42 research outputs found
<em>HSD3B</em> and Gene-Gene Interactions in a Pathway-Based Analysis of Genetic Susceptibility to Bladder Cancer
<div><p>Bladder cancer is the 4<sup>th</sup> most common cancer among men in the U.S. We analyzed variant genotypes hypothesized to modify major biological processes involved in bladder carcinogenesis, including hormone regulation, apoptosis, DNA repair, immune surveillance, metabolism, proliferation, and telomere maintenance. Logistic regression was used to assess the relationship between genetic variation affecting these processes and susceptibility in 563 genotyped urothelial cell carcinoma cases and 863 controls enrolled in a case–control study of incident bladder cancer conducted in New Hampshire, U.S. We evaluated gene–gene interactions using Multifactor Dimensionality Reduction (MDR) and Statistical Epistasis Network analysis. The 3′UTR flanking variant form of the hormone regulation gene <em>HSD3B2</em> was associated with increased bladder cancer risk in the New Hampshire population (adjusted OR 1.85 95%CI 1.31–2.62). This finding was successfully replicated in the Texas Bladder Cancer Study with 957 controls, 497 cases (adjusted OR 3.66 95%CI 1.06–12.63). The effect of this prevalent SNP was stronger among males (OR 2.13 95%CI 1.40–3.25) than females (OR 1.56 95%CI 0.83–2.95), (SNP-gender interaction <em>P</em> = 0.048). We also identified a SNP-SNP interaction between T-cell activation related genes <em>GATA3</em> and <em>CD81</em> (interaction <em>P</em> = 0.0003). The fact that bladder cancer incidence is 3–4 times higher in males suggests the involvement of hormone levels. This biologic process-based analysis suggests candidate susceptibility markers and supports the theory that disrupted hormone regulation plays a role in bladder carcinogenesis.</p> </div
HSD3B2 SNP and bladder cancer risk in the New Hampshire population, by gender.
<p>Adjusted for age, gender, smoking.</p
SNP-SNP interactions identified by Statistical Epistasis Network Analysis.
<p>SNP-SNP interactions identified by Statistical Epistasis Network Analysis.</p
HSD3B2 proxy SNP is associated with bladder cancer risk in the Texas population.
<p>Adjusted for age, gender, smoking.</p
New Hampshire study population characteristics.
<p>missing: smoking n = 21, recurrence n = 57.</p
SNP-SNP interactions identified by Multifactor Dimensionality Reduction.
<p>missing GATA3_23 n = 2, CD81_04 n = 39.</p
Development of a cell transducible RhoA inhibitor TAT-C3 transferase and its encapsulation in biocompatible microspheres to promote survival and enhance regeneration of severed neurons
10.1007/s11095-007-9454-6Pharmaceutical Research24122297-230