In Vitro Screening Test Using Leishmania Promastigotes Stably Expressing mCherry Protein

Transgenic Leishmania major and Leishmania donovani axenic promastigotes constitutively expressing mCherry were used for in vitro antileishmanial drug screening. This method requires minimal sample manipulation and can be easily adapted to automatic drug tests, allowing primary high-throughput screenings without the need for expensive and sophisticated instrumentsFil: Vacchina, Paola. University Of Notre Dame-Indiana; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Miguel A. Morales. University Of Notre Dame-Indiana; Estados Unido

Harnessing synthetic gauge fields for maximally entangled state generation

We study the generation of entanglement between two species of neutral cold atoms living on an optical ring lattice, where each group of particles can be described by a $d$-dimensional Hilbert space (qu$d$it). Synthetic magnetic fields are exploited to create an entangled state between the pair of qu$d$its. Maximally entangled eigenstates are found for well defined values of the Aharonov-Bohm phase, which are zero energy eigenstates of both the kinetic and interacting parts of the Bose-Hubbard Hamiltonian, making them quite exceptional and robust against certain non-perturbative fluctuations of the Hamiltonian. We propose a protocol to reach the maximally entangled state (MES) by starting from an initially prepared ground state. Also, an indirect method to detect the MES by measuring the current of the particles is proposed.Comment: 10 pages, 3 figure

Equation of state of metallic hydrogen from Coupled Electron-Ion Monte Carlo simulations

We present a study of hydrogen at pressures higher than molecular dissociation using the Coupled Electron-Ion Monte Carlo method. These calculations use the accurate Reptation Quantum Monte Carlo method to estimate the electronic energy and pressure while doing a Monte Carlo simulation of the protons. In addition to presenting simulation results for the equation of state over a large region of phase space, we report the free energy obtained by thermodynamic integration. We find very good agreement with DFT calculations for pressures beyond 600 GPa and densities above $\rho=1.4 g/cm^3$. Both thermodynamic as well as structural properties are accurately reproduced by DFT calculations. This agreement gives a strong support to the different approximations employed in DFT, specifically the approximate exchange-correlation potential and the use of pseudopotentials for the range of densities considered. We find disagreement with chemical models, which suggests a reinvestigation of planetary models, previously constructed using the Saumon-Chabrier-Van Horn equations of state.Comment: 9 pages, 7 figure