Animal Rights Philosophy versus Biological Reality

Veterinary medicine stands opposed to the concept of animal rights, although a number will readily contest this statement. Opposition comes from a misunderstanding of the veterinarian\u27s role in society and a lack of knowledge of what the animal rights philosophy demands. Properly understood, it is diametrically opposed to the Veterinarian\u27s Oath, which enjoins us to participate in the advancement of medical knowledge. We cannot do this and meet the demands of the animal rights movement

A Material History of the Early Eighteenth-Century Cod Fishery in Canso, Nova Scotia

In the early eighteenth century, Canso, Nova Scotia housed an influential Anglo-American fishing and trading community with far-reaching connections across Europe and the Americas. The islands were inhabited by a small permanent population joined each year by hundreds of migratory workers who established seasonal operations along their shores. Despite high hopes for long-term development, success would be short lived. Canso was a volatile space: the islands were contested territory and existed within a tense and turbulent frontier. The settlement was attacked multiple times and was destroyed in 1744. This paper draws upon new research and previous archaeological studies to discuss the social history and material life of the early eighteenth-century Canso fishery; in particular it focuses on the consumption patterns and living conditions of those who lived within this frontier community

Precision Calibration of Radio Interferometers Using Redundant Baselines

Growing interest in 21 cm tomography has led to the design and construction of broadband radio interferometers with low noise, moderate angular resolution, high spectral resolution, and wide fields of view. With characteristics somewhat different from traditional radio instruments, these interferometers may require new calibration techniques in order to reach their design sensitivities. Self-calibration or redundant calibration techniques that allow an instrument to be calibrated off complicated sky emission structures are ideal. In particular, the large number of redundant baselines possessed by these new instruments makes redundant calibration an especially attractive option. In this paper, we explore the errors and biases in existing redundant calibration schemes through simulations, and show how statistical biases can be eliminated. We also develop a general calibration formalism that includes both redundant baseline methods and basic point source calibration methods as special cases, and show how slight deviations from perfect redundancy and coplanarity can be taken into account.Comment: 18 pages, 13 figures; Replaced to match accepted MNRAS versio

Animals and Medicine

Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives—both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine—from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer. This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present

From workplace to home space: archaeology at the James M. Rogers sawmill, Scots Bay, Nova Scotia (BhDc-16)

When Nova Scotia’s lumber industry peaked in the mid to late nineteenth century, water powered sawmills could be found on essentially every river, brook, or stream in the province. While large-scale sawmills were important to the greater economy, mills varied in size and function: there were hundreds of small, family-run operations sawing for local use. Regardless of size, most were influential to their immediate communities, providing employment and necessary building materials. In an effort to learn more about these small-scale enterprises, and their wider implications, an archaeological investigation was carried out the site of the James M. Rogers Sawmill (BhDc-16), in Scots Bay, Kings County. Built in the late 1850s or early 1860s, the James M. Rogers Sawmill was used opportunistically to supplement an income made primarily through agricultural activities. Research at the site focused on three primary objectives: determining the layout and scale of the mill; establishing the operation’s function within its owners overall economic strategy; and situating the sawmill within Scots Bay’s wider industrial economy

GNSS-Denied Navigation using Direction of Arrival from Low-Cost Software Defined Radios and Signals of Opportunity

This paper describes a novel navigation system for outdoor navigation in conditions where reliable satellite navigation cannot be assumed. It is build around inexpensive of-the-shelf hardware and could be used with several different signal types, allowing flexibility in usage. The system is currently in a proof-of-concept stage, and this paper shows that there are promising preliminary results.acceptedVersio

Haematopoietic stem cells require a highly regulated protein synthesis rate

Many aspects of cellular physiology remain unstudied in somatic stem cells. For example, there are almost no data on protein synthesis in any somatic stem cell. We found that the amount of protein synthesized per hour in haematopoietic stem cells (HSCs) in vivo was lower than in most other haematopoietic cells, even if we controlled for differences in cell cycle status or forced HSCs to undergo self-renewing divisions. Reduced ribosome function in Rpl24Bst/+ mice further reduced protein synthesis in HSCs and impaired HSC function. Pten deletion increased protein synthesis in HSCs but also reduced HSC function. Rpl24Bst/+ cell-autonomously rescued the effects of Pten deletion in HSCs, blocking the increase in protein synthesis, restoring HSC function, and delaying leukaemogenesis. Pten deficiency thus depletes HSCs and promotes leukaemia partly by increasing protein synthesis. Either increased or decreased protein synthesis impairs HSC function

The transcriptional response to encystation stimuli in Giardia lamblia is restricted to a small set of genes

