Familial Ménière's disease: clinical and genetic aspects

ABSTRACT Background and purpose:Mre's disease is not uncommon, with an incidence in Caucasians of about one in 2000. The incidence peaks in the fifth decade. Cases are usually isolated or sporadic, but in perhaps five per cent other family members are affected. We report here the clinical and genetic characteristics of a comprehensive set of familial Mre's disease cases from the UK.Methods:Forty-six affected families were studied. All cases were diagnosed using the American Academy of Otolaryngolog 8211;Head and Neck Surgery committee on hearing and equilibrium 1995, or more stringent, criteria.Outcomes and results:Autosomal dominant inheritance with reduced penetrance was the most likely mode of inheritance overall. Apparent genetic anticipation was observed, but may also be a result of ascertainment bias given the collection strategy. There was also a slight tendency for cases to result from maternal transmission within the families in this set. The family pedigrees are presented, and the authors have also set up a website at which all the pedigrees may be viewed in greater detai

On Krein-like theorems for noncanonical Hamiltonian systems with continuous spectra: application to Vlasov-Poisson

The notions of spectral stability and the spectrum for the Vlasov-Poisson system linearized about homogeneous equilibria, f_0(v), are reviewed. Structural stability is reviewed and applied to perturbations of the linearized Vlasov operator through perturbations of f_0. We prove that for each f_0 there is an arbitrarily small delta f_0' in W^{1,1}(R) such that f_0+delta f_0$is unstable. When$f_0$ is perturbed by an area preserving rearrangement, f_0 will always be stable if the continuous spectrum is only of positive signature, where the signature of the continuous spectrum is defined as in previous work. If there is a signature change, then there is a rearrangement of f_0 that is unstable and arbitrarily close to f_0 with f_0' in W^{1,1}. This result is analogous to Krein's theorem for the continuous spectrum. We prove that if a discrete mode embedded in the continuous spectrum is surrounded by the opposite signature there is an infinitesimal perturbation in C^n norm that makes f_0 unstable. If f_0 is stable we prove that the signature of every discrete mode is the opposite of the continuum surrounding it.Comment: Submitted to the journal Transport Theory and Statistical Physics. 36 pages, 12 figure

Aerospace management techniques: Commercial and governmental applications

A guidebook for managers and administrators is presented as a source of useful information on new management methods in business, industry, and government. The major topics discussed include: actual and potential applications of aerospace management techniques to commercial and governmental organizations; aerospace management techniques and their use within the aerospace sector; and the aerospace sector's application of innovative management techniques

Loss Aversion and Intertemporal Choice: A Laboratory Investigation

We present results from a laboratory study of loss aversion in the context of intertemporal choice. We investigate whether the provision of (windfall) endowments results in different elicited discount rates relative to subjects who earn income or earn and retain the income for a period before making intertemporal decisions. We hypothesize that loss aversion in an intertemporal choice yields higher discount rates among subjects earning and retaining. Our results support this hypothesis: among subjects who earn and retain their income we elicit substantially higher discount rates relative to those experiencing a windfall gain.intertemporal choice, discount rates, experiments

Theory and applications of the Vlasov equation

Forty articles have been recently published in EPJD as contributions to the topical issue "Theory and applications of the Vlasov equation". The aim of this topical issue was to provide a forum for the presentation of a broad variety of scientific results involving the Vlasov equation. In this editorial, after some introductory notes, a brief account is given of the main points addressed in these papers and of the perspectives they open.Comment: Editoria

A study of poultry processing plant noise control techniques

A number of techniques can be used to reduce noise in poultry processing plants. In general, covering the ceiling with a noise-absorbing medium is a practical first step. Once the reflected noise levels are abated, treatment of specific identifiable noise courses can take place. The development, flammability, and mechanical properties of acoustic panels to be vertically suspended from the ceiling are discussed as well as the covers need to comply with USDA cleanability requirements. The isolation of drive motors and pumps from large expansive areas, the muffling of pneumatic devices, and the insulation of ice chutes are methods of source quieting. Proper maintenance of machinery and vibration monitoring are also needed to reduce hearing damage risk and to improve worker productivity and employee/supervisor relations