Flower Bud Differentiation and Flowering of Tray Grown Strawberry 'Nyoho' as Affected by Plant age and the Duration of Nutrient Starvation

In the forcing production of strawberry Fragaria × ananassa Duch., the use of tray plants grown from cuttings of runner tips is becoming popular with the increase in strawberry production with substrate culture systems, due to their lower cost and ease of plant management compared to conventional pot-grown plants. Effects of the date of runner cutting and the duration of nutrient starvation on flower bud differentiation and flowering of tray grown plants of strawberry 'Nyoho' were investigated. Plants cut on mid or late July and rooted on cell trays performed early and uniform flower bud differentiation and flowering compared to June or August cut plants. When the plants were supplied nutrient solution containing ca. 6 mg-N/plant/week, nutrient starvation from the end of August led to the early and uniform flowering of tray plants, outperforming the earlier or later starvation.イチゴでは，根域容量130mL程度のセルトレイを利用した挿し苗育苗が省力育苗技術として急速に普及している．そこで，‘女峰’を用いて挿し苗時期と施肥中断時期が花芽分化と開花に及ぼす影響について検討した．挿し苗は7月中下旬が適期であり，6月や8月挿し苗区より花芽分化と開花が早く，極端に遅れる株が少なかった．液肥を用いて約6㎎-N/株・週の割合で与えた場合，施肥中断時期は8月末が最も優れ，週間早いと定植前の肥料不足によって極端に開花の遅れる株が増加し，1週間遅れると高窒素による花芽分化抑制が認められた

Residual Set-up Error for Canine Brain Radiation Therapy

When targeting a structure in three-dimensional space, the repositioning accuracy of the patient on the treatment table should be consistent among all radiation treatment sessions. Immobilization devices are used reposition the patients, and imaging systems built into the radiation machine are used to correct the patient’s position prior to treatment. Radiation oncologists usually treat a margin of normal tissue around the tumor called planning target volume (PTV) to account for interfraction (set-up errors) and intrafraction motion (such as motion due to respiration). The size of the PTV margin is an estimate of the targeting accuracy that can be achieved using immobilization devices and image guidance. The PTV margin reported for stereotactic radiation therapy (SRT) and stereotactic radiosurgery (SRS) to treat canine brain tumors ranges from 0-3 millimeters (Kelsey, Gieger, and Nolan 2018; Griffin et al. 2014; Dolera et al. 2017). An ideal margin would be a narrow margin to minimize the chance of toxicity to the normal brain and wide enough to cover the entire tumor target. The size of the PTV margin also depends on the radiation therapy delivery technique and the fractionation scheme (dose of radiation for each treatment session) planned for determined tumor types and locations. Accurate patient set-up and adequate PTV margin selection are required to minimize the chance of radiation side effects to the normal tissue surrounding the tumor region and to maximize tumor control. This is particularly relevant for SRS and SRT treatments, as higher doses of radiation are used to treat cancers compared to conventional radiation protocols

Growth and Yield of Substrate-Cultured Strawberry as Affected by Root Zone Volume and Fertigation Frequency

Effects of root-zone volume and fertigation frequency on 4 cultivars of substrate-grown strawberry (Fragaria×ananassa Duch., ‘Nyoho’, ‘Asukarubi’, ‘Akihime’ and ‘Tochiotome’) were investigated. Fertigation frequency had no significant effect on growth and yield of strawberry even in the minimum root-zone volume of 0.6L/plant. Total yield, mean berry weight, and root dry weight at end of harvest decreased with decrease in volume, but no significant difference was observed in number of harvested berries and subsequent growth of runners and daughter plants. In the yield and root growth, there were large differences between peat bags (2.25L/plant) and bowl-shaped containers (0.6-1.5L/plant), and highly significant non-linear regressions between the two parameters and the root-zone volume. The differences may be caused by factors other than the volume, such as the shape of root-zone and edge of containers or drain property, and so on

