Combined Branch Retinal Vein and Artery Occlusion in Toxoplasmosis with Hyperhomocysteinemia, and Mutation of Factor V Leiden

Moreover, heterozygosity of a mutation of factor V Leiden; FVL (coagulation factor V gene) was also observed in the case. The patient was diagnosed with branch retinal vein and artery occlusion with hyperhomocysteinemia and mutation of factor V Leiden. The patient was underwent intravitreal injection of bevacizum (IVB), and PRP laser due to severe retinal ischemia and extensive NVD. The patient was treated with sulfamethoxazole (800 mg), trimethoprim (160 mg), and corticosteroid (1-1.5 mg/kg/day). Vitamin B6 (100 mg/daily), acid folic (5 mg daily), and vitamin B12 (112 mg/daily) were also added to the treatment for 8 weeks. After treatment, the assessment of plasma homocysteine showed that the level of homocysteine was normal. This is the first report of combined retinal branch vein and artery occlusion in toxoplasmosis with hyperhomocysteinemia and mutation of factor V Leiden