Genomic investigations of unexplained acute hepatitis in children

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children

Ally's subsequent behavior following sexist events.

Pre-registration for Study 2

“My Aim is True”: An Attribution-Identity Model of Ally Sincerity

Advantaged group allies can be beneficial to disadvantaged groups. However, allies have multiple motives for supporting equality, raising questions about their sincerity. In the present review, we draw upon the covariation model of attributions (Kelley, 1973) and self-categorization theory (Turner et al., 1987) to posit that disadvantaged group members view allies as sincere when allies support equality in ways that go beyond expectations for the advantaged group (low consensus) and exhibit consistent support across time (high consistency) and situations (low distinctiveness). Once deemed sincere, disadvantaged group members categorize advantaged group allies as partial ingroup members within a shared opinion-based group defined by support for equality (i.e., feminists). Categorizing advantaged group allies as partial ingroup members has a variety of benefits. Our Attribution-Identification Model of Ally Sincerity (AIMS) suggests how members of disadvantaged groups seek to maximize the benefits and minimize the costs of allyship

Cancer survivorship: A positive side-effect of more successful cancer treatment

AbstractOver the past decades, early diagnosis, new drugs and more personalised multi-modality treatment have led to impressive increases in survival rates of patients with cancer. This success in treating cancer has resulted in a large and rapidly increasing number of cancer survivors, yet life after cancer is often compromised by a broad spectrum of late adverse treatment effects. Some encounter cardiovascular, second malignancies, cognitive or other morbidities which impair normal life in an important way. Some patients are confronted with societal discrimination due to slower performance, chronic fatigue or partial inability and these things can adversely affect employment, education, insurance or mortgage opportunities.In 2012, the European Organisation of Research and Treatment of Cancer (EORTC) Survivorship Task Force was created to focus research efforts on late morbidity of cancer treatment and its impact on society. On 30–31st January 2014, the 1st EORTC Cancer Survivorship Summit was organised to facilitate interaction between clinicians, researchers, social workers, patients, insurers, bankers and policy makers. This important event addressed the needs of cancer survivors, and new collaborations between academic groups, patient advocates, financial and political representatives were formed to guide future European research and health policies in this field. This special issue of the European Journal of Cancer is entirely dedicated to this Summit and addresses, respectively, second malignancies, cardiovascular disease, cognitive dysfunction, infertility/sexuality and psycho-social problems following cancer treatment

Laboratories of Creativity: The Alma-Tademas' Studio-Houses and Beyond

This Conversation Piece highlights the range of new research discoveries that are being -- and are still to be -- made about artists’ studio homes. This conversation was first aired in a workshop at the Paul Mellon Centre in October 2017 when a group of invited curators, scholars, and students shared their research about the Alma-Tadema studio-houses, exploring how they were designed, used and re-used, unearthing many tantalising links to other studio-houses created or inhabited by artists of the previous, contemporary, and next generations. This Conversation Piece aims to recapture the sense of discovery that made that workshop so exciting, and also to make the speakers’ contributions available to wider audiences. It is coordinated by Elizabeth Prettejohn and Peter Trippi, who have published an extended introduction to the topic in this issue