Mathematical modeling of laser lipolysis

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Cartilage reshaping for protruding ears: a prospective long term follow-up of 32 procedures

Correction of prominent ears is a common plastic surgical procedure. We introduced a new non-invasive laser-assisted cartilage reshaping (LACR) technique as an alternative to invasive surgical otoplasty

1.9 µm diode laser assisted vascular microanastomoses: Experience in 40 clinical procedures

Since the initial work of Jacobson and Suarez in 1960, microsurgery has evolved greatly. In 2009, we reported our clinical experience with 1.9 µm diode laser-assisted vascular microanastomoses (LAMA) for free flap reconstruction. In this report, the ongoing study is now expanded to include 11 additional procedures which were analyzed prospectively with a focus on the duration of the LAMA technique

Focal Laser Ablation of Prostate Cancer: Numerical Simulation of Temperature and Damage Distribution

<p>Abstract</p> <p>Background</p> <p>The use of minimally invasive ablative techniques in the management of patients with low grade and localized prostate tumours could represent a treatment option between active surveillance and radical therapy. Focal laser ablation (FLA) could be one of these treatment modalities. Dosimetry planning and conformation of the treated area to the tumor remain major issues, especially when, several fibers are required. An effective method to perform pre-treatment planning of this therapy is computer simulation. In this study we present an <it>in vivo </it>validation of a mathematical model.</p> <p>Methods</p> <p>The simulation model is based on finite elements method (FEM) to solve the bio-heat and the thermal damage equations. Laser irradiation was performed with a 980 nm laser diode system (5 W, 75 s). Light was transmitted using a cylindrical diffusing fiber inserted inside a preclinical animal prostate cancer model induced in Copenhagen rats. Non-enhanced T2-weighted and dynamic gadolinium-enhanced T1-weighted MR imaging examinations were performed at baseline and 48 hours after the procedure. The model was validated by comparing the simulated necrosis volume to the results obtained <it>in vivo </it>on (MRI) and by histological analysis. 3 iso-damage temperatures were considered 43° C, 45° C and 50° C.</p> <p>Results</p> <p>The mean volume of the tissue necrosis, estimated from the histological analyses was 0.974 ± 0.059 cc and 0.98 ± 0.052 cc on the 48 h MR images. For the simulation model, volumes were: 1.38 cc when T = 43° C, 1.1 cc for T = 45°C and 0.99 cc when T = 50 C°.</p> <p>Conclusions</p> <p>In this study, a clear correlation was established between simulation and <it>in vivo </it>experiments of FLA for prostate cancer.</p> <p>Simulation is a promising planning technique for this therapy. It needs further more evaluation to allow to FLA to become a widely applied surgical method.</p

PHOS-ISTOS: A new flexible and homogeneous device for photodynamic treatment of actinic keratosis, first clinical results

International audienceThe PHOS-ISTOS device (resulting from the European project " CIP project 621103 PHOSISTOS ") based on light emitting fabric is proposed for the treatment of actinic keratosis. Actinic kerato-sis is common pre-cancerous skin lesions, which mainly affect the elderly population. Induced by sun damages, these lesions are usually present on the scalp, shoulders or arms of the patients and thus are easily reachable by light, making PDT one of the first line treatment [1]. Optical fibers are knitted to build a flexible structure that produces homogeneous light. The fabrics are embedded within an adjustable plastic helmet and illuminated by a fractionated LASER source. The low delivered irradiance (4 mW/cm 2) and the shorter photosensitizer application time ensure a significant pain reduction , compared to discomfort levels usually experienced by patients during a conventional PDT. The proposed device delivers a total light dose of 12 J/cm 2 , instead of 37 J/cm 2 which efficiency is being assessed in a bi-centric clinical trial. The first results of the clinical test (assessment of pain, patient's comfort and PDT action of the device) will be presented

A new flexible and homogeneous device for photodynamic treatment of actinic keratosis

International audienc

980-nm laser lipolysis (LAL): About 674 procedures in 359 patients

Since the first studies by Apfelberg in 1994, laser lipolysis (LAL) has been on the rise. Laser lipolysis leads to reduced operator fatigue, excellent patient tolerance, quick recovery time, as well as the additional benefit of dermal tightening. This article reports a 5-year experience of LAL and underlines the potential evolutions of the technique

Laser-induced primary and secondary hemostasis dynamics and mechanisms in relation to selective photothermolysis of port wine stains

Superficial vascular anomalies such as port wine stains are commonly treated by selective photothermolysis (SP). The endovascular laser-tissue interactions underlying SP are governed by a photothermal response (thermocoagulation of blood) and a hemodynamic response (thrombosis). Currently it is not known whether the hemodynamic response encompasses both primary and secondary hemostasis, which platelet receptors are involved, and what the SP-induced thrombosis kinetics are in low-flow venules. To (1) define the role and kinetics of primary and secondary hemostasis in laser-induced thrombus formation and (2) determine which key platelet surface receptors are involved in the hemodynamic response. 532-nm laser-irradiated hamster dorsal skin fold venules were studied by intravital fluorescence microscopy following fluorescent labeling of platelets with 5(6)-carboxyfluorescein. Heparin and fluorescently labeled anti-glycoprotein Ib-α (GPIbα) and anti-P-selectin antibodies were administered to investigate the role of coagulation and platelet receptors, respectively. Lesional sizes were quantified by software. Laser irradiation consistently produced sub-occlusive thermal coagula. Thrombosis was triggered in all irradiated venules in a thermal coagulum-independent manner and peaked at 6.25min post-irradiation. Heparin decreased the maximum thrombus size and caused thrombosis to reach a maximum at 1.25min. Immunoblocking of GPIbα abated the extent of thrombosis, whereas immunoblocking of P-selectin had no effect. The hemodynamic response ensues the photothermal response in a thermal coagulum-independent manner and involves primary and secondary hemostasis. Primary hemostasis is mediated by constitutively expressed GPIbα but not by activation-dependent P-selecti