Information Technology (IT) and Teaching Method: An Assessment on the Students of Social Science Faculty and Business Faculty of University of Dhaka

Bangladesh is a developing country where Information Technology (IT) is ever not highly developed but Government has a dream to develop this sector so that IT can entrance in every sector in Country. Information technology (IT) is an umbrella term, the use of computers and telecommunications equipment to store, retrieve, transmit and manipulate data. It is now a part of nearly every aspect of daily life in developing country- Bangladesh and is the backbone of many successful initiatives such as improving teaching quality of education. Information technologies are assumed to play a constructive role in education to make the teaching and learning process more productive through collaboration in an information rich society. Information rich society promotes new practices and paradigms for education where the teacher has to play new role of mentoring, coaching and helping students in their studies rather to play the conventional role of spoon-feeding in the classrooms. Students can learn independently having a wide choice of program selection and access to information. Information technology complements and enhances traditional teaching system through emphasis on the information basis in University of Dhaka. This study attempts to explore the impacts of information technology on teaching as well as learning system of educational institutions. In this research report, mixed method (both qualitative and quantitative method) is used to get an insight view about the related issues. It is observed that IT based learning system is a modern method of teaching and learning process which is helpful both for teachers and students. Keywords: Education, Information Technology, Teaching, Teaching method, Learning process

Simultaneous quantitative analysis of tamsulosin and finasteride in pharmaceutical dosage form by U-HPLC Tandem mass spectrometry

A sensitive, rapid, selective and accurate liquid chromatography coupled to quadrupole tandem mass spectrometry (LC-MS/MS) method was developed for simultaneous identification and quantification of tamsulosin and finasteride in bulk and in their combined dosage form. Chromatography was performed on a Hypersil gold 50 mm × 2 mm (1.9 μm) column, using acetonitrile:ammonium acetate (90:10, v:v) pH = 3.5 as the mobile phase. Protonated ions formed by a turbo ion-spray in positive mode were used to detect the analytes as well as the internal standard (IS). MS/MS detection was carried out by monitoring the fragmentation of 408.74 → 227.29 (m/z), 373.11 → 304.96 (m/z) and 255.75 → 166.15 (m/z) for tamsulosin, finasteride and diphenhydramine (IS), respectively, on a triple quadrupole mass spectrometer. The linearity was obtained over the concentration range of 1.6-40.0 ng/mL for tamsulosin and 20.0-500.0 ng/mL for finasteride with a lower limit of detection of 0.5 ng/mL and 5.0 ng/mL for the two drugs, respectively. The proposed method was successfully applied to tamsulosin and finasteride determination in pharmaceutical dosage form. The results obtained were statistically analyzed and compared with those of reference ones; in addition, the method was validated according to USP 34 recommendations. The simplicity and sensitivity of this method allows its use in the quality control of the cited drugs and can be extended for routine analysis of the drugs in their pharmaceutical preparations

Disruption of Individual Mobility Ahead? A Longitudinal Study of Risk and Benefit Perceptions of Self-Driving Cars on Twitter

In this paper, we address the question if there is a disruption of individual mobility by self-driving cars ahead. In order to answer this question, we take the user perspective and conduct a longitudinal study of social media data about self-driving cars from Twitter. The study analyzes 601,778 tweets from March 2015 to July 2016. We use supervised machine learning classification to extract relevant information from this huge amount of unstructured text. Based on the classification, we analyze how risk and benefit perceptions of self-driving cars develop over time, and how they are influenced by certain events. Based on the perceived risks and benefits, we draw conclusions for the acceptance of self-driving cars. Our study shows that a disruptive innovation of self-driving cars is not likely as risk and benefit perception issues indicate a lack of acceptance. We provide suggestions for improving the acceptance of self-driving cars

Dendrogram Analysis and Statistical Examination for Total Microbiological Mesophilic Aerobic Count of Municipal Water Distribution Network System

