Connecting Contemporary Trauma Care to Florence Nightingale\u27s Visionary Work

The impact of Florence Nightingale\u27s visionary work continues to influence the delivery of nursing care in the contemporary emergency department (ED). Her foundational work in the Crimean War resulted in data-based recommendations for using the environment to promote healing and wellness among sick and wounded British soldiers. She advocated for attention to environmental details, including ventilation, air, warmth, drainage, cleanliness, natural light, and low noise levels. These important environmental concepts play a significant role in the nursing management of trauma patients in today\u27s ED. This article features an application of Nightingale\u27s environmental concepts to a trauma patient case exemplar and demonstrates the enduring impact of her work for trauma patients who receive care in the ED

EXC 006 Danny Mosley 4-27-2022

Acc #: 756; EXC 006 In this recording, Danny Mosley is interviewed by Jada Jones, Michael Campbell, and Willie Dinish in the McCall Library at the University of South Alabama about his experiences in the Excelsior Band. The interview begins with Mr. Mosely observing that he is one of the youngest members of the group. He talks about his experienced in the Vigor High School band, and how it educated him on HBCU culture, leading him to eventually attend Jackson State University. Near the conclusion of the interview, he reflects on the reasons that he decided to continue his career as a musician

Gameplay, Interactive Drama, and Training: Authoring Edutainment Stories for Online Players (AESOP)

This paper describes initial efforts at providing some of the technological advances of the videogame genres in a coherent, accessible format to teams of educators. By providing these capabilities inside an interactive drama generator, we believe that the full potential of educational games may eventually be realized. Sections 1 and 2 postulate three goals for reaching that objective: a toolset for interactive drama authoring, ways to insulate authors from game engines, and reusable digital casts to facilitate composability. Sections 3 and 4 present progress on those tools and an in-depth case study that made use of the resulting toolset to create a large interactive drama. We close with lessons learned to date and a look at the remaining challenges: the unpleasant reality that state-of-the-art tools are not yet able to boost the productivity of edutainment authors

Authoring Edutainment Stories for Online Players (AESOP): Introducing Gameplay into Interactive Dramas

The video gaming industry has experienced extraordinary technological growth in the recent past, causing a boom in both the quality and revenue of these games. Educational games, on the other hand, have lagged behind this trend, as their creation presents major creative and pedagogical challenges in addition to technological ones. By providing the technological advances of the entertainment genres in a coherent, accessible format to teams of educators, and developing an interactive drama generator, we believe that the full potential of educational games can be realized. Section 1 postulates three goals for reaching that objective: a toolset for interactive drama authoring, ways to insulate authors from game engines, and reusable digital casts to facilitate composability. Sections 2 and 3 present progress on simple versions of those tools and a case study that made use of the resulting toolset to create an interactive drama

Introduction: Aid?effectiveness, Prisoners' Dilemmas, and Country Allocations

SUMMARY In theory — and in project and country experience — aid has proved its potential to stimulate growth, and sometimes to reduce poverty. But the record has been worsening, for four reasons. First, donors' self?interest impedes their attempts to help recipients to improve policy. Second, each donor (and each recipient ministry), in pursuing its own interests, damages the total performance of aid. Third, the recent shifts from project to programme aid require better support with manpower training, and subtler concepts of ‘policy dialogue’. Finally, the growing scandal of country aid allocations needs attention. SOMMAIRE Introduction: l'efficacité de l'aide, les dilemmes de prisonnier, et l'allocation par pays En théorie — et en pratique (des projets et des pays) — l'aide a démontré le potentiel de stimuler la croissance, et a parfois réduit la pauvreté. Mais la situation s'est détériorée pour quatre raisons. D'abord, le propre intérêt des donneurs mine leurs efforts d'aider les pays recevants à améliorer leurs politiques. En second lieu, chaque donneur (et chaque ministère récipient), en agissant selon ses propres intérêts, amoindrit les résultats totaux de l'aide. Troisièmement, la réorientation récente de l'aide aux projets, vers de l'aide aux programmes, exige une soutenance améliorée, et des concepts plus raffinés de dialogue de la politique. Enfin, il faut tirer l'attention sur le scandal aggrandissant de l'allocation de l'aide par pays. RESUMEN Introducción: Efectividad de la ayuda, dilemas de los prisioneros y distribución por paises En teoría, así como en la experiencia relativa a proyectos y a países, la ayuda ha probado su potencialidad para estimular el crecimiento y, a veces, para reducir la pobreza. No obstante, los impactos positivos de la ayuda han ido menguando debido a cuatro razones. Primero, los intereses propios de los donantes interfieren sus intentos para ayudar a mejorar las políticas a los receptores. Segundo, cada donante (y cada ministerio receptor) al perseguir su propio interés, daña el resultado total de la ayuda. Tercero, los cambios recientes de la ayuda de proyectos a programas, requieren de un mejor apoyo que implica entrenamiento en capacitación y el concepto sutil ‘diálogo sobre politicas’. Finalmente, el creciente escándalo sobre la asignación de la ayuda por países, requiere atención

Position Measurement for a Relativistic Particle: Restricted-Path-Integral Analysis

