Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Methodology to develop the special safeguard plan of the Bambuco Festival of Neiva

Se plantea la elaboración de la "Metodología para desarrollar el plan especial de salvaguarda del Festival Folclórico del Bambuco de Neiva", convirtiendolo en un valioso instrumento que permitirá proteger y salvaguardar, desde la experiencia y participación ciudadana, los procesos y expresiones creativas, tradicionales y culturales dentro de un contexto urbano, digital, cultural, tradicional y económico. Teniendo en cuenta como referentes la más importantes celebraciones patrimoniales a nivel nacional. En esta medida, es importante reconocer la importancia de establecer el Proyecto Metodología para desarrollar el plan especial de salvaguarda del Festival Folclórico del Bambuco de Neiva, como un instrumento de planeación, dirección, organización y gestión, mediante el cual se disponen acciones, actividades, mecanismos de consulta y estrategias pedagógicas, logísticas y participativas para la construcción del PES. Del mismo modo, sentar los demás lineamientos orientados a garantizar la salvaguarda dentro de un contexto urbano, digital, cultural, tradicional y económico del Patrimonio Cultural Inmaterial del municipio de Neiva.The elaboration of the "Methodology for the development of the special safeguard plan of the Neiva Bambuco Folkloric Festival", making it a valuable instrument that will allow to protect and safeguard, from the experience and citizen participation, the creative, traditional and cultural processes and expressions within an urban, digital, cultural, traditional and economic context. Taking into account the most important national heritage celebrations as references. In this measure, it is important to recognize the importance of establishing the Methodology Project to develop the special safeguard plan of the Folkloric Festival of the Bambuco of Neiva, as an instrument of planning, direction, organization and management, through which actions, activities, consultation mechanisms and pedagogical, logistical and participatory strategies for the construction of the PES. In the same way, establish the other guidelines aimed at guaranteeing the safeguarding within an urban, digital, cultural, traditional and economic context of the Intangible Cultural Heritage of the municipality of Neiva