The GRAVITY young stellar object survey XIII. Tracing the time-variable asymmetric disk structure in the inner AU of the Herbig star HD98922

Temporal variability in the photometric and spectroscopic properties of protoplanetary disks is common in YSO. However, evidence pointing toward changes in their morphology over short timescales has only been found for a few sources, mainly due to a lack of high cadence observations at mas resolution. We combine GRAVITY multi-epoch observations of HD98922 at mas resolution with PIONIER archival data covering a total time span of 11 years. We interpret the interferometric visibilities and spectral energy distribution with geometrical models and through radiative transfer techniques. We investigated high-spectral-resolution quantities to obtain information on the properties of the HI BrG-line-emitting region. The observations are best fitted by a model of a crescent-like asymmetric dust feature located at 1 au and accounting for 70% of the NIR emission. The feature has an almost constant magnitude and orbits the central star with a possible sub-Keplerian period of 12 months, although a 9 month period is another, albeit less probable, solution. The radiative transfer models show that the emission originates from a small amount of carbon-rich (25%) silicates, or quantum-heated particles located in a low-density region. Among different possible scenarios, we favor hydrodynamical instabilities in the inner disk that can create a large vortex. The high spectral resolution differential phases in the BrG-line show that the hot-gas component is offset from the star and in some cases is located between the star and the crescent feature. The scale of the emission does not favor magnetospheric accretion as a driving mechanism. The scenario of an asymmetric disk wind or a massive accreting substellar or planetary companion is discussed. With this unique observational data set for HD98922, we reveal morphological variability in the innermost 2 au of its disk region.Comment: 45 pages, 20 figures, accepted by and to be published in Astronomy & Astrophysics (A&A

Carcinoma Oculto da Mama com Metástases Axilares. A Propósito de Dois Casos Clínicos