Author Posting. © The Author(s), 2010. This is the author's version of the work. It is posted here by permission of American Society for Microbiology for personal use, not for redistribution. The definitive version was published in Eukaryotic Cell 9 (2010): 1566-1576, doi:10.1128/EC.00100-10.The protozoan parasite Giardia lamblia undergoes stage-differentiation in the small intestine of the host to an environmentally resistant and infectious cyst. Encystation involves secretion of an extracellular matrix comprised of cyst wall proteins (CWPs) and a β(1-3)-GalNAc homopolymer. Upon induction of encystation, genes coding for CWPs are switched on, and mRNAs coding for a transcription factor Myb and enzymes involved in cyst wall glycan synthesis are upregulated. Encystation in vitro is triggered by several protocols, which call for changes in bile concentrations or availability of lipids, and elevated pH. However, the conditions for induction are not standardized and we predicted significant protocol-specific side effects. This makes reliable identification of encystation factors difficult. Here, we exploited the possibility to induce encystation with two different protocols, which we show to be equally effective, for a comparative mRNA profile analysis. The standard encystation protocol induced a bipartite transcriptional response with surprisingly minor involvement of stress genes. A comparative analysis revealed a core set of only 18 encystation genes and showed that a majority of genes was indeed upregulated as a side effect of inducing conditions. We also established a Myb binding sequence as a signature motif in encystation promoters, suggesting coordinated regulation of these factors.We acknowledge in particular the “Stiftung zur Förderung der Wissenschaftlichen Forschung an der Universität Zürich” for financial support for this project. C.S. was supported by the Roche and Novartis Foundation, and “Stiftung für Forschungsförderung” University of Zurich. Research in the Hehl laboratory is supported by the Swiss National Science Foundation (grant #31003A-125389)

A Model for Simulating the Thermal and Electrical Production of Small-Scale Solid-Oxide Fuel Cell Cogeneration Systems within Building Simulation Programs

A new model for predicting the thermal and electrical performance of solid-oxide fuel cell(SOFC) cogeneration devices for residential buildings has been developed and demonstrated. This is a system-level model that considers the thermodynamic performance of all components that consume energy and produce the thermal and electrical output of the SOFC-cogeneration device. The model relies heavily upon empirical information that can be acquired from the testing of coherent systems or components and is designed for operation at a time resolution that is in the order of minutes. Hence, it is appropriate for use in whole-building simulation programs, where it can be applied to assess the energy and greenhouse gas emission benefits of this nascent technology

Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)

Background: Amyotrophic lateral sclerosis (ALS), a common late-onset neurodegenerative disease, is associated with fronto-temporal dementia (FTD) in 3-10% of patients. A mutation in CHMP2B was recently identified in a Danish pedigree with autosomal dominant FTD. Subsequently, two unrelated patients with familial ALS, one of whom also showed features of FTD, were shown to carry missense mutations in CHMP2B. The initial aim of this study was to determine whether mutations in CHMP2B contribute more broadly to ALS pathogenesis. Methodology/Principal Findings: Sequencing of CHMP2B in 433 ALS cases from the North of England identified 4 cases carrying 3 missense mutations, including one novel mutation, p. Thr104Asn, none of which were present in 500 neurologically normal controls. Analysis of clinical and neuropathological data of these 4 cases showed a phenotype consistent with the lower motor neuron predominant (progressive muscular atrophy (PMA)) variant of ALS. Only one had a recognised family history of ALS and none had clinically apparent dementia. Microarray analysis of motor neurons from CHMP2B cases, compared to controls, showed a distinct gene expression signature with significant differential expression predicting disassembly of cell structure; increased calcium concentration in the ER lumen; decrease in the availability of ATP; down-regulation of the classical and p38 MAPK signalling pathways, reduction in autophagy initiation and a global repression of translation. Transfection of mutant CHMP2B into HEK-293 and COS-7 cells resulted in the formation of large cytoplasmic vacuoles, aberrant lysosomal localisation demonstrated by CD63 staining and impairment of autophagy indicated by increased levels of LC3-II protein. These changes were absent in control cells transfected with wild-type CHMP2B. Conclusions/Significance: We conclude that in a population drawn from North of England pathogenic CHMP2B mutations are found in approximately 1% of cases of ALS and 10% of those with lower motor neuron predominant ALS. We provide a body of evidence indicating the likely pathogenicity of the reported gene alterations. However, absolute confirmation of pathogenicity requires further evidence, including documentation of familial transmission in ALS pedigrees which might be most fruitfully explored in cases with a LMN predominant phenotype