The microbiological quality of water for human consumption is a critical safety aspect that should not be overlooked, especially when considering facilities for healthcare and the treatment of ill populations. Thus, the biological stability of water is crucial for the distribution network that delivers potable water to the final users for consumption and other human activities. The present work aimed to study a municipal distribution network system for city water within a healthcare facility. The implementation of the statistical analysis was conducted over long-term data collection, and the comparative study for the microbiological count of the water samples - from different points-of-use was assessed using the non-parametric analysis of the Kruskal-Wallis test. The comparative study involved a preliminary general one-way Analysis of Variance (ANOVA) followed by ad-hoc pairwise comparison. The statistical study involved a correlation matrix and a dendrogram to elucidate the level of association between different sections in the network. The ports C4 and C13 were at the trough in the microbiological count, in contrast to C13, which showed the highest level of the average microbial density. Despite a low to moderate level of correlation between the datasets of the water network, the tree diagram (dendrogram) analysis showed remarkable clustering. Use points could be grouped into three dense groups based on abrupt cuts in the similarity value. The study was useful in the analysis of the pattern and behavior of the microbial quality in a distribution water network in a specific area of the study. This work in turn would help in investigating the areas of improvement and defect spotting, in addition to assessing the biological stability of the water distribution system. The study could be extended to cover other different processed water networks, such as distilled, deionized, and purified water, as well as Water-For-Injection (WFI). Doi: 10.28991/HIJ-2022-03-01-03 Full Text: PD

Microbiological Antibiotic Assay Validation of Gentamicin Sulfate Using Two-Dose Parallel Line Model (PLM)

Nowadays, microbiological assay is still widely used with several antibiotics that are composed of a mixture of related active compounds. However, obtaining a reasonably valid determination of the potency is dependent on the validity and suitability of the assay design. The present work aimed to validate an assay design for an aminoglycoside antibiotic (Gentamicin Sulfate) using a two-dose Parallel Line Model agar diffusion assay in a large 8×8 rectangular plate. All preparatory procedures were done following the United States Pharmacopeia and the inhibition zones were measured using a digital caliper to the nearest 0.01 mm. Analysis of variance in compendial requirements for regression and parallelism were found to satisfactorily meet the acceptance criteria. Specificity was achieved for the product under investigation with no detectable IZ that could be found for all components except the antibiotic. The validation method showed an acceptable linearity of r2≥0.98. Accuracy and precision parameters showed RSD (%)<2. All relative error value estimates were below 4%. The proposed validation design for 32×32 cm antibiotic plates yielded valid results and can be projected for the routine Quality Control analysis of the antibiotic material, especially that which is incorporated into a finished medicinal dosage form. Doi: 10.28991/HIJ-2021-02-04-04 Full Text: PD

Quality of life among parents of children with heart disease

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

ZOLMITRIPTAN BRAIN TARGETING VIA INTRANASAL ROUTE USING SOLID LIPID NANOPARTICLES FOR MIGRAINE THERAPY: FORMULATION, CHARACTERIZATION, IN-VITRO AND IN-VIVO ASSESSMENT

Objective: Zolmitriptan, a class of antidepressant drugs with poor bioavailability due to its first-pass metabolism. The aim of this study was to improve systemic bioavailability and explore the brain targeting impact of nasal Zolmitriptan (Zol) solid lipid nanoparticles (SLNs) gel for migraine treatment.&nbsp; Methods: Stearic acid and cholesterol used as solid lipid and lecithin as a surfactant, emulsion solvent evaporation technique was used to produce Zolmitriptan SLNs. (Zol) SLNs were characterized for particle size, percent entrapment efficiency and&nbsp;in vitro&nbsp;drug release. Formula S6 showed greater percent entrapment efficiency (PEE), adequate particle size and sustained drug release behavior. Formula S6 was integrated into HPMC gel (3%) to prepare nasal gel. Zol SLN nasal gel was subjected to histopathological study to ensure brain targeting.&nbsp; Results: It was observed that all prepared Zol SLNs were in the nano-sized range with a polydispersity index of&lt;0.5. In the cholesterol/lecithin combination, higher PEE%, better stability, and less agglomeration inclination were discovered. Results of the release profiles showed that developed Zol-SLNs were able to release Zolmitriptan in a sustained manner. Histopathological study of the brain tissues showed that Zolmitriptan SLN nasal gel can reach brain cells and localized for 24 h although the hydrophobicity of the target drug. Conclusion: Intranasal administration of Solid lipid nanostructure of Zolmitriptan through the olfactory pathway in which it travels from the nasal cavity to brain tissue achieved drug targeting potential of about 90% compared with conventional Zolmitriptan tablets. The small particle size helped them to squeeze themselves through the small opening in the olfactory neurons to the brain via different endo-cystic pathways of neuronal cells in nasal tissue membranes

