and Water Quality of Field Run-off Water

Intensive tillage is commonly employed in many agronomic production systems in the United States. Tillage operations may include disking the field, re-smoothing the soil, seedbed formation, reducing the seedbeds, and shallow cultivation for weed control. Tillage practices in conjunction with rainfall have been linked to soil erosion, which may adversely affect the environment. The soil erosion dynamics of two large-scale production cotton fields that utilized both modern-conventional and conservation-tillage technology were examined. Studies were conducted in the cotton-producing region of southeast Arkansas in the Bayou Bartholomew watershed. Bayou Bartholomew is currently listed by the United States Environmental Protection Agency as an impacted stream. The soils at these sites were related, coarse-textured alfisols. One field was cropped to conventionally tilled cotton and intensively tilled. The second field was cropped to cotton using modern conservation tillage technology. Both fields were furrow-flow irrigated using piped water. Intense rainfall usually occurs in the Mississippi River Delta Region, particularly in the winter and spring months. Conservation tillage proved to be immediately beneficial in controlling soil erosion and sediment loss due to field run-off water from rainfall. Sediment content of run-off water induced by rainfall from the conventionally tilled cotton field was significantly greater than the sediments found in run-off water from the conservation tilled cotton field. The amount of sediment found in rainfall run-off water decreased more rapidly with time under conservation tillage than under conventional tillage. The tillage system made little difference in sediment content of run-off water from irrigation. The water flow from furrow irrigation is typically slow and steady. There is no droplet impact on the ground from furrow-flow irrigation as there would be from rainfall. Apparently, the gentle flow of the water down the furrows was insufficient to dislodge large numbers of soil particles

Generation and Propagation of Flexoelectricity-Induced Solitons in Nematic Liquid Crystals

Solitons in nematic liquid crystals facilitate the rapid transport and sensing in microfluidic systems. Little is known about the elementary conditions needed to create solitons in nematic materials. In this study, we apply a combination of theory, computational simulations, and experiments to examine the formation and propagation of solitary waves, or ”solitons”, in nematic liquid crystals under the influence of an alternating current (AC) electric field. We find that these solitary waves exhibit “butterfly”-like or “bullet”-like structures that travel in the direction perpendicular to the applied electric field. Such structures propagate over long distances without losing their initial shape. The theoretical framework adopted here helps identify several key factors leading to the formation of solitons in the absence of electrostatic interactions. These factors include surface irregularities, flexoelectric polarization, unequal elastic constants, and negative anisotropic dielectric permittivity. The results of simulations are shown to be in good agreement with our own experimental observations, serving to establish the validity of the theoretical concepts and ideas advanced in this work

Generation and propagation of solitary waves in nematic liquid crystals

Solitons in nematic liquid crystals offer intriguing opportunities for transport and sensing in microfluidic systems. Little is known about the elementary conditions that are needed to create solitons in nematic materials. In this work, theory, simulations and experiments are used to study the generation and propagation of solitary waves (or "solitons") in nematic liquid crystals upon the application of an alternating current (AC) electric field. We find that these solitary waves exhibit "butterfly"-like or "bullet"-like structures that travel in the direction perpendicular to the applied electric field. Such structures propagate over long distances without losing their initial shape. The theoretical model adopted here serves to identify some of the key requirements that are needed to generate solitons in the absence of electrostatic interactions. These include surface imperfections that introduce a twist in the director, unequal elastic constants, and negative anisotropic dielectric permittivity. The results of simulations are shown to be in good agreement with our own experimental observations, serving to establish the validity of the theoretical concepts advanced in this work

SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes

Splicing is catalyzed by the spliceosome, a compositionally dynamic complex assembled stepwise on pre-mRNA. We reveal links between splicing machinery components and the intrinsically disordered ciliopathy protein SANS. Pathogenic mutations in SANS/USH1G lead to Usher syndrome—the most common cause of deaf-blindness. Previously, SANS was shown to function only in the cytosol and primary cilia. Here, we have uncovered molecular links between SANS and pre-mRNA splicing catalyzed by the spliceosome in the nucleus. We show that SANS is found in Cajal bodies and nuclear speckles, where it interacts with components of spliceosomal sub-complexes such as SF3B1 and the large splicing cofactor SON but also with PRPFs and snRNAs related to the tri-snRNP complex. SANS is required for the transfer of tri-snRNPs between Cajal bodies and nuclear speckles for spliceosome assembly and may also participate in snRNP recycling back to Cajal bodies. SANS depletion alters the kinetics of spliceosome assembly, leading to accumulation of complex A. SANS deficiency and USH1G pathogenic mutations affects splicing of genes related to cell proliferation and human Usher syndrome. Thus, we provide the first evidence that splicing dysregulation may participate in the pathophysiology of Usher syndrome

A new measure of patient satisfaction with ocular hypotensive medications: The Treatment Satisfaction Survey for Intraocular Pressure (TSS-IOP)

PURPOSE: To validate the treatment-specific Treatment Satisfaction Survey for Intraocular Pressure (TSS-IOP). METHODS: Item content was developed by 4 heterogeneous patient focus groups (n = 32). Instrument validation involved 250 patients on ocular hypotensive medications recruited from ophthalmology practices in the Southern USA. Participants responded to demographic and test questions during a clinic visit. Standard psychometric analyses were performed on the resulting data. SAMPLE: Of the 412 patients screened, 253 consented to participate, and 250 provided complete datasets. The sample included 44% male (n = 109), 44% Black (n = 109) and 57% brown eyed (n = 142) participants, with a mean age of 64.6 years (SD 13.1) and a history of elevated IOP for an average of 8.4 yrs (SD 7.8). A majority was receiving monotherapy (60%, n = 151). RESULTS: A PC Factor analysis (w/ varimax rotation) of the 31 items yielded 5 factors (Eigenvalues > 1.0) explaining 70% of the total variance. Weaker and conceptually redundant items were removed and the remaining 15 items reanalyzed. The satisfaction factors were; Eye Irritation (EI; 4 items), Convenience of Use (CofU; 3 items), Ease of Use (EofU; 3 items), Hyperemia (HYP; 3 items), and Medication Effectiveness (EFF; 2 items). Chronbach's Alphas ranged from .80 to .86. Greater distributional skew was found for less common experiences (i.e., HYP & EI with 65% & 48.4% ceilings) than for more common experiences (i.e., EofU, CofU, EFF with 10.8%, 20.8% & 15.9% ceilings). TSS-IOP scales converged with conceptually related scales on a previously validated measure of treatment satisfaction, the TSQM (r = .36 to .77). Evidence of concurrent criterion-related validity was found. Patients' symptomatic ratings of eye irritation, hyperemia and difficulties using the medication correlated with satisfaction on these dimensions (r = .30-.56, all p < .001). Clinicians' ratings of IOP control, severity of side effects and problematic medication use correlated with patients' satisfaction scores on these dimensions (r = .13-.26, all p < .01). CONCLUSIONS: This study provides initial evidence that the TSS-IOP is a reliable and valid measure, assessing patients' satisfaction with ocular hypotensive medications