Neuroprotezione del paziente con glaucoma cronico ad angolo aperto:ruolo della Citicolina in soluzione orale

Aim: To verify the efficacy of Citicoline, taken orally, in the prevention of neurological damage in patients with Chronic Open Angle Glaucoma (COA G). Methods: 30 subjects with COA G were divided into 2 groups: 18 subjects (CT group) were treated with Citicoline and 12 (PP group) were treated with placebo. Both groups underwent 3 cycles of treatment. A cycle lasted 60 days and after every cycle there was a wash-out period of 30 days. On day 0, 60, 90, 150, 180, 240 and 270 all subjects underwent an examination of the optic nerve fibres by GDx VVC and a simultaneous recording of pattern reversal VEP s and pattern ER G. Results: In both groups endocular pressure values kept steady below 21 mmHg. In the CT group the VEP s average amplitude regularly increased at the end of every cycle and moderately decreased at the end of the wash-out period. Retinocortical Time (RCT ) appeared significantly reduced at the end of every cycle in the CT group. VEP s average amplitude and RCT remained unchanged in the PP group. A slowing down of the TSNIT average, statistically non significant, appeared only at the end of the third cycle in the CT group. Conclusion: Citicoline administered orally at a dose of 500 mg, seems to have a neuroprotective effect. This effect is apparent after a cycle of at least 60 days and tends to moderately decrease at discontinuation of the drug

Renegotiating Responsibilities in Human-Computer Ensembles

This paper proposes discussions for the (re)negotiation of responsibilities in performances that involve a collaboration between human and computer agents. Most of current research is human-hierarchical, leaving the machine the role of a mere tool at performer’s service. In this paper a more balanced distribution of responsibilities between the two agent is proposed. Chimney, a software developed by one of the authors, is proposed as a design probe to reflect on this topic. Chimney allows the composer to control only the musical material of a piece, leaving its evolution to an algorithmic agent whose decisions are unpredictable. This redistribution of responsibilities results in a compositional shift that causes the roles of the composer / performer to overlap. The implications for the experience of the performer operating Chimney are also discussed

Hedysarum coronarium-Based Green Composites Prepared by Compression Molding and Fused Deposition Modeling

In this work, an innovative green composite was produced by adding Hedysarum coronarium (HC) flour to a starch-based biodegradable polymer (Mater-Bi\uae, MB). The flour was obtained by grinding together stems, leaves and flowers and subsequently sieving it, selecting a fraction from 75 \ub5m to 300 \ub5m. Four formulations have been produced by compression molding (CM) and fused deposition modeling (FDM) by adding 5%, 10%, 15% and 20% of HC to MB. The influence of filler content on the processability was tested, and rheological, morphological and mechanical properties of composites were also assessed. Through CM, it was possible to obtain easily homogeneous samples with all filler amounts. Concerning FDM, 5% and 10% HC-filled composites proved also easily printable. Mechanical results showed filler effectively acted as reinforcement: Young\u2019s modulus and tensile strengths of the composites increased from 74.3 MPa to 236 MPa and from 18.6 MPa to 33.4 MPa, respectively, when 20% of HC was added to the pure matrix. FDM samples, moreover, showed higher mechanical properties if compared with CM ones due to rectilinear infill and fibers orientation. In fact, regarding the 10% HC composites, Young\u2019s modulus of the CM and FDM ones displayed a relative increment of 176% and 224%, respectively

Medication-related osteonecrosis of the jaw in a cancer patient receiving lenvatinib

Medication-related osteonecrosis of the jaw (MRONJ) is an adverse drug reaction that affects the mandible and maxilla of patients exposed to bone-targeting agents such as anti-resorptive and anti-angiogenic agents. Several MRONJ cases have been reported after dental extractions in patients under treatment with anti-angiogenic agents, including receptor activator of nuclear factor κB ligand (RANKL) inhibitor, anti-vascular endothelial growth factor (anti-VEGF) monoclonal antibody, mammalian target of rapamycin (mTOR) inhibitors, and tyrosine kinase inhibitors (TKIs). The aim of this article was to describe an original case of lenvatinib-related osteonecrosis of the jaw in a patient affected by thyroid cancer. A 58-year-old man diagnosed with Hurthle cell thyroid cancer, who was undergoing treatment with lenvatinib, developed maxillary osteonecrosis after a dental extraction. No other concomitant local or systemic risk factors for MRONJ were present. With new cancer therapies applied every year, it is important to note this novel case of lenvatinib osteonecrosis of the jaw in a patient undergoing cancer treatment

The Pracademic and Academic in Criminal Justice Education: A Qualitative Analysis

Over the past several years, a few hundred colleagues involved in criminal justice education have participated in panel discussions and roundtables to discuss the trials and issues that have been observed by practitioners turned academics, or “pracademics.” Some complained of having difficulty breaking into academia. A debate has occurred in a number of colleges and universities over the benefit of having faculty with traditional academic credentials versus hiring non-traditional scholars with a blend of educational and practical experience. Similarly, there have been lively discussions over the appropriateness of a J.D. or professional doctorate as opposed to a Ph.D. in criminal justice. This debate started in an article in ACJS Today (2002) and continued in subsequent publications. It is believed that there is importance, benefit and relevance to incorporating practical experience on college and university campuses. In academic program after program, internships, externships, observation, and practicums have become essential in preparing students for the real world

Predictors of Behavioral Competence and Self-Esteem: A Study Assessing Impact in a Basic Public Speaking Course

As evaluation in higher education receives increasing attention, the assessment of the impact of basic oral communication instruction is becoming more important. This study examines the impact of a public speaking course on undergraduates\u27 affective and behavioral competence. Using a pre- and posttest model, assessment was based on administration of the Communication Competency Assessment Instrument and the Rosenberg Self-Esteem Scale at the beginning and end of the course. Communication competence and self-esteem were measured as a function of communication apprehension, gender, age, and ethnicity. Results indicated that the course generally impacted similarly on students regardless of their level of communication apprehension, gender, age or ethnicity

Predictors of Self-Perceptions of Behavioral Competence, Self-Esteem, and Willingness to Communicate: A Study Assessing Impact in a Basic Interpersonal Communication Course

Considering the emergent role of evaluation in higher education, it is important that assessment procedures be developed for all communication courses. Courses such as public speaking already have well established assessment programs while other courses are in need of additional attention. This article describes an assessment program that examines the impact of an interpersonal course on undergraduates\u27 self-perceived behavioral and affective competence. Using a pre- and post-test model, assessment was based on administration of the Communication Behaviors Inventory, the Rosenberg Self-Esteem Scale, and the Willingness to Communicate Scale. These outcomes were measured as a function of gender, age, and ethnicity. Results indicated that the course impacted similarly on students regardless of these predictor variables, with significant improvement being demonstrated for all groups of students. The article provides a description of the interpersonal course and its assessment procedures. The results of analyses of data are presented with a discussion of future directions for assessment in this course

Recent Developments and Formulations for Hydrophobic Modification of Carrageenan Bionanocomposites

Versatility of the anionic algal polysaccharide carrageenan has long been discussed and explored, especially for their affinity towards water molecules. While this feature is advantageous in certain applications such as water remediation, wound healing, etc., the usefulness of this biopolymer is extremely limited when it comes to applications such as food packaging. Scientists around the globe are carrying out research works on venturing diverse methods to integrate hydrophobic nature into these polysaccharides without compromising their other functionalities. Considering these foregoing studies, this review is designed to have an in-depth understanding of diverse methods and techniques adopted for tuning the hydrophobic nature of carrageenan-based bionanocomposites, both via surface alterations or by changes made to their chemical structure and attached functional groups. This review article mainly focuses on how the hydrophobicity of carrageenan bionanocomposites varies as a function of the type and refinement of carrageenan, and with the incorporation of additives including plasticisers, nanofillers, bioactive agents, etc. Incorporation of nanofillers such as polysaccharide-based nanoparticles, nanoclays, bioceramic and mineral based nanoparticles, carbon dots and nanotubes, metal oxide nanoparticles, etc., along with their synergistic effects in hybrid bionanocomposites are also dealt with in this comprehensive review article

Corneal thickness in children with growth hormone deficiency: The effect of GH treatment.

Abstract OBJECTIVE: The eye represents a target site for GH action, although few data are available in patients with GH deficiency (GHD). Our aim was to evaluate central corneal thickness (CCT) and intraocular pressure (IOP) values in GHD children to assess the role played by GHD or GH treatment on these parameters. DESIGN: In 74 prepubertal GHD children (51M, 23F, aged 10.4\ub12.4years) we measured CCT and IOP before and after 12months of treatment. A baseline evaluation was also made in 50 healthy children matched for age, gender and body mass index. The study outcome considered CCT and IOP during treatment and their correlations with biochemical and auxological data. RESULTS: No difference in CCT and IOP between GHD children at baseline and controls was found (all p>0.005). GHD children after 12months of therapy showed greater CCT (564.7\ub113.1\u3bcm) than both baseline values (535.7\ub117\u3bcm; p<0.001) and control subjects (536.2\ub112.5\u3bcm; p<0.001), with a concomitantly higher corrected mean IOP (15.6\ub10.7mmHg; p<0.001) than both baseline (12.5\ub10.8mmHg; p<0.001) and controls (12.3\ub10.5mmHg; p<0.001), without correlation with auxological and biochemical parameters. CONCLUSIONS: 12months of GH treatment in children with GHD, regardless of auxological and biochemical data, affect CCT and IOP. Our findings suggest careful ocular evaluation in these patients to prevent undesirable side effects during the follow-up

Differential expression of proteins in omental and subcutaneous adipose tissue related to sexual stedroids concentrations

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