Low cost detection of hepatitis C virus RNA in HCV infected patients by SYBR Green I real-time PCR

The prevalence of hepatitis C virus (HCV) is highest in Egypt compared to other countries. Nucleic acid amplification test (NAT) allows detection of HCV early during the course of infection. Unfortunately, NAT is more expensive than ELISA, thus its routine use as a screening tool for blood products or in clinical practice is quite limited. The aim of this study was to compare two common RT-PCR methods, TaqMan probe technique and SYBR Green method in quantitative detection of HCV RNA for diagnosis and follow up of HCV patients. Among the recruited 220 HCV patients, 154 (70%) were HCV-RNA positive by both the techniques, while 24 (10.9%) were negative by both techniques. On the other hand, 40 (18.2%) cases were HCV RNA positive only by SYBR Green technique, and 2 (0.9%) only by TaqMan probe technique. Forty (20.4%) of the 196 chronic HCV cases were HCV-RNA positive by SYBR Green but negative by TaqMan probe technique.Conclusion: This method is useful for rapid qualitative detection of HCV infection and particularly suitable for routine diagnostic applications.Keywords: HCV, PCR, SYBR Green 1, TaqMan probe, Viral loa

TRA-941: EFFECTIVENESS OF VARIABLE MESSAGE SIGNS IN IMPROVING THE ROAD NETWORK THROUGH ROUTE GUIDANCE

Variable Message Signs (VMS) are a means of providing valuable information to roadway users and enhancing the performance of the road network. The main objective of this research was to analyze the effectiveness of the use of VMS in improving the efficiency of the road network. This was implemented through a number of case studies under different conditions and different designs of the VMS. As this is a unique traffic guidance method to Egypt, the different factors that may affect the effectiveness of the sign to divert drivers was studied to fully understand the benefits of implementing VMS in Egypt. Traffic data was collected from five sites which are located in Giza Governorate, Egypt. At each location, the driver had the choice of two alternative routes leading to the same destination. The VMS informed the drivers that one of these routes was congested and to use an alternative route. Three different sign types were applied to identify the most effective type of VMS on drivers in Egypt. The most effective sign type was identified during the pilot study and used in the remaining sites. For each site, Traffic counts for each route was recorded for twenty minutes without the VMS and twenty minutes with the VMS applied to obtain the diversion rate of drivers Average travel times for 30 vehicles and queue lengths were also recorded before and after the application of the VMS and Queue lengths were also recorded before and after applying the VMS

Histological study on the protective effect of endogenous stem-cell mobilization in Adriamycin-induced chronic nephropathy in rats

AbstractChronic kidney disease is a global health problem with increasing morbidity and mortality. Therefore, this study was planned to test the protective effect of hematopoietic-stem-cell mobilization by granulocyte colony-stimulating factor (G-CSF) on Adriamycin (ADR)-induced chronic renal disease in rats. Thirty albino rats were equally divided into three groups: control, ADR group [rats received a single intravenous injection of ADR (5mg/kg)], and G-CSF group [rats received ADR by the same route and the same dose as the previous group, and then G-CSF (70μg/kg/d) 2 hours after ADR injection then daily for five consecutive days]. At the time of sacrifice (after 6 weeks), blood samples were taken to estimate the blood urea nitrogen and serum creatinine. Kidney sections were stained with hematoxylin and eosin, toluidine blue, Masson's trichrome, periodic acid–Schiff stains, and immunohistochemical staining against CD34 and caspase-3. The G-CSF group exhibited protection against renal injury manifested by reducing blood urea nitrogen and serum-creatinine levels, improving histological architecture, and increasing the proliferative capacity of renal tubules