1 research outputs found
Physicochemical code for quinary protein interactions in Escherichia coli
This study shows that the diffusive motions of proteins in live cells are by no means without control but follow simplistic physicalâchemical rules that can be quantified and optimized through surface composition. Most strikingly, human proteins are observed to stick to the âforeignâ environment of bacterial cells, whereas the bacterial analogue moves around freely. Even so, the human proteins can predictably be transformed to bacterial behavior with a few structurally benign surface mutations, and, conversely, the bacterial protein can be made to stick. The findings have not only fundamental implications for how protein function is controlled at the physicalâchemical level but can also be used to adjust protein motion in Escherichia coli at will