テンイソウ デ ホルモン ジュヨウタイ ノ ヘンイ オ ミトメタ ニュウガン ノ 1レイ

A 44 year old woman visited the hospital with complaint of the right breast tumor which she left for two years. She presented with a large mass of８．５cm in diameter with skin invasion, right axillar lymph nodes, multiple liver, and bone metastases. Core needle biopsy of the main tumor revealed an invasive ductal carcinoma（scirrhous carcinoma）with nuclear grade 2 with ER（＋）,PgR（＋）, HER2（－）. The patient was treated with hormone therapy for three and a half year.The extensive mediastinum lymph nodes metastasis and multiple lung metastasis and a new tumor in the right thyroid lobe were appeared. The liver metastasis also increased in size and number.The therapy switched to chemotherapy with paclitaxel. Although the reductive effect was appeared in the breast mass, lung metastasis and liver metastasis, the thyroid and mediastinal lymph node metastases increased in size aggressively. The cytology of needle biopsy specimen from the thyroid tumor was consistent with breast cancer metastasis. Histopathology of the biopsy specimens from the mediastinal lymph node and the liver metastases also consist with breast cancer metastases, but ER and PgR receptor status converted to negative in mediastinal lymph nodes

A case report of secretory carcinoma of the breast in elderly

A 67-year-old woman was seen at the hospital because of a tumor in the area of the right breast. On physical examination, the tumor was elastic hard and movable. A core needlebiopsy revealed malignant findings' invasive ductal carcinoma. Mastectomy for right breast was performed. Pathological diagnosis was secretory carcinoma. The immunoprofile data were negative for ER, PR, and HER2, and were positive for the S-100, EMA, Adipophilin. She has been free from recurrence and metastasis so far. Secretory breast carcinomas are rare tumors, low-grade triple-negative carcinomas. Distant metastases from secretory breast carcinomas and local recurrence are extremely rare. Standard treatment has not been deciderd yet. We report a case of secretory carcinoma of the breast together with some bibliographical comments

Sorption-desorption column tests to evaluate the attenuation layer using soil amended with a stabilising agent

Sorption-desorption column tests using acrylic columns (ϕ 5 cm × h 10 cm) were employed to evaluate the sorption performance of an attenuation layer against geogenic contamination. The attenuation layer material was silica sand amended with 1, 5, or 10% of a stabilising agent. The main component of the agent was magnesium oxide. The sorption behaviour of the materials was determined by a fluoride solution (C₀ = 80 mg/L F-), while the desorption behaviour was determined by distilled water. Breakthroughs (C/C₀ > 0.05) occurred after approximately 1, 20, and 50 PVF for stabilising agent contents of 1, 5, and 10%, respectively. The one-dimensional advection-dispersion equation modelled the breakthrough curves obtained from the tests. The predictions gave unrealistic estimates, especially for the breakthrough point where C/C₀ = 0.05. For the 1% agent content, approximately 20% of the sorbed mass, Ss, was desorbed, but the percentage of desorbed mass, Sd, was much smaller for the higher agent contents. The difference between the sorbed and desorbed masses was defined as the immobilised fraction, Ss - Sd. For the 5% agent content, Ss - Sd = 4.0 mg/g. The results suggest that when silica sand is amended with magnesium oxide as an agent, the mixture can immobilise the fluoride in the attenuation layer

A case of the gastric metastasis from invasive lobular carcinoma of the breast

A 45-year-old woman underwent total mastectomy with axillary lymph node dissection for right breast cancer in 2015. Histopathological examination of the resected specimen showed triple-negative invasive lobular carcinoma and advanced lymph node metastasis. The patient underwent postoperative adjuvant therapy consisting of a dose-dense epirubicin-cyclophosphamide regimen and weekly paclitaxel and radiotherapy. However, multiple bone metastases were detected, 18 months postoperatively. The patient developed upper abdominal discomfort, 21 months postoperatively, and gastroscopy revealed multiple, irregular depressed lesions in the stomach. Histopathological examination of stomach biopsy specimens revealed tumor cells that showed diffuse invasion of the lamina propria of mucous membrane. Immunohistochemical evaluation of biopsy specimens obtained from the stomach and the excised breast tissue showed cells that were immunopositive for CK7 and GCDFP-15 and immunonegative for CK20. The gastric lesion was therefore diagnosed as metastases from invasive lobular carcinoma of the breast. Although the patient received chemotherapy, she died of meningeal carcinomatosis from breast cancer, 7 month after the diagnosis of stomach metastasis. Immunohistochemical evaluation for CK20, which is expressed in gastric cancer and GCDFP-15, which originates from breast tissue, is useful to distinguish between breast cancer metastases and signet ring cell carcinoma of the stomach

