Children’s Selective Trust Based on Previous Lying Behaviors

This study examined children’s nuanced understanding of prosocial liars and self-serving liars across the following three areas: children’s willingness to learn information from liars, their judgments of liars through their friend preferences, and their visual attention to liars. As children develop theory of mind skills, they learn they can manipulate other’s knowledge states by telling lies. They also evaluate lying based on whether the liar has self-serving or prosocial intentions, with the former judged more negatively and the latter judged more positively. Based on research findings indicating that children demonstrate selective trust in informants based on their previous accuracy or reliability, the current study aimed to discern whether children (ages 4-11 years old) base their willingness to learn novel information on their evaluations of deceptive informants with sensitivity to the informants’ intentions. Results suggest that as children age and increase in moral theory of mind, they increasingly trust information from a prosocial lying informant compared to a neutral informant, and appear to trust information from a self-serving lying informant marginally less than a neutral informant. Further, regardless of intentions of the lying informant, children tend to avoid choosing the lying informant as a friend. Some differences in visual attention are also discussed. Overall, this research indicates that children may have a more nuanced understanding of the intentions of deceptive informants that becomes more pronounced with age, yet children still prefer to have friends who do not lie

The physics of Galaxy Evolution with SPICA observations

The evolution of galaxies at Cosmic Noon (redshift 1<z<3) passed through a dust-obscured phase, during which most stars formed and black holes in galactic nuclei started to shine, which cannot be seen in the optical and UV, but it needs rest frame mid-to-far IR spectroscopy to be unveiled. At these frequencies, dust extinction is minimal and a variety of atomic and molecular transitions, tracing most astrophysical domains, occur. The future IR space telescope mission, SPICA, currently under evaluation for the 5th Medium Size ESA Cosmic Vision Mission, fully redesigned with its 2.5 m mirror cooled down to T < 8K will perform such observations. SPICA will provide for the first time a 3-dimensional spectroscopic view of the hidden side of star formation and black hole accretion in all environments, from voids to cluster cores over 90% of cosmic time. Here we outline what SPICA will do in galaxy evolution studies.Comment: Contributed talk at the IAU Symp 359 Galaxy Evolution and Feedback Across Different Environments, 2020 March 2-6, Bento Concalves, Brazil. arXiv admin note: text overlap with arXiv:1911.1218

Recent Applications of Melanin-like Nanoparticles as Antioxidant Agents

Nanosized antioxidants are highly advantageous in terms of versatility and pharmacokinetics, with respect to conventional molecular ones. Melanin-like materials, artificial species inspired by natural melanin, combine recognized antioxidant (AOX) activity with a unique versatility of preparation and modification. Due to this versatility and documented biocompatibility, artificial melanin has been incorporated into a variety of nanoparticles (NP) in order to give new platforms for nanomedicine with enhanced AOX activity. In this review article, we first discuss the chemical mechanisms behind the AOX activity of materials in the context of the inhibition of the radical chain reaction responsible for the peroxidation of biomolecules. We also focus briefly on the AOX properties of melanin-like NP, considering the effect of parameters such as size, preparation methods and surface functionalization on them. Then, we consider the most recent and relevant applications of AOX melanin-like NPs that are able to counteract ferroptosis and be involved in the treatment of important diseases that affect, e.g., the cardiovascular and nervous systems, as well as the kidneys, liver and articulations. A specific section will be dedicated to cancer treatment, since the role of melanin in this context is still very debated. Finally, we propose future strategies in AOX development for a better chemical understanding of melanin-like materials. In particular, the composition and structure of these materials are still debated, and they present a high level of variability. Thus, a better understanding of the mechanism behind the interaction of melanin-like nanostructures with different radicals and highly reactive species would be highly advantageous for the design of more effective and specific AOX nano-agents