29 research outputs found
Multiple sclerosis and certain neurodegenerative diseases are caused by high energy electromagnetic fields (EMF) like geomagnetic storms. : A hypothesis.
The expression of PI3K/Akt/mTOR signaling pathway in early-stage small cell carcinoma of the uterine cervix
Prevention of apoptosis by neurotrophic factors -Contribution of pathophysilogical analysis to therapy of neurodegenerative diseases-
Down-Regulation of miR-92 in Human Plasma Is a Novel Marker for Acute Leukemia Patients
BACKGROUND: MicroRNAs are a family of 19- to 25-nucleotides noncoding small RNAs that primarily function as gene regulators. Aberrant microRNA expression has been described for several human malignancies, and this new class of small regulatory RNAs has both oncogenic and tumor suppressor functions. Despite this knowledge, there is little information regarding microRNAs in plasma especially because microRNAs in plasma, if exist, were thought to be digested by RNase. Recent studies, however, have revealed that microRNAs exist and escape digestion in plasma. METHODOLOGY/PRINCIPAL FINDINGS: We performed microRNA microaray to obtain insight into microRNA deregulation in the plasma of a leukemia patient. We have revealed that microRNA-638 (miR-638) is stably present in human plasmas, and microRNA-92a (miR-92a) dramatically decreased in the plasmas of acute leukemia patients. Especially, the ratio of miR-92a/miR-638 in plasma was very useful for distinguishing leukemia patients from healthy body. CONCLUSIONS/SIGNIFICANCE: The ratio of miR-92a/miR-638 in plasma has strong potential for clinical application as a novel biomarker for detection of leukemia
Immunoreactive Myelin Basic Protein in Tumor Cells Associated with Carcinomatous Neuropathy
Multiple sclerosis and certain neurodegenerative diseases are caused by high energy electromagnetic fields (EMF) like geomagnetic storms. : A hypothesis.
Cystic Dysplastic Kidneys Associated with Dandy-Walker Malformation and Congenital Hepatic Fibrosis: Report of Two Cases
Characteristics of histopathological and ultrastructural features of placental villi in pregnant Nepalese women
Whole-Blood Counting Immunoassay as a Short-Turnaround Test for Detection of Hepatitis B Surface Antigen, Anti-Hepatitis C Virus Antibodies, and Anti-Treponema pallidum Antibodies
Whole-blood samples were used for a counting immunoassay (CIA) with the aim of developing a short- turnaround test. After optimization of the CIA, hepatitis B surface antigen (HBsAg), anti-hepatitis C virus antibodies (anti-HCV), and anti-Treponema pallidum antibodies (anti-TP) were detected as efficiently as by an enzyme immunoassay (EIA) with serum samples. The correlations between whole-blood CIA and serum EIA were 99.8, 97.1, and 99.4% for HBsAg, anti-HCV, and anti-TP, respectively. Whole-blood CIA may be of value when rapid screening of many samples is required