34 research outputs found
Sustaining control : lessons from the Lubombo spatial development initiative in southern Africa
BACKGROUND : The Lubombo Spatial Development Initiative (LSDI) was a tri-country project between South Africa,
Swaziland and Mozambique with the aim of accelerating socio-economic development in the region. The malaria
component of the project was introduced to decrease the transmission of malaria in the region. This goal was met
but with termination of this project resulted in an upsurge of malaria cases in the sub-region mainly as a result of
migration from high transmission areas to low transmission ones. The movement of people across borders in southern
Africa remains a challenge in sustaining malaria control and elimination.
METHODS : Malaria case data for Swaziland and South Africa were obtained from their respective national Malaria
Information Systems. Data for Mozambique was obtained from the Mozambican Ministry of Health. Data obtained
during the course of the LSDI project was compared to the case data post the termination of the LSDI.
RESULTS : The 12-year period of the LSDI showed a substantial decrease in disease burden amongst the three countries
involved when compared to the baseline year of 2000. The decrease in malaria cases was 99 % in South Africa
and 98 % in Swaziland. Malaria prevalence in Mozambique decreased by 85 % over the same period. However, after
the LSDI ended, between 2012 and 2014, there was an upward trend in case data that was counter to the goal of
elimination.
CONCLUSION : South Africa and Swaziland benefitted from the LSDI and were able to sustain malaria control and progress
to the stage of elimination. Mozambique could not sustain the gains made during the LSDI and case numbers
increased. Technical and financial resources are key challenges for malaria control and elimination interventions.Data used in this study are available from the Ministries of Health in South
Africa, Swaziland and Mozambique.No direct funding was received for this study however the original LSDI study
was made possible by funds received from the Global Fund to fight AIDS, TB
and Malariahttp://www.malariajournal.comam2016School of Health Systems and Public Health (SHSPH
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Malaria Control in South Africa 2000–2010: Beyond MDG6
Background: Malaria is one of the key targets within Goal 6 of the Millennium Development Goals (MDGs), whereby the disease needs to be halted and reversed by the year 2015. Several other international targets have been set, however the MDGs are universally accepted, hence it is the focus of this manuscript. Methods: An assessment was undertaken to determine the progress South Africa has made against the malaria target of MDG Goal 6. Data were analyzed for the period 2000 until 2010 and verified after municipal boundary changes in some of South Africa’s districts and subsequent to verifying actual residence of malaria positive cases. Results: South Africa has made significant progress in controlling malaria transmission over the past decade; malaria cases declined by 89.41% (63663 in 2000 vs 6741 in 2010) and deaths decreased by 85.4% (453 vs 66) in the year 2000 compared to the year 2010. Coupled with this, malaria cases among children under five years of age have also declined by 93% (6791 in 2000 vs 451 in 2010). This has resulted in South Africa achieving and exceeding the malaria target of the MDGs. A series of interventions have attributed to this decrease, these include: drug policy change from monotherapy to artemisinin combination therapy, insecticide change from pyrethroids back to DDT; cross border collaboration (South Africa with Mozambique and Swaziland through the Lubombo Spatial Development Initiative– LSDI) and financial investment in malaria control. The KwaZulu-Natal Province has seen the largest reduction in malaria cases and deaths (99.1% cases- 41786 vs 380; and 98.5% deaths 340 vs 5), when comparing the year 2000 with 2010. The Limpopo Province recorded the lowest reduction in malaria cases compared to the other malaria endemic provinces (56.1% reduction- 9487 vs 4174; when comparing 2000 to 2010). Conclusions: South Africa is well positioned to move beyond the malaria target of the MDGs and progress towards elimination. However, in addition to its existing interventions, the country will need to sustain its financing for malaria control and support programmed reorientation towards elimination and scale up active surveillance coupled with treatment at the community level. Moreover cross-border malaria collaboration needs to be sustained and scaled up to prevent the re-introduction of malaria into the country
An exploratory study of factors that affect the performance and usage of rapid diagnostic tests for malaria in the Limpopo Province, South Africa
<p>Abstract</p> <p>Background</p> <p>Malaria rapid diagnostic tests (RDTs) are relatively simple to perform and provide results quickly for making treatment decisions. However, the accuracy and application of RDT results depends on several factors such as quality of the RDT, storage, transport and end user performance. A cross sectional survey to explore factors that affect the performance and use of RDTs was conducted in the primary care facilities in South Africa.</p> <p>Methods</p> <p>This study was conducted in three malaria risk sub-districts of the Limpopo Province, in South Africa. Twenty nurses were randomly selected from 17 primary health care facilities, three nurses from hospitals serving the study area and 10 other key informants, representing the managers of the malaria control programmes, routine and research laboratories, were interviewed, using semi-structured questionnaires.</p> <p>Results</p> <p>There was a high degree of efficiency in ordering and distribution of RDTs, however only 13/20 (65%) of the health facilities had appropriate air-conditioning and monitoring of room temperatures. Sixty percent (12/20) of the nurses did not receive any external training on conducting and interpreting RDT. Fifty percent of nurses (10/20) reported RDT stock-outs. Only 3/20 nurses mentioned that they periodically checked quality of RDT. Fifteen percent of nurses reported giving antimalarial drugs even if the RDT was negative.</p> <p>Conclusion</p> <p>Storage, quality assurance, end user training and use of RDT results for clinical decision making in primary care facilities in South Africa need to be improved. Further studies of the factors influencing the quality control of RDTs, their performance of RDTs and the ways to improve their use of RDTs are needed.</p
