An investigation into the relationship between small intestinal fluid secretion and systemic arterial blood pressure in the anesthetized rat

In the absence of an ability to absorb fluid by cellular uptake mechanisms, fluid movement in vivo from the perfused rat intestine is absorptive when the diastolic blood pressure is normal or very low but is secretory when blood pressure falls below normal. This pattern of fluid movement is consistent with changes in capillary pressure within the villus. Whether flow moves into or out of the intestine is determined by changes in the Starling forces across intestinal capillaries. These observations indicate that secretion caused by some bacterial enterotoxins may act solely on the vasculature of the small intestine. This contradicts a major current theory of secretion that requires the source of the fluid to be from the epithelial cell. The significance of this work is that the intestinal arterioles rather than the epithelial cells may determine secretion. If substantiated, this may allow the development of the effective anti-secretory drugs that have not been forthcoming with development strategies based on the enterocyte model of deranged intestinal secretion

The Renaissance of Bacillosamine and Its Derivatives: Pathway Characterization and Implications in Pathogenicity

Prokaryote-specific sugars, including N,N′-diacetylbacillosamine (diNAcBac) and pseudaminic acid, have experienced a renaissance in the past decade because of their discovery in glycans related to microbial pathogenicity. DiNAcBac is found at the reducing end of oligosaccharides of N- and O-linked bacterial protein glycosylation pathways of Gram-negative pathogens, including Campylobacter jejuni and Neisseria gonorrhoeae. Further derivatization of diNAcBac results in the nonulosonic acid known as legionaminic acid, which was first characterized in the O-antigen of the lipopolysaccharide (LPS) in Legionella pneumophila. Pseudaminic acid, an isomer of legionaminic acid, is also important in pathogenic bacteria such as Helicobacter pylori because of its occurrence in O-linked glycosylation of flagellin proteins, which plays an important role in flagellar assembly and motility. Here, we present recent advances in the characterization of the biosynthetic pathways leading to these highly modified sugars and investigation of the roles that each plays in bacterial fitness and pathogenicity.National Institutes of Health (U.S.) (NIH BiotechnologyTraining Program T32-GM08334)National Institutes of Health (U.S.) (NIH Grant GM097241

Importance of understanding variable and transient energy demand in large multi-product industrial plants for process integration

There have been some news releases claiming that Professor Henle in Germany has found the chemical identity of UMF, and that in future chemical analysis will be used instead of assays of antibacterial activity to indicate the level of UMF in manuka honey. Both of these claims are misleading. Because the level of active substance in manuka honey is an unreliable indication of the level of antibacterial activity and can be very misleading, it is hard to see any commercial advantage for it to be used to indicate antibacterial activity other than if someone wanted to fool the consumer into thinking that the higher numbers are giving them a level of antibacterial activity that is far higher than they are really getting

Non-continuous and variable rate processes: Optimisation for energy use

The need to develop new and improved ways of reducing energy use and increasing energy intensity in industrial processes is currently a major issue in New Zealand. Little attention has been given to optimisation of non-continuous processes in the past, due to their complexity, yet they remain an essential and often energy intensive component of many industrial sites. Novel models based on pinch analysis that aid in minimising utility usage have been constructed here through the adaptation of proven continuous techniques. The knowledge has been integrated into a user friendly software package, and allows the optimisation of processes under variable operating rates and batch conditions. An example problem demonstrates the improvements in energy use that can be gained when using these techniques to analyse non-continuous data. A comparison with results achieved using a pseudo-continuous method show that the method described can provide simultaneous reductions in capital and operating costs

A derivative method for minimising total cost in heat exchanger networks through optimal area allocation

This paper presents a novel Cost Derivative Method (CDM) for finding the optimal area allocation for a defined Heat Exchanger Network (HEN) structure and stream data, without any stream splits to achieve minimum total cost. Using the Pinch Design Method (PDM) to determine the HEN structure, the approach attempts to add, remove and shift area to exchangers where economic benefits are returned. From the derivation of the method, it is found that the slope of the ε-NTU relationship for the specific heat exchanger type, in combination with the difference in exchanger inlet temperatures and the overall heat transfer coefficient, are critical to calculating the extra overall duty each incremental area element returns. The approach is able to account for differences in film coefficients, heat exchanger types, flow arrangements, exchanger cost functions, and utility pricing. Incorporated into the method is the newly defined “utility cost savings flow-on” factor, θ, which evaluates downstream effects on utility use and cost that are caused by changing the area of one exchanger. To illustrate the method, the CDM is applied to the distillation example of Gundersen (2000). After applying the new CDM, the total annual cost was reduced by 7.1 % mainly due to 24 % less HEN area for similar heat recovery. Area reduction resulted from one exchanger having a minimum approach temperature (ΔTmin) of 7.7 °C while the other recovery exchangers had larger ΔTmin values. The optimum ΔTmin for the PDM was 12.5 °C. The CDM solution was found to give a comparable minimum total area and cost to two recently published programming HEN synthesis solutions for the same problem without requiring the increased network complexity through multiple stream splits

Electronic Cash In E-Commerce: Comparative Analysis Of Views Of Hispanic And African-American Business Owners

Based on a survey of 1000 Hispanic and 1000 African-American business owners on the impacts e-commerce and e-cash are expected to have upon business practices, there were significant discrepancies between perceptions of these two groups regarding their ability to track and retain customers and to authenticate the source of e-cash payments.  In addition, while both groups of owners agreed that e-cash will likely replace traditional currency used in commercial transactions between consumers and business, they both are uncertain as to what degree central banks of countries should regulate and how much freedom the private sector should have for developing new forms of e-cash.  Hispanic business owners generally are more receptive to e-commerce viewing it as not making marketing strategies more difficult while African-American owners generally perceive enhanced issues to be resolved

Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis

Alpha-1 antitrypsin deficiency (AATD) is a cause of bronchiectasis. Guidelines for bronchiectasis from the British Thoracic Society do not recommend to routinely test patients for AATD. In contrast, guidelines for AATD recommend routine screening. This contradiction, in part, results from the lack of data from large studies performing comprehensive screening. We screened 1600 patients with bronchiectasis at two centres in the UK from 2012 to 2016. In total, only eight individuals with AATD were identified representing 0.5% of the overall population. We conclude that routine screening for AATD in bronchiectasis in the UK has a low rate of detection. Further studies are required in different geographical regions, which may have a higher prevalence of AATD.info:eu-repo/semantics/publishedVersio

Schoolwide Positive Behavioral Interventions and Supports in an Alternative Education Setting: Examining the Risk and Protective Factors of Responders and Non-Responders

This research examined the risk and protective factors of responders and nonresponders to a schoolwide implementation of positive behavioral interventions and supports (SW-PBIS) within an alternative school. Students completed self-perception measures of individual, school, community, and home systems. Multivariate analysis of variance indicated a statistically significant difference between responders and nonresponders on the individual and school systems models. Direct logistic regression indicated that within these models, hostility, destructive expression of anger, depression, academic self-concept, attitude to teachers, and attitude to school each made a significant contribution in identifying responders and nonresponders. Findings suggest that factors at the individual and school levels may be crucial in identifying individuals who respond favorably to SW-PBIS. Interventions that target specific risk factors may improve responsiveness to SW-PBIS in alternative schools