Notes on the Chemotherapy of Hexarnitiasis

A method for controlled evaluation of drugs against Hexamita meleagridis in turkeys is presented. Experiments evaluating selected drugs and reevaluating all compounds and antibiotics previously reported to be efficacious against this species are described. Most of these compounds were tested against two separate isolates of this parasite, one from Indiana (1950) and the other from Wisconsin (1959). All preparations found effective against one isolate showed similar efficacy against the other. Conversely, preparations ineffective against one isolate were also ineffective against the other. Among the compounds showing efficacy were several antibiotics and dibutyl tin salts. Dibutyl tin dilaurate was found to have suitable efficacy at non-toxic dosage levels