Case management of malaria : treatment and chemoprophylaxis
Malaria case management is a vital component of programmatic strategies for malaria control and elimination. Malaria case management encompasses prompt and effective treatment to minimise morbidity and mortality, reduce transmission and prevent the emergence and spread of antimalarial drug resistance. Malaria is an acute illness that may progress rapidly to severe disease and death, especially in non-immune populations, if not diagnosed early and promptly treated with effective drugs. In this article, the focus is on malaria case management, addressing treatment, monitoring for parasite drug resistance, and the impact of drug resistance on treatment policies; it concludes with chemoprophylaxis and treatment strategies for malaria elimination in South Africa.http://www.samj.org.zaam2013ay201
Implementing malaria control in South Africa, Eswatini and southern Mozambique during the COVID-19 pandemic
The COVID-19 pandemic has strained healthcare delivery systems in a number of southern African countries. Despite this, it is imperative
that malaria control and elimination activities continue, especially to reduce as far as possible the number and rate of hospitalisations
caused by malaria. The implementation of enhanced malaria control/elimination activities in the context of COVID-19 requires measures
to protect healthcare workers and the communities they serve. The aim of this review is therefore to present innovative ideas for the
timely implementation of malaria control without increasing the risk of COVID-19 to healthcare workers and communities. Specific
recommendations for parasite and vector surveillance, diagnosis, case management, mosquito vector control and community outreach and
sensitisation are given.http://www.samj.org.zaam2021School of Health Systems and Public Health (SHSPH)Veterinary Tropical Disease
Reviewing South Africa’s malaria elimination strategy (2012–2018) : progress, challenges and priorities
BACKGROUND : With a sustained national malaria incidence of fewer than one case per 1000 population at risk, in 2012
South Africa officially transitioned from controlling malaria to the ambitious goal of eliminating malaria within its borders
by 2018. This review assesses the progress made in the 3 years since programme re-orientation while highlighting
challenges and suggesting priorities for moving the malaria programme towards elimination.
METHODS : National malaria case data and annual spray coverage data from 2010 until 2014 were assessed for trends.
Information on surveillance, monitoring and evaluation systems, human and infrastructure needs and community
malaria knowledge was sourced from the national programme mid-term review.
RESULTS : Malaria cases increased markedly from 6811 in 2013 to 11,711 in 2014, with Mpumalanga and Limpopo
provinces most affected. Enhanced local transmission appeared to drive malaria transmission in Limpopo Province,
while imported malaria cases accounted for the majority of cases reported in Mpumalanga Province. Despite these
increases only Vhembe and Mopani districts in Limpopo Province reported malaria incidences more than one case
per 1000 population at risk by 2014. Over the review period annual spray coverage did not reach the recommended
target of 90 % coverage, with information gaps identified in parasite prevalence, artemether-lumefantrine therapeutic
utilization, asymptomatic/sub-patent carriage, drug efficacy, vector distribution and insecticide resistance.
CONCLUSIONS : Although South Africa has made steady progress since adopting an elimination agenda, a number
of challenges have been identified. The heterogeneity of malaria transmission suggests interventions in Vhembe
and Mopani districts should focus on control, while in KwaZulu-Natal Province eliminating transmission foci should
be prioritized. Cross-border initiatives with neighbouring countries should be established/strengthened as a matter
of urgency since malaria importation poses a real threat to the country’s elimination efforts. It is also critical that
provincial programmes are adequately resourced to effectively conduct the necessary targeted elimination activities,
informed by current vector/parasite distribution and resistance data. More sensitive methods to detect sub-patent
infections, primaquine as a transmission-blocking drug, and alternative vector control methods need to be investigated.
Knowledge gaps among malaria health workers and affected communities should be identified and addressed.A South African Medical Research Council Malaria Collaborating Centre Research
Grant to JR, JF, BB.http://www.malariajournal.comam2016School of Health Systems and Public Health (SHSPH
Re-defining the extent of malaria transmission in South Africa : implications for chemoprophylaxis
BACKGROUND. Malaria case numbers reported in South Africa have reduced considerably over the last decade, necessitating a revision of the
national risk map to guide malaria prevention, including the use of chemoprophylaxis.
OBJECTIVES. To update the national malaria risk map based on recent case data and to consider the implications of the new transmission
profile for guiding prophylaxis.
METHODS. The geographical distribution of confirmed malaria cases detected both passively and actively over the last six malaria seasons was used to redefine the geographical distribution and intensity of malaria transmission in the country.
RESULTS. The national risk map was revised to reflect zones of transmission reduced both in their extent and their intensity. Most notably, the area of risk has been reduced in the north-western parts of Limpopo Province and is limited to the extreme northern reaches of KwaZulu-
Natal Province. Areas previously considered to be of high risk are now regarded to be of moderate risk.
CONCLUSION. Chemoprophylaxis is now only recommended from September to May in the north-eastern areas of Limpopo and Mpumalanga Provinces. The recommended options for chemoprophylaxis have not changed from mefloquine, doxycycline or atovaquone-proguanil.http://www.samj.org.zaam2013ay201
Towards malaria elimination in the MOSASWA (Mozambique, South Africa and Swaziland) region
Effectiveness and cost-effectiveness of reactive, targeted indoor residual spraying for malaria control in low-transmission settings: a cluster-randomised, non-inferiority trial in South Africa.
BACKGROUND: Increasing insecticide costs