Association between the digit ratio (2D:4D) and body fat distribution in Mordovian students

Background: The length ratio of the second to the fourth finger (2D:4D) is a possible biomarker of prenatal sex hormone levels, which play a significant role in determining sex-related body traits. Aims: To evaluate the value of the 2D:4D ratio in a Mordovian sample and to test the associations between the 2D:4D ratio and sexually dimorphic morphological traits, such as height and body weight, body mass index, waist and hip circumference, the waist-to-hip ratio, handgrip strength and the skinfold thickness. Subjects and methods: The sample studied included 106 individuals of Mordovian ethnicity: 58 males and 48 females, 16–23 years old. The associations between the 2D:4D ratio and morphological traits were evaluated by multivariate regression analysis and correlation analysis. Results: The 2D:4D ratio in males was significantly lower than in females. Most of the associations of the 2D:4D ratio with morphological traits were statistically insignificant. The 2D:4D ratio is only significantly correlated with skinfold thickness of the forearm and the abdomen in females. Conclusion: The association between the 2D:4D ratio and skinfold thickness is indicative of the role of prenatal sex hormones in shaping the body fat distribution in females, along with the significant impact of sex hormones at puberty

Visual outcomes of small-incision lenticule extraction (SMILE) in thin corneas

We aimed to find out whether thin (≤500 μm) or normal (>500 μm, control) corneal thickness would impact efficacy and safety outcomes of small-incision lenticule extraction (SMILE). We retrospectively analyzed medical records of adult patients who had undergone SMILE. A total of 57 eyes were included in the "thin corneas" group and 180 eyes in the "control" group. At one month after surgery, rates of patients with uncorrected distance visual activity (UDVA) ≥ 0.8 were significantly higher in patients from the control group compared to the "thin corneas" group (87 vs. 71%, respectively p < 0.01), though rates were comparable at 3 months (87 vs. 76%, respectively, p > 0.05). SMILE had comparable safety in patients with thin and normal corneas. Procedure result predictability was comparable between groups. Regression analysis demonstrated that cap thickness impacted posterior corneal biomechanics, and the volume of removed tissue had a higher influence in patients with thin corneas. Moreover, an increase in cap thickness was associated with better final BCVA. Further study is needed for the evaluation of the impact of thin corneas on SMILE outcomes and planning. Our study also indicates that patients with thin corneas might require a different approach to nomogram calculation

Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte

Mammalian oocytes are arrested in meiotic prophase by an inhibitory signal from the surrounding somatic cells in the ovarian follicle. In response to luteinizing hormone (LH), which binds to receptors on the somatic cells, the oocyte proceeds to second metaphase, where it can be fertilized. Here we investigate how the somatic cells regulate the prophase-to-metaphase transition in the oocyte, and show that the inhibitory signal from the somatic cells is cGMP. Using FRET-based cyclic nucleotide sensors in follicle-enclosed mouse oocytes, we find that cGMP passes through gap junctions into the oocyte, where it inhibits the hydrolysis of cAMP by the phosphodiesterase PDE3A. This inhibition maintains a high concentration of cAMP and thus blocks meiotic progression. LH reverses the inhibitory signal by lowering cGMP levels in the somatic cells (from ∼2 μM to ∼80 nM at 1 hour after LH stimulation) and by closing gap junctions between the somatic cells. The resulting decrease in oocyte cGMP (from ∼1 μM to ∼40 nM) relieves the inhibition of PDE3A, increasing its activity by ∼5-fold. This causes a decrease in oocyte cAMP (from ∼700 nM to ∼140 nM), leading to the resumption of meiosis