Intraoperative Heparin Injection Reduced D-dimer and TAT Levels after Total Hip Arthroplasty

Recently, the incidences of pulmonary embolism (PE) and/or deep vein thrombosis (DVT) after orthopedic operation increased in Japan. However the effective prevention methods have not been established yet. To make the effective prevention of PE and/or DVT after total hip arthroplasty (THA), we investigated the time-dependent changes of serum thrombin-antithrombin III complex (TAT) and D-dimer levels after THA. We measured changes of serum TAT, and D-dimer levels (before, on day 1, day 5, week 2 and week 4 after operation). Twenty-six women (mean age 64.5 years old), who had undergone THA for osteoarthritis of the hip joint were enrolled and divided into two groups at random. One group had been intravenously injected with 1,000 units of heparin during THA (IH Group, 14 patients), and the other group had not been injected (NH Group, 12 patients). No patients showed clinical PE and/or, DVT. The levels of TAT and D-dimer in IH group significantly reduced compared with these in NH group on the fifth and first postoperative day, respectively (p Our data suggests that intravenous heparin injection during THA might be a potentially effective and safe strategy for prophylaxis of PE after THA

The effect of pCO2 on size-fractionated phytoplankton community in the Southern Ocean

第3回極域科学シンポジウム　横断セッション「南極海季節的海氷域における生物地球化学」11月26日（月） 統計数理研究所 セミナー

Variability in Xanthophyll Pigments and Maximum Quantum Yield (Fv/Fm) of Ice Algae in Saroma-Ko Lagoon, Hokkaido

第2回極域科学シンポジウム/第33回極域生物シンポジウム 11月17日（木） 統計数理研究所 3階リフレッシュフロ

Serum amyloid A-induced IL-6 production by rheumatoid synoviocytes

AbstractIn this study, we investigated the role of serum amyloid A protein (SAA) in the production of interleukin-6 (IL-6) using rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). Recombinant SAA stimulation induced the production of pro-inflammatory cytokine, IL-6, from RA-FLS. The signaling events induced by SAA included the activation of the mitogen-activated protein kineases, p38 and JNK1/2 and the activation of nuclear factor-kappa B (NF-κB). Inhibitor studies have shown SAA-induced IL-6 production to be down-regulated by NF-κB inhibition and partially inhibited by p38 or JNK inhibitors. Our findings demonstrate that SAA is a significant inducer of IL-6, which is critically involved in RA pathogenesis

Photoprotection and xanthophyll cycle activity of ice algae in Saroma-Ko Lagoon, Hokkaido, Japan

第3回極域科学シンポジウム/第34回極域生物シンポジウム 11月26日（月） 統計数理研究所 ３階セミナー

Spatial Variability in Biomass and Photosynthetic Characteristics of Bottom Ice Algae in Saroma-Ko Lagoon, Hokkaido

第3回極域科学シンポジウム/第34回極域生物シンポジウム 11月26日（月） 国立極地研究所 ３階ラウン

ランダム化比較試験によるエドキサバン投与下におけるTKA後DVT発生に対するフットポンプの有効性

長崎大学学位論文 [学位記番号]博（医歯薬）甲第986号 [学位授与年月日]平成29年9月20

Size-dependent absorption property of phytoplantkon in the Southern Ocean

第2回極域科学シンポジウム　共通セッション「海氷圏の生物地球化学」 11月16日（水） 統計数理研究所 3階セミナー

Photophysiological characteristics of ice algal community in Saroma-ko Lagoon, Hokkaido ~Weak photoacclimation of ice algal community in 2009~

第3回極域科学シンポジウム/第34回極域生物シンポジウム 11月26日（月） 国立極地研究所 ３階ラウン