悪性リンパ腫に対するチサゲンレクルユーセル投与後に見られる線溶抑制および相対的凝固亢進状態

京都大学新制・課程博士博士(人間健康科学)甲第24292号人健博第107号新制||人健||8(附属図書館)京都大学大学院医学研究科人間健康科学系専攻(主査)教授 藤井 康友, 教授 岡 昌吾, 教授 滝田 順子学位規則第4条第1項該当Doctor of Human Health SciencesKyoto UniversityDFA

A Step toward the Improvement of English Teaching : A Semantic Approach to -Ment and -Tion

現在の英語教育では、単語の意昧を覚えることの重要性は強調されている一方、より小さな単位である接辞についてはあまり触れられない。しかも、多義語においても、それらを意味の羅列として教える。しかしながら、接辞の意味そしてそれらの意味の体系を教えることは、学習者の語彙習得に大きく貢献できることは間違いない。実際、今回行った実験でも接尾辞についての言語学的説明を与えるほど単語テストの点数が上がった。本論文では、実験の概要から始まり、次にどのような言語学的説明を与えることで、学習者の接尾辞学習が進んだかを説明する。具体的にはまず接尾辞付与の条件が意味にあることを証明した後、認知言語学的手法を用いて接尾辞-mentと-tionの中心義、棲み分けを明らかにする。さらに心理動詞と形容詞を取り上げ、なぜそれらの多くは-tionではなく-mentが付くのかを説明し、そこにも動詞で見たような-mentと-tionの意味的な違いが関連していることを示す。Article信州大学高等教育システムセンター紀要 2: 129-146(2006)departmental bulletin pape

The Incidence and Prognostic Value of Hypochloremia in Critically Ill Patients

Little is known on the clinical effects of chloride on critically ill patients. We conducted this retrospective, observational study in 488 critically ill patients to investigate the incidence of chloride abnormalities, effects of hypochloremia in acid-base disorders, and association between chloride and clinical outcome. The study involved retrieval of arterial blood gas analyses, biochemical and demographical data from electrical records as well as quantitative acid-base analyses. For statistical analysis, the patients were stratified into three groups according to their chloride level (normal range: 98–106 mEq/L). The distribution of chloride levels was hyperchloremia 16.6%, normochloremia 74.6%, and hypochloremia 8.8%. The hypochloremic group was significantly alkalemic (P < 0.0001) and has significantly higher apparent strong ion difference (SIDa) (P < 0.0001) compared to the two other groups. The hypochloremic group had significantly longer stays in the ICU and hospital (P < 0.0001) with higher mortality (P < 0.0001). However, multiple regression analysis showed that chloride was not an independent factor of poorer outcome. In conclusion, the acid-base characteristics of the hypochloremic patients were alkalemia coexisting with higher SIDa. And although it was not an independent prognostic factor, hypochloremia was related to poorer outcome in critically ill settings

What Behaviors Are Important for Successful Weight Maintenance?

Purpose. To examine behavioral factors related to successful weight maintenance. Methods. Subjects were 90 middle-aged participants who attended a weight loss program and were followed for one year. The subjects were classified into either successful weight maintainers (maintained a weight loss of 5% or more from their initial weight for one year) (SWM) or unsuccessful weight maintainers (USWM), and weight control practice, stress, obstacles, support, and self-efficacy during the program and follow-up period were compared. Results. SWM had mean loss of 12% from their initial weight during the program. They showed a greater improvement in their regularity of eating, walked more, and felt less stress regarding their increased physical activity than the USWM. During the follow-up period, significantly more SWM participants had self-efficacy (for measuring weight, practicing dietary objective, and assessing the practice and keeping records), actually kept records and measured weight more than the USWM participants. In contrast, more USWM participants felt stress about measuring weight. Conclusion. In addition to a substantial initial weight loss due to an increased amount of physical activity, having a higher self-efficacy and consistently keeping records of one's activities, as well as regularly weighing themselves, may be important for successful weight maintenance

ニホンゴ ノ ジタタイオウドウシ : エイゴボゴワシャ ニ ヨル ジタタイオウドウシ ノ シュウトク

本稿は日本語学習者の自他対応動詞の習得において、動詞の種類(自動詞と他動詞)がどのように影響しているか調べることを目的とするものである。また、4つの日本語能力グループ(中級I、中級II、上級I、上級II)間の習得の様子も調査した。本研究ではオーストラリア国立大学で日本語を学習している英語母語話者を対象とし、筆記テストおよびフォローアップインタビューの結果を分析した。統計分析にはGeneralised Linear Mixed Model(一般線形混合モデル)(Schall, 1991)が使われた。分析結果により(1)他動詞は自動詞よりも習得しやすい、(2)中級Iと中級IIグループ間のテスト結果に有意差は見られなかった。結果(1)に対する説明として、次の3つが挙げられる。(i)日英語間の語彙的な違い、(ii)文構造の違い、(iii)指示文に現れる自動詞と他動詞の頻度差。一方、結果(2)に対してはU-shaped behavioural development(Kellerman, 1985)の instructional effectというものに起因すると考えられる。This study examined how the acquisition of Japanese intransitive-transitive paired verbs by students of Japanese is affected by verb type (intransitive-transitive). The acquisition of the paired verbs across four levels of Japanese proficiency groups (Intermediate I, Intermediate II, Advanced I and Advanced II) was also explored. The study analysed the performance of native English speaking students of different Japanese proficiency levels enrolled at The Australian National University using a written test and a follow-up interview. A Generalised Linear Mixed Model (Schall, 1991) was used for the statistical analysis. The study found:(1) transitive verbs were easier to acquire than intransitive verbs.(2) there was no significant difference in results between the test scores for Intermediate I and II group in spite of the higher general Japanese ability of members of Intermediate II.Three contributory explanations for finding (1) are put forward: (i) the lexical differences between Japanese and English; (ii) the structural differences of the two languages; and, (iii) the differences in the frequency with which intransitive and transitive verbs occur in the instructions used by language teachers and in language textbooks. The explanation for finding (2), is that it reflects ‘U-shaped behavioural development’ (Kellerman, 1985) which in this case was attributable to an instructional effect

Acute non-heparin-induced thrombocytopenia during hemodiafiltration in a patient with multiple myeloma

This report demonstrates that not only heparin‐induced thrombocytopenia, but also hemodialysis conditions (platelet activation due to hemodiafiltration and heparin underdosing) may markedly reduce the platelet count and cause clotting in the hemodialysis circuit in patients in a hypercoagulable state. The clot prevention effects of bortezomib are therefore of great importance

The Relation of Coffee Consumption to Serum Uric Acid in Japanese Men and Women Aged 49–76 Years

Objective. Few studies have suggested an inverse relation between coffee intake and serum concentrations of uric acid (UA), but none has addressed the relation in men and women separately. We examined the relation between coffee intake and serum UA levels in free-living middle-aged and elderly men and women in Fukuoka, Japan. Methods. Study subjects were derived from the baseline survey of a cohort study on lifestyle-related diseases, and included 11.662 men and women aged 49–76 years; excluded were those with medication for gout and hyperuricemia, use of diuretic drugs, and medical care for cancer or chronic kidney disease. Statistical adjustment was made for body mass index, alcohol use, hypertension, diabetes mellitus, and other factors. Results. There were inverse associations of coffee consumption with serum UA concentrations and hyperuricemia in men regardless of adjustment for covariates. Women showed a statistically significant, but weaker, inverse association between coffee and serum UA levels after allowance for the confounding factors. Conclusion. The findings add to evidence for a protective association between coffee intake and hyperuricemia