101 research outputs found
Dual Stimuli-Responsive Dynamic Covalent Peptide Tags: Toward Sequence-Controlled Release in Tumor-like Microenvironments
In Situ Assembly of Platinum(II)-Metallopeptide Nanostructures Disrupts Energy Homeostasis and Cellular Metabolism
Betti numbers for numerical semigroup rings
We survey results related to the magnitude of the Betti numbers of numerical
semigroup rings and of their tangent cones.Comment: 22 pages; v2: updated references. To appear in Multigraded Algebra
and Applications (V. Ene, E. Miller Eds.
Rapporto allegato a PRG (Piano Regolatore Generale) Servizio di supporto alle attività del progetto MOLOC “Morphologies Low Carbon”, PROPOSTA TECNICA DEL PROGETTO PRELIMINARE, DOCUMENTAZIONE DI STUDIO - QUADERNO 6/2
Saccharomyces cerevisiae-based system for studying clustered DNA damages
DNA-damaging agents can induce clustered lesions or multiply damaged sites (MDSs) on the same or opposing DNA strands. In the latter, attempts to repair MDS can generate closely opposed single-strand break intermediates that may convert non-lethal or mutagenic base damage into double-strand breaks (DSBs). We constructed a diploid S. cerevisiae yeast strain with a chromosomal context targeted by integrative DNA fragments carrying different damages to determine whether closely opposed base damages are converted to DSBs following the outcomes of the homologous recombination repair pathway. As a model of MDS, we studied clustered uracil DNA damages with a known location and a defined distance separating the lesions. The system we describe might well be extended to assessing the repair of MDSs with different compositions, and to most of the complex DNA lesions induced by physical and chemical agents
Simulated 50Â % radiation dose reduction in coronary CT angiography using adaptive iterative dose reduction in three-dimensions (AIDR3D)
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