Measurements of the position of a relativistic particle is considered in the framework of the Restricted-Path-Integral (RPI) approach. The amplitude describing such a measurement is shown to be exponentially small outside the light cone of the space-time point corresponding to the measurement output, in a qualitative agreement with the Hellwig and Kraus' postulate of relativistic state reduction. Theory of the measurement including the probability distribution for different measurement outputs is suggested. It is shown that correct theory does not exist (for arbitrary initial states) if the error of the measurement is less than the Compton length. The physical reason is that the picture of measurement is destroyed in this case by pair creation.Comment: 12 pages, LATE

A radioiodinated rucaparib analogue as an Auger electron emitter for cancer therapy

Introduction: Radioligand therapy (RLT) is an expanding field that has shown great potential in the fight against cancer. Radionuclides that can be carried by selective ligands such as antibodies, peptides, and small molecules targeting cancerous cells have demonstrated a clear improvement in the move towards precision medicine. Poly (ADP-ribose) polymerase (PARP) is a family of enzymes involved in DNA damage repair signalling pathway, with PARP inhibitors olaparib, talazoparib, niraparib, veliparib, and rucaparib having FDA approval for cancer therapy in routine clinical use. Based on our previous work with the radiolabelled PARP inhibitor [18F]rucaparib, we replaced the fluorine-18 moiety, used for PET imaging, with iodine-123, a radionuclide used for SPECT imaging and Auger electron therapy, resulting in 8-[123I]iodo-5-(4-((methylamino)methyl)phenyl)-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one, ([123I]GD1), as a potential radiopharmaceutical for RLT.Methods: [123I]GD1 was synthesized via copper-mediated radioiodination from a selected boronic esters precursor. In vitro uptake, retention, blocking, and effects on clonogenic survival with [123I]GD1 treatment were tested in a panel of cancer cell lines. Enzymatic inhibition of PARP by GD1 was also tested in a cell-free system. The biodistribution of [123I]GD1 was investigated by SPECT/CT in mice following intravenous administration.Results: Cell-free enzymatic inhibition and in vitro blocking experiments confirmed a modest ability of GD1 to inhibit PARP-1, IC50 = 239 nM. In vitro uptake of [123I]GD1 in different cell lines was dose dependent, and radiolabelled compound was retained in cells for &gt;2 h. Significantly reduced clonogenic survival was observed in vitro after exposure of cells for 1 h with as low as 50 kBq of [123I]GD1. The biodistribution of [123I]GD1 was further characterized in vivo showing both renal and hepatobiliary clearance pathways with a biphasic blood clearance.Conclusion: We present the development of a new theragnostic agent based on the rucaparib scaffold and its evaluation in in vitro and in vivo models. The data reported show that [123I]GD1 may have potential to be used as a theragnostic agent.</p

Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson\u27s disease.

Early diagnosis of Parkinson\u27s disease (PD) is required to improve therapeutic responses. Indeed, a clinical diagnosis of resting tremor, rigidity, movement and postural deficiencies usually reflect \u3e50% loss of the nigrostriatal system in disease. In a step to address this, quantitative diffusion tensor magnetic resonance imaging (DTI) was used to assess nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication model of dopaminergic nigral degeneration. We now demonstrate increased average diffusion (p\u3c0.005) and decreased fractional anisotropy (p\u3c0.03) in the substantia nigra (SN) of 5- to 7-day MPTP-treated animals when compared to saline controls. Transverse diffusivity demonstrated the most significant differences (p \u3c or = 0.002) and correlated with the numbers of SN dopaminergic neurons (r=-0.75, p=0.012). No differences were found in the striatum, corpus callosum, cerebral cortex, or ventricles. These results demonstrate that DTI may be used as a surrogate biomarker of nigral dopaminergic neuronal degeneration

Quantitative 1H magnetic resonance spectroscopic imaging determines therapeutic immunization efficacy in an animal model of Parkinson\u27s disease.

Nigrostriatal degeneration, the pathological hallmark of Parkinson\u27s disease (PD), is mirrored by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication. MPTP-treated animals show the common behavioral, motor, and pathological features of human disease. We demonstrated previously that adoptive transfer of Copaxone (Cop-1) immune cells protected the nigrostriatal dopaminergic pathway in MPTP-intoxicated mice. Herein, we evaluated this protection by quantitative proton magnetic resonance spectroscopic imaging (1H MRSI). 1H MRSI performed in MPTP-treated mice demonstrated that N-acetyl aspartate (NAA) was significantly diminished in the substantia nigra pars compacta (SNpc) and striatum, regions most affected in human disease. When the same regions were coregistered with immunohistochemical stains for tyrosine hydroxylase, numbers of neuronal bodies and termini were similarly diminished. MPTP-intoxicated animals that received Cop-1 immune cells showed NAA levels, in the SNpc and striatum, nearly equivalent to PBS-treated animals. Moreover, adoptive transfer of immune cells from ovalbumin-immunized to MPTP-treated mice failed to alter NAA levels or protect dopaminergic neurons and their projections. These results demonstrate that 1H MRSI can evaluate dopaminergic degeneration and its protection by Cop-1 immunization strategies. Most importantly, the results provide a monitoring system to assess therapeutic outcomes for PD