Hunting for dark matter and new physics with GECCO

We outline the science opportunities in the areas of searches for dark matter and new physics offered by a proposed future MeV gamma-ray telescope, the Galactic Explorer with a Coded Aperture Mask Compton Telescope (GECCO). We point out that such an instrument would play a critical role in opening up a discovery window for particle dark matter with mass in the MeV or sub-MeV range, in disentangling the origin of the mysterious 511 keV line emission in the Galactic Center region, and in potentially discovering Hawking evaporation from light primordial black holes

Penrose Limits of Orbifolds and Orientifolds

We study the Penrose limit of various AdS_p X S^q orbifolds. The limiting spaces are waves with parallel rays and singular wave fronts. In particular, we consider the orbifolds AdS_3 X S^3/\Gamma, AdS_5 X S^5/\Gamma and AdS_{4,7} X S^{7,4}/\Gamma where \Gamma acts on the sphere and/or the AdS factor. In the pp-wave limit, the wave fronts are the orbifolds C^2/\Gamma, C^4/\Gamma and R XC^4/\Gamma, respectively. When desingularization is possible, we get asymptotically locally pp-wave backgrounds (ALpp). The Penrose limit of orientifolds are also discussed. In the AdS_5 X RP^5 case, the limiting singularity can be resolved by an Eguchi-Hanson gravitational instanton. The pp-wave limit of D3-branes near singularities in F-theory is also presented. Finally, we give the embedding of D-dimensional pp-waves in flat M^{2,D} space.Comment: 20 pages, references adde

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes

Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further, plant parasitic nematodes result in major crop damage. The pipeline of therapeutic compounds is limited and parasite resistance to the existing anthelmintic compounds is a global threat. We have developed an INVertebrate Automated Phenotyping Platform (INVAPP) for high-throughput, plate-based chemical screening, and an algorithm (Paragon) which allows screening for compounds that have an effect on motility and development of parasitic worms. We have validated its utility by determining the efficacy of a panel of known anthelmintics against model and parasitic nematodes: Caenorhabditis elegans, Haemonchus contortus, Teladorsagia circumcincta, and Trichuris muris. We then applied the system to screen the Pathogen Box chemical library in a blinded fashion and identified compounds already known to have anthelmintic or anti-parasitic activity, including tolfenpyrad, auranofin, and mebendazole; and 14 compounds previously undescribed as anthelmintics, including benzoxaborole and isoxazole chemotypes. This system offers an effective, high-throughput system for the discovery of novel anthelmintics

Ricci-flat deformation of orbifolds and localized tachyonic modes

We study Ricci-flat deformations of orbifolds in type II theory. We obtain a simple formula for mass corrections to the twisted modes due to the deformations, and apply it to originally tachyonic and massless states in several examples. In the case of supersymmetric orbifolds, we find that tachyonic states appear when the deformation breaks all the supersymmetries. We also study nonsupersymmetric orbifolds C^2/Z_{2N(2N+1)}, which is T-dual to N type 0 NS5-branes. For N>=2, we compute mass corrections for states, which have string scale tachyonic masses. We find that the corrected masses coincide to ones obtained by solving the wave equation for the tachyon field in the smeared type 0 NS5-brane background geometry. For N=1, we show that the unstable mode representing the bubble creation is the unique tachyonic mode.Comment: 20 pages, minor collection

Systematic model behavior of adsorption on flat surfaces

A low density film on a flat surface is described by an expansion involving the first four virial coefficients. The first coefficient (alone) yields the Henry's law regime, while the next three correct for the effects of interactions. The results permit exploration of the idea of universal adsorption behavior, which is compared with experimental data for a number of systems

Липоидный некробиоз (болезнь Оппенгейма — урбаха)

Etiology, pathogenesis, clinical and pathomorphological criteria of diagnostics of necrobiosis lipoidica are described. The case of own supervision is presented.Описаны этиология, патогенез, клинические и патоморфологические критерии диагностики липоидного некробиоза, принципы терапии заболевания. Приведен случай собственного наблюдения

Лимфоматоидный папулез

Etiology, pathogenesis, clinical and pathomorphological criteria of diagnostics of lymphomatoid papulosis are described. The case of own supervision is presented.Описаны этиология, патогенез, клинические и патоморфологические критерии диагностики лимфоматоидного папулеза, принципы терапии заболевания. Приведен случай собственного наблюдения

Topological Field Theory and Rational Curves

We analyze the superstring propagating on a Calabi-Yau threefold. This theory naturally leads to the consideration of Witten's topological non-linear sigma-model and the structure of rational curves on the Calabi-Yau manifold. We study in detail the case of the world-sheet of the string being mapped to a multiple cover of an isolated rational curve and we show that a natural compactification of the moduli space of such a multiple cover leads to a formula in agreement with a conjecture by Candelas, de la Ossa, Green and Parkes.Comment: 20 page

Exceptional collections and D-branes probing toric singularities

We demonstrate that a strongly exceptional collection on a singular toric surface can be used to derive the gauge theory on a stack of D3-branes probing the Calabi-Yau singularity caused by the surface shrinking to zero size. A strongly exceptional collection, i.e., an ordered set of sheaves satisfying special mapping properties, gives a convenient basis of D-branes. We find such collections and analyze the gauge theories for weighted projective spaces, and many of the Y^{p,q} and L^{p,q,r} spaces. In particular, we prove the strong exceptionality for all p in the Y^{p,p-1} case, and similarly for the Y^{p,p-2r} case.Comment: 49 pages, 6 figures; v2 refs added; v3 published versio

AdS Branes Corresponding to Superconformal Defects

We investigate an AdS_4 x L_2 D5-brane in AdS_5 x X_5 space-time, in the context of AdS/dCFT correspondence. Here, X_5 is a Sasaki-Einstein manifold and L_2 is a submanifold of X_5. This brane has the same supersymmetry as the 3-dimensional N=1 superconformal symmetry if L_2 is a special Legendrian submanifold in X_5. In this case, this brane is supposed to correspond to a superconformal wall defect in 4-dimensional N=4 super Yang-Mills theory. We construct these new string backgrounds and show they have the correct supersymmetry, also in the case with non-trivial gauge flux on L_2. The simplest new example is AdS_4 x T^2 brane in AdS_5 x S^5. We construct the brane solution expressing the RG flow between two different defects. We also perform similar analysis for an AdS_3 x L_3 M5-brane in AdS_4 x X_7, for a weak G_2 manifold X_7 and its submanifold L_3. This system has the same supersymmetry as 2-dimensional N=(1,0) global superconformal symmetry, if L_3 is an associative submanifold.Comment: 22 pages, LaTeX, 3 figures. v2: typos corrected, references added. v3: typos correcte