Genetic and epigenetic regulation of CCR5 transcription

biolog

Chirality Induction in Bioorganometallic Conjugates

Considerable attention has been given to the research field of bioorganometallic chemistry, which is a hybrid chemistry field between biology and organometallic chemistry. The introduction of biomolecules, which have hydrogen bonding sites and chiral centers, into organometallic compounds is a promising strategy to construct chirality-organized bioorganometallic conjugates. This feature paper sketches an outline of induction of helical chirality into bioorganometallic conjugates by the control of a torsional twist of the organometallic moiety. Topics covered included control of the helical chirality of 1,n′-disubstituted ferrocene moieties in ferrocene-dipeptide conjugates, and the chirality induction of the Au(I)–Au(I) axis in the dinuclear organogold(I)-uracil conjugates

The Acidic Amino-Terminal Region of Varicella-Zoster Virus Open Reading Frame 4 Protein Is Required for Transactivation and Can Functionally Replace the Corresponding Region of Herpes Simplex Virus ICP27

AbstractBoth varicella-zoster virus open reading frame 4 (ORF4) protein and its herpes simplex virus type 1 homolog ICP27 have highly acidic amino-terminal regions and cysteine-rich carboxy-terminal regions. To investigate the functional domains of these proteins, mutants were constructed and their transregulatory functions were tested in transient expression assays using two reporter plasmids, pTK-CAT-SV40A and pTK-CAT-synA, containing the same promoter sequences but different mRNA processing signals. ORF4 transactivates both pTK-CAT-SV40A and pTK-CAT-synA, while ICP27 transrepresses pTKCAT-SV40A and transactivates pTK-CAT-synA. Deletion of the ORF4 amino-terminal region abolished most of the transactivating activity for pTK-CAT-synA but retained most of the transactivating activity for pTK-CAT-SV40A. Construction of chimeric ORF4-ICP27 molecules indicated that the ORF4 amino-terminal region was able to replace the corresponding region of ICP27 which is required for both transrepression of pTK-CAT-SV40A and transactivation of pTK-CAT-synA. Similarly, the ICP27 amino-terminal region was able to partially replace the corresponding region of ORF4 which is required for transactivation of pTK-CAT-synA. Thus, while ORF4 and ICP27 have different properties in transient expression assays, the aminoterminal regions of ORF4 and ICP27 are functionally homologous to each other and are important in regulating gene expression

Effectiveness of Health Communication Technology on Compliance Disposition of Covid-19 Guidelines

Recent research has mostly examined the role of health communication technology (HCT) in patient empowerment and in producing patient-focused outcomes. This study examines HCT in a larger context where it is used as a tool to improve public health. The objective is to examine how HCT is used to monitor Covid-19’s spread, and how social factors affect individual assessment of HCT and individual compliance disposition of Covid-19 guidelines. Analyzing data collected from 360 HCT users suggests that the information and system quality of HCT indeed impact users’ assessment of its effectiveness and their compliance disposition. However, such effects are strongly mediated by social factors: Peer influence and government trust can sway an individual’s cognitive judgments of Covid-19 regardless of HCT’s impacts. The findings highlight the importance of social factors in pandemic management and the need to socialize health informatics to make them more effective

Photogenerated-Carrier Collection by Induced Junction and Application to Novel Type of High-Efficiency Si Solar Cell

A novel type of induced junction (IJ) solar cells to achieve a high efficiency without an n⁺ doped layer was proposed. A strong inversion induced by an external bias voltage across an insulating layer yields a very shallow n⁺p junction without impurity doping, and heavy doping effects can be taken away. Performances of the IJ cells were discussed in detail, and a conversion efficiency larger than 20% could be expected. A cell-fabrication process was outlined including formation of a charge-collection barrier by ion implantation and deposition of a gate insulator with a high dielectric constant. A very low sheet resistance could be realized at a low bias voltage, and the power of the photo-generated current source increased with bias voltage