INTRODUÇÃO: O carcinoma oculto é uma entidade pouco frequente, que se define como a presença de metástases com tumor primário indetetável na altura da apresentação. O prognóstico da maioria dos casos de tumor oculto é reservado, no entanto, o desenvolvimento de técnicas imunohistoquímicas que permitem a caracterização do tumor, tornaram alguns subgrupos de tumor oculto potencialmente curáveis. A presença de adenopatias axilares é a forma de apresentação do cancro da mama em 0,3-1% das mulheres, sendo a origem mais provável a mama ipsilateral. CASO CLÍNICO: Os autores relatam dois casos clínicos de tumor oculto da mama: Caso 1: Doente de 57 anos, com antecedentes familiares de primeiro e segundo grau de cancro da mama, com estudo genético negativo. Recorreu à consulta por adenopatia axilar direita.Exame objetivo (EO), mamografia + ecografia mamária normais. Microbiópsia (MB) ganglionar:metástase de carcinoma compatível com origem na mama, recetores de estrogénios (RE) +, HER2 +, CK7 +, Ca125 +, CK20 (-). RMN mamária e PET não identificaram tumor primário. Procedeu-se a dissecção axilar: 10 gânglios sem metástases. Realizou terapêutica adjuvante com quimioterapia (QT) e imunoterapia (IT). Manteve follow-up regular com EO, RMN e mamografia alternadas até aos 4 anos sem alterações. Aos 4,5 anos detetou-se ao E.O. nódulo palpável na mama direita e nódulo axilar. Mamografia + ecografia: lesão sólida suspeita (R5) cuja caracterização histológicademonstrouCDIG3, recetores hormonais (-) (RH), HER2 3+, Ki67 >30%. A TC TAP e a cintigrafia óssea não revelaram alterações. Em reunião multidisciplinar de decisão terapêutica (RMDT) decidiu-serealizar mastectomia total direita + mastectomia profilática contralateral com reconstrução. Exame histológico:CDI G3 com 22mm,confirmando-se a caracterização imunohistoquímica, com invasão vascular e presença de 3 gânglios com metástase e extensão extracapsular (T2 N2). Realizou terapêutica adjuvante com QT + IT+ Radioterapia (RT) da parede torácica e ganglionar. Um ano após a mastectomia, a doente mantém-se em follow-up sem sinais de recidiva. Caso 2: Doente de 50 anos, com antecedentes familiares de primeiro grau de cancro da mama. Recorreu à consulta por nódulo da axila esquerda e nódulo da mama direita com 2 meses de evolução. EO: nódulo palpável da mama direita e duas adenopatias axilares à esquerda. Mamografia + eco: microcalcificações atípicas da mama esquerda (R5) ealterações benignas da mama direita (R2). Realizaram-se microbiópsia por estereotaxia e biópsia assistida por vácuo da mama esquerda e citologia aspirativa de agulha fina (CAAF) de nódulo da mama direita:sem alterações neoplásicas. A biópsia de adenopatia axilar revelou metástase ganglionar de carcinoma compatível com origem na mama, RH (-), GCDFP15 (-),HER2 3+ e CK7 +.A RM mamária revelou apenas lesões benignas. TC TAP, ecografia abdominal e cintigrafia óssea normais. PET: lesão localizada na axila esquerda, nos três níveis axilares. Por recusa da doente em realizar microbiópsias adicionais ou mastectomia radical modificada, optou-se por realizar dissecção axilar esquerda. Exame histológico: 7 em 14 gânglios com metástases, morfologia e estudo imunohistoquímico concordantes com o anterior. Em RMDT foi decidida terapêuticaadjuvante com RT, QT e IT que a doente se encontra no momento a realizar. DIAGNÓSTICOS DIFERENCIAIS/ DISCUSSÃO A presença de adenopatias axilares relaciona-se na maioria dos casos com processos benignos, mas naqueles em que se diagnostica uma neoplasia maligna, mais de 50% correspondem a carcinoma da mama. Outras neoplasias que se podem apresentar com metástases axilares são: linfoma, melanoma, sarcoma, tiróide, pulmão, estômago, ovário, útero. A avaliação diagnóstica deve incluir além do exame físico, a biópsia ganglionar (para exame histológico e caracterização imunohistoquímica), mamografia, ecografia mamária e ressonância magnética mamária, eventual TC toraco-abdominal, cintigrafia óssea nas mulheres sintomáticas, existindo controvérsia sobre autilidade da PET. CONCLUSÕES O tumor oculto representa um problema diagnóstico e um desafio terapêutico. O carcinoma da mama apresentando-se sob a forma de metástase axilar sem tumor primário identificável e sem doença à distância, considera-se um dos casos potencialmente curáveis, se for tratado de acordo com as guidelines para o estadio II do cancro da mama. A abordagem recomendada inclui dissecção axilar, de importância crucial pela informação prognóstica que guiará o restante tratamento e por ajudar no controlo local da doença. A terapêutica adequada da mama ipsilateral é controversa, e pode passar pela mastectomia radical modificada ou RT. Não existem até à data estudos randomizados comparando a mastectomia versus RT mamária e os estudos retrospetivos disponíveis não apresentam resultados consensuais. A decisão de RT da parede torácica pós-mastectomia e de terapêutica adjuvante deverá ser tomada tendo em conta as guidelines publicadas. BIBLIOGRAFIA 1- www.uptodate.com; Kaklamani, V., et al; “Axillary node metastases with occult primary breast cancer”; Mar 2012 2- Wang, J., et al; “Occult breast cancer presenting as metastatic adenocarcinoma of unknown primary: clinical presentation, immunohistochemistry, and molecular analysis”; Case Rep Oncol 2012;5:9-16 3- Takabatake, D.; “Two cases of occult breast cancer in which PET-CT was helpful in identifying primary tumors”; Breast Cancer (2008) 15:181-184 4- Kinoshita, S., et al.; “Metachronous secondary primary occult breast cancer initially presenting with metastases to the contralateral axillary lymph nodes: report of a case”; Breast Cancer (2010) 17:71-74 5- Bresser, J., et al; “Breast MRI in clinically and mammographically occult breast cancer presenting with an axillary metastasis: a systematic review”; EJSO 36 (2010) 114-119 6- Sharon, W., et al.; “Benefit of ultrasonography in the detection of clinically and mammographically occult breast cancer”; World J Surg (2008) 32:2593-2598 7- Masinghe, S.P., et al.; “Breast radiotherapy for occult breast cancer with axillary nodal metastases – does it reduce the local recurrence rate and increase overall survival?”; Clinical Oncology 23 (2011) 95-100 8- Altan, E., et al.; “Clinical and pathological characteristics of occult breast cancer and review of the literature”; J Buon 2011 Jul-Sep;16(3):434-

Upgrading the GRAVITY fringe tracker for GRAVITY+ - Tracking the white-light fringe in the non-observable optical path length state-space

International audienceContext. The GRAVITY beam-combiner at the Very Large Telescope Interferometer has recently made important contributions to many different fields of astronomy, from observations of the Galactic centre to the study of massive stars, young stellar objects, exoplanet atmospheres, and active galactic nuclei. These achievements were only made possible by the development of several key technologies, including the development of reliable and high-performance fringe trackers. These systems compensate for disturbances ranging from atmospheric turbulence to vibrations in the optical system, enabling long exposures and ensuring the stability of interferometric measurements.Aims. As part of the ongoing GRAVITY+ upgrade of the Very Large Telescope Interferometer infrastructure, we aim to improve the performance of the GRAVITY fringe tracker, and to enable its use by other instruments.Methods. We modified the group-delay controller to consistently maintain tracking in the white-light fringe, which is characterised by a minimum group delay. Additionally, we introduced a novel approach in which fringe-tracking is performed in the non-observable optical path length state-space using a covariance-weighted Kalman filter and an auto-regressive model of the disturbance. We outline this new state-space representation and the formalism we used to propagate the state vector and generate the control signal. While our approach is presented specifically in the context of GRAVITY/GRAVITY+, it can easily be adapted to other instruments or interfero-metric facilities.Results. We successfully demonstrate phase-delay tracking within a single fringe, with any spurious phase jumps detected and corrected in less than 100 ms. We also report a significant performance improvement, as shown by a reduction of ~30 to 40% in phase residuals, and a much better behaviour under sub-optimal atmospheric conditions. Compared to what was observed in 2019, the median residuals have decreased from 150 nm to 100 nm on the Auxiliary Telescopes and from 250 nm to 150 nm on the Unit Telescopes.Conclusions. The improved phase-delay tracking combined with white-light fringe tracking means that from now on, the GRAVITY fringe tracker can be used by other instruments operating in different wavebands. The only limitation remains the need for an adjustment of the optical path dispersion.Key words: instrumentation: high angular resolution / instrumentation: interferometers / techniques: interferometric★ These authors contributed equally

Mid-infrared evidence for iron-rich dust in the multi-ringed inner disk of HD 144432

International audienceContext. Rocky planets form by the concentration of solid particles in the inner few au regions of planet-forming disks. Their chemical composition reflects the materials in the disk available in the solid phase at the time the planets were forming. Studying the dust before it gets incorporated in planets provides a valuable diagnostic for the material composition. Aims. We aim to constrain the structure and dust composition of the inner disk of the young Herbig Ae star HD 144432, using an extensive set of infrared interferometric data taken by the Very Large Telescope Interferometer (VLTI), combining PIONIER, GRAVITY, and MATISSE observations. Methods. We introduced a new physical disk model, TGMdust , to image the interferometric data, and to fit the disk structure and dust composition. We also performed equilibrium condensation calculations with GGchem to assess the hidden diversity of minerals occurring in a planet-forming disk such as HD 144432. Results. Our best-fit model has three disk zones with ring-like structures at 0.15, 1.3, and 4.1 au. Assuming that the dark regions in the disk at ~0.9 au and at ~3 au are gaps opened by planets, we estimate the masses of the putative gap-opening planets to be around a Jupiter mass. We find evidence for an optically thin emission (τ 3 µm. Our silicate compositional fits confirm radial mineralogy gradients, as for the mass fraction of crystalline silicates we get around 61% in the innermost zone ( r 300 K). Conclusions. We propose that in the warm inner regions ( r < 5 au) of typical planet-forming disks, most if not all carbon is in the gas phase, while iron and iron sulfide grains are major constituents of the solid mixture along with forsterite and enstatite. Our analysis demonstrates the need for detailed studies of the dust in inner disks with new mid-infrared instruments such as MATISSE and JWST/MIRI