A Statistical Study of Gamma-Ray Emitting Solar Flares Observed with Yohkoh

Gamma-ray emitting solar flares observed with Yohkoh were analyzed from a statistical viewpoint. The four-band hard X-ray (15--95 keV) photometric data, taken with the Hard X-ray Telescope onboard Yohkoh, were utilized in combination with the spectro-photometric gamma-ray (0.2--30 MeV) data obtained with the Gamma-Ray Spectrometer. The GOES class was also incorporated. Out of 2788 X-ray flares observed from 1991 October to 2001 December, 178 events with strong hard X-ray emission were selected. Among them, 40 flares were further found to show significant gamma-ray emission. A fractal dimension analysis and multi-band color--color plots of the 40 flares suggest that their soft X-ray to MeV gamma-ray spectral energy distributions involve at least four independent parameters. These are: (1) the overall flare size; (2) the relative intensities of the thermal vs. non-thermal signals; (3) the gamma-ray to hard X-ray intensity ratio; and (4) the hard X-ray spectral slope. These results are examined for possible selection effects. Also, the meanings of the third parameter are briefly considered.Comment: 23 pages, 7 figures, PASJ accepte

Treatment algorithm of ACTH deficiency

Objective : To examine diagnostic performance of corticotropin-releasing hormone (CRH) test combined with baseline dehydroepiandrosterone sulfate (DHEA-S) in patients with a suspect of central adrenal insufficiency. Methods : Patients (n=215) requiring daily or intermittent hydrocortisone replacement, or no replacement were retrospectively checked with their peak cortisol after CRH test and baseline DHEA-S. Results : None of 106 patients with the peak cortisol ≥ 17.5 μg / dL after CRH test required replacement, and all 64 patients with the peak cortisol < 10.0 μg / dL required daily replacement. Among 8 patients with 10.0 μg / dL ≤ the peak cortisol < 17.5 μg / dL and baseline DHEA-S below the reference range, 6 patients required daily replacement and 1 patient was under intermittent replacement. Among 37 patients with 10.0 μg / dL ≤ the peak cortisol < 17.5 μg / dL and baseline DHEA-S within the reference range, 10 and 6 patients were under intermittent and daily replacement, respectively. Conclusions : No patients with the peak cortisol ≥ 17.5 μg / dL required hydrocortisone replacement, and all patients with the peak cortisol below 10.0 μg / dL required daily replacement. Careful clinical evaluation was required to determine requirement for replacement in patients with 10.0 μg / dL ≤ the peak cortisol < 17.5 μg / dL even in combination with baseline DHEA-S

Evaluation of efficacy and safety of lascufloxacin for nursing and healthcare associated pneumonia: single-arm, open-label clinical trial: A study protocol

Background: Lascufloxacin hydrochloride (LSFX) is a quinolone antibiotic that inhibits DNA gyrase and topoisomerase IV of bacteria, it is anticipated to minimize antibiotic resistance in bacteria. It exhibits antibacterial activity against a relatively wide range of bacterial species, including anaerobic bacteria, and its efficacy and safety against community-acquired pneumonia have been shown; however, its efficacy and safety against nursing and healthcare associated pneumonia (NHCAP) have not been verified.Methods/Design: Here, a single-arm, open-label, uncontrolled study was conducted in which LSFX was administered to patients with NHCAP at 24 facilities. The research subjects (77 cases) were orally administered 75 mg of LSFX once a day for 7 days. The primary endpoint was the clinical efficacy at the time of test of cure (TOC) (TOC; 5–10 days after the end of LSFX administration), while the secondary endpoints were the efficacy at the time of end of treatment, early clinical efficacy, microbiological efficacy at the time of TOC and end of treatment, and safety evaluation of LSFX.Discussion: NHCAP is a common pneumonia in clinical settings and a notable pneumonia whose mortality is high compared to community-acquired pneumonia. The present study showed the efficacy and safety of LSFX against NHCAP, which could lead to a larger number of therapeutic options for NHCAP