The effect of low omega-3/omega-6 ratio on auditory nerve conduction in rat pups

The biological effects of omega-3 and omega-6 fatty acids are determined by their mutual interactions. This interaction extremely affects various functions. Lower consumption of omega-3 during gestation leads to various disorders, even in hearing. We aimed to assess the effect of low omega-3/omega-6 ratios on auditory nerve conduction. In this experimental study, the auditory brainstem response test was performed on a 24-day-old rat (n=14). The rats were divided into case (low omega-3/omega-6 ratio during gestation and lactation) and control groups. Variables such as P1, P3, and P4 absolute latency period, interpeak (P3-P4, P1-P3 and P1-P4), and P4/P1 amplitude ratio were measured. We found an increased P4 omega-3/omega-6 ratio in the group with a low omega-3/omega-6 ratio (P0.05). Also, no significant difference was observed between the groups with respect to the P1-P3 interpeak latency (IPL) periods (P>0.05); while the P1-P4 and P3-P4 IPLs were significantly increased in the group with a low omega-3/omega-6 ratio (P<0.05). The P4/P1 amplitude ratio significantly decreased in the group with a low omega-3/omega-6 ratio (P<0.05). Results confirmed the negative effects of low omega-3/omega-6 ratio on the auditory system and hearing. © 2015 Tehran University of Medical Sciences. All rights reserved

Prevalence Of Dangerous Complications Of Chronic Otits Media After Operation 1991 - 98

Chronic otitis media and mastoiditis is a common otologic condition. Although it does not occur as frequently as acute otitis media, but remains a persistent and perplexing problem. Nowadays, although with improved access to medical care , advanced technology of imaging and entrance of new powerful antimicrobials, dangerous and deathful complications of c.o.m have become less common significantly, but unfortunately more of less serious complications is seen continuously.&quot;nMaterials and Methods: A retrospective study of 1500 patients with C.O.M that had been operated during the years 1991 - 97 in Amir hospital was conducted.&quot;nResults: patients had ages between 8 months to 78 years old with a peak incidence at 3rd decade of life. Among that patients, 56 patients (3.7 percent) had one of major C.O.M complications. Over ally, in order of frequency, we found: facial nerve paralysis 27 pt (1.8 percent) labyrinthitis and perilymphatic fistula 16 pt (1.06 percent) Intracranial abscess 5 pt (0.33 percent), lateral sinus thrombosis 4 pt (0.26 percent) Meningitis 2 pt (0.13 percent) and Bezold&apos;s abscess 2 pt (0.13 percent) peak - age incidence of complications was 3rd decade of life and M/F incidence of complications was 3/2.&quot;nConclusion: The early diagnosis and treatment of C.O.M complications are very important (specially intracranial complications), but it can be possible if the physician thinks about it

Clinical and laboratory evaluation of thyroid function following total laryngectomy in laryngeal cancer

Background: Hypothyroidism is a well-documented complication after treatment of laryngeal cancer and is particularly significant among patients undergoing laryngectomy. We investigated the frequency of hypothyroidism in patients treated with total laryngectomy for laryngeal cancer. We also evaluated the effect of neck radiotherapy on thyroid function after total laryngectomy for laryngeal cancer. Methods: In a cross-sectional study, we evaluated 31 patients with laryngeal squamous cell carcinoma (mean age 53.6 years). Among these patients, 14 were treated with surgery only and 17 were treated with surgery plus radiotherapy. Laboratory evaluation included levels of thyroid stimulating hormone (TSH), free T4, free T3, and antithyroid antibodies both preoperatively and postoperatively at the first day, as well as one and six months after surgery. Results: All patients had normal thyroid function before treatment; however, after 6 months, five patients (16.1%) were hypothyroid. Of these, three patients (9.6%) had subclinical symptoms, including elevated thyroid-stimulating hormone with normal free T4, and two patients (6.5%) showed clinical symptoms of hypothyroidism. Radiotherapy and neck dissection were significantly associated with higher incidences of hypothyroidism. Conclusion: Our data suggest that hypothyroidism occurs in a substantial proportion of patients undergoing surgery for laryngeal cancer. The results indicate that thyroid function studies should be routinely performed in the follow-up care of laryngeal cancer patients, especially if radiotherapy and neck dissection were part of the treatment. We suggest that this approach will improve the patient&apos;s quality of life and diminish the co-morbidity associated with this kind of surgery

Audiometric changes after coronary artery bypass graft

Background: Hearing is one of the most significant senses; There fore, any defect can be frightening. The incidence of sever hearing loss following coronary artery bypass surgery has been estimated as one per thousand. This Prospective study carried out to determine hearing effects of coronary artery bypass surgery.&quot;nMethods: age, audiometric changes before and after surgery (hearing levels at multiple frequencies, speech reception threshold and speech discrimination score), minimum blood pressure during the operation, and the time on bypass, measured on One hundred consecutive patients who candidate for coronary artery bypass surgery and the results analysed.&quot;nResults: One hundred patients completed the tests. Based on hearing changes found on pre- and post-operative tests, the patients were divided into 3 groups: Those with no change (47 patients) according to their audiometric results; those with slight changes &amp;le;10 db (43 patients); and those having average deficits of more than 10 db (10 patients). All the patients were male. None of the patients had complete or severe sensorineural hearing loss. The third group had more prolonged pumping duration when compared with the others groups (p=0.002). Furthermore, 90 percent of patients with a sensorineural hearing loss more than 10 db had diabetes mellitus and hyperlipidemia as risk factors.&quot;nConclusion: Sudden sensorineural hearing loss is a sequela in patients who undergoing coronary artery bypass surgery; however, it was usually mild and asymptomatic. Pumping time during the operation is a significant factor in occurring of this complication. With proper treatment of underlying diseases and eliminating the risk factors with improvement of our cardiopulmonary pumps we probably can get better hearing results