Diversity and Specialization in Collaborative Swarm Systems

This paper addresses qualitative and quantitative diversity and specialization issues in the frame- work of self-organizing, distributed, artificial systems. Both diversity and specialization are obtained via distributed learning from initially homogeneous swarms. While measuring diversity essentially quantifies differences among the individuals, assessing the degree of specialization implies to correlate the swarm’s heterogeneity with its overall performance. Starting from a stick-pulling experiment in collective robotics, a task that requires the collaboration of two robots, we abstract and generalize in simulation the task constraints to k robots collaborating sequentially or in parallel. We investi- gate quantitatively the influence of task constraints and type of reinforcement signals on diversity and specialization in these collaborative experiments. Results show that, though diversity is not explicitly rewarded in our learning algorithm and there is no explicit communication among agents, the swarm becomes specialized after learning. The degree of specialization is affected strongly by environmental conditions and task constraints, and reveals characteristics related to performance and learning in a more consistent and clearer way than diversity does

The possible link between the elevated serum levels of neurokinin A and anti-ribosomal P protein antibodies in children with autism

<p>Abstract</p> <p>Background</p> <p>Neurogenic inflammation is orchestrated by a large number of neuropeptides. Tachykinins (substance P, neurokinin A and neurokinin B) are pro-inflammatory neuropeptides that may play an important role in some autoimmune neuroinflammatory diseases. Autoimmunity may have a role in the pathogenesis of autism in some patients. We are the first to measure serum neurokinin A levels in autistic children. The relationship between serum levels of neurokinin A and anti-ribosomal P protein antibodies was also studied.</p> <p>Methods</p> <p>Serum neurokinin A and anti-ribosomal P protein antibodies were measured in 70 autistic children in comparison to 48 healthy-matched children.</p> <p>Results</p> <p>Autistic children had significantly higher serum neurokinin A levels than healthy controls (P < 0.001). Children with severe autism had significantly higher serum neurokinin A levels than patients with mild to moderate autism (P < 0.001). Increased serum levels of neurokinin A and anti-ribosomal P protein antibodies were found in 57.1% and 44.3%, respectively of autistic children. There was significant positive correlations between serum levels of neurokinin A and anti-ribosomal P protein antibodies (P = 0.004).</p> <p>Conclusions</p> <p>Serum neurokinin A levels were elevated in some autistic children and they were significantly correlated to the severity of autism and to serum levels of anti-ribosomal P protein antibodies. However, this is an initial report that warrants further research to determine the pathogenic role of neurokinin A and its possible link to autoimmunity in autism. The therapeutic role of tachykinin receptor antagonists, a potential new class of anti-inflammatory medications, should also be studied in autism.</p

Alpha self-absorption evaluation in radiometric filter material for the natural range of alpha energy (5-9 MeV)

In this paper, SRIM (The Stopping and Range of Ions in Matter) software package is used to simulate the interaction of alpha particles into the material of radiometric analytical filters. The effect of alpha particle self-absorption in alpha radiometric filters measurements is estimated, especially in the range of natural alpha energy (5-9 MeV, Radon and Thoron alpha energy). Software package SRIM allows to calculate the parameters of the ions interaction with target material using a Monte Carlo simulation method based on a quantum mechanical treatment of ion-atom collisions. The effect of the radiometric analytical filter material on the transmitted efficiency of alpha energy is discussed. As the energy increases the self-absorption in analytical filter material is decreased but still has a clear effect. In this case, the filter material and the space distance between the filter and the detector window decrease the number of alpha particles which reach to the detector window. © 2019 RAD Association. All rights reserved

Radiopharmaceutical dose distribution in different organs and tissues for Lu-177 with different carrier

177Lu refers to rare earth elements from a group of lanthanides. Relative to its short time span, 177Lu has virtually pervaded all areas of in vivo radionuclide therapy and becomes one of important keys for therapeutic radionuclides of choice for targeted radionuclide therapy. The rising interest in the use of 177Lu in targeted molecular therapies has primarily developed from recent unmatched advances in molecular and cell biology, which include the use of peptides targeted to cell surface receptors, which are overexpressed on the surface of tumour cells. Therefore, the use of 177Lu-labelled radiopharmaceuticals have been the major factors evoking excitement among researchers and capturing the imagination of the clinical community thanks to advances in molecular and cellular biology. In this work, radiopharmaceutical comparison for 177Lu absorbed dose in health human organs and tissues is presented. The comparison between unlabelled 177Lu (ionic form) and labelled with 177Lu-MDP (methylenediphosphonate) and 177Lu-MAb (monoclonal antibodies). The biokinetic model in each case are described and presented. The absorbed dose in health human organs and tissues are simulated with two recommended programs WinAct and IDAC 2.1(Internal Dose Assessment by Computer) software. The distribution of absorbed dose in the main organs nearly the same with different in the value for the ionic form and 177Lu-MDP. The absorption in the case of ionic form is high. The distribution is completely change while 177Lu-MAb is used. The most absorbed dose fraction goes to spleen and liver unlike bone surface absorb nearly 50 % of dose. © 2019 Author(s)

Water Absorption Enhancement Of Sodium Poly Acrylate And Poly(2-Acrylamido-2-Methylpropane Sulphonic Acid) Based Hydrogel Mixtures

Introduction: Hydrogels are hydrophilic polymers which are cross-linked to form three-dimensional structures, which can absorb, swell and retain huge amounts of water or aqueous fluids. Objective: This paper reports the preparation and characterization of Poly (2-Acrylamido-2-Methylpropane Sulphonic Acid) (PAMPS) hydrogel with different crosslinking intensities. Methodology: 2-Acrylamido-2-methylpropane sulfonic acid (AMPS) monomer was purchased from Alfa Aesar Company as reagent grade. It was used as received (\u3e98% purity) without any further purification. PAMPS hydrogel was prepared by free radical crosslinking solution polymerization of AMPS in water at room temperature under a nitrogen blanket in cylindrical glass tubes. The characteristics of the obtained PAMPS hydrogel were compared with those of commercial sodium polyacrylates hydrogel. Results: It was found that decreasing the crosslinker weight improved the absorbance capacity but to a limit. The suggested reasons were discussed. The mixture showed higher absorbance rate than PAMPS, and bigger absorbance capacity than sodium polyacrylates. Conclusion: This paper investigates the effect of crosslinker ratio on the swelling capacity of PAMPS. It was found that as the crosslinking ratio decreases, the porosity of the hydrogel increases, thus improving the swelling capacity