A Comparative Light Microscopic Study and Clinical Evaluation on Acute Viral Hepatitis Type A, B, and Non-A, Non-B

We studied a total of 55 patients with acute hepatitis type A (7 patients), B (20 patients) and non-A, non-B (28 patients) on light microscopic differences of their liver biopsies and their clinical evaluations. We found that the frequency and degree of some histological features seem to be characteristic to each type of hepatitis. In the liver parenchyma, the degree of necrosis was observed to be more severe in type A and B, extending necrosis was observed in type B and non-A, non-B, and reticuloendothelial reaction was more prominent in type B and non-A, non-B. In the portal area, bile duct lesions were frequently seen in type B and non-A, non-B. Although some predominant findings in each type hepatitis were observed, we could not find any specific differences which separate the three types of hepatitis histologically. Clinically and biochemically acute hepatitis type A showed the high degree of liver dysfunction and more rapid resolution than other types of B and non-A, non-B. On the other hand, acute hepatitis type non-A, non-B showed relatively mild liver dysfunction than other types of A and B but slowly resolved during the convalescent stage and some of them showed progression to chronicity

A Comparative Light Microscopic Study and Clinical Evaluation on Acute Viral Hepatitis Type A, B, and Non-A, Non-B

We studied a total of 55 patients with acute hepatitis type A (7 patients), B (20 patients) and non-A, non-B (28 patients) on light microscopic differences of their liver biopsies and their clinical evaluations. We found that the frequency and degree of some histological features seem to be characteristic to each type of hepatitis. In the liver parenchyma, the degree of necrosis was observed to be more severe in type A and B, extending necrosis was observed in type B and non-A, non-B, and reticuloendothelial reaction was more prominent in type B and non-A, non-B. In the portal area, bile duct lesions were frequently seen in type B and non-A, non-B. Although some predominant findings in each type hepatitis were observed, we could not find any specific differences which separate the three types of hepatitis histologically. Clinically and biochemically acute hepatitis type A showed the high degree of liver dysfunction and more rapid resolution than other types of B and non-A, non-B. On the other hand, acute hepatitis type non-A, non-B showed relatively mild liver dysfunction than other types of A and B but slowly resolved during the convalescent stage and some of them showed progression to chronicity