PPh3-Catalyzed Intramolecular Cyclization of hydroxypropargylamides: Synthesis of Structurally Diverse Morpholinone Derivatives

The metal-free synthesis of functionalized morpholinones through a sequential intramolecular post-ugi cyclization strategy is described. In the subsequent step, Ugi adducts hydroxypropargylamides derivative undergoes chemo- and regioselective 6-exo-dig catalytic cyclization to afford O-cyclized product in the presence of triphenylphosphine. This sequence offers an engrossing functionalized morpholinones scaffolds involving moderate reaction conditions with broad substrate scopes and moderate to good yields

PPh3-catalyzed intramolecular cyclization of hydroxypropargylamides: Synthesis of structurally diverse morpholinone derivatives

1014-1024The metal-free synthesis of substituted morpholinones through a sequential intramolecular post-Ugi cyclization strategy is described. In the subsequent step, Ugi adducts hydroxy propargylamides derivatives undergo chemo- and regioselective 6-exo-dig catalytic cyclization to afford O-cyclized products in the presence of triphenylphosphine. This sequence offers an engrossing functionalized morpholinone scaffold involving moderate reaction conditions with broad substrate scope and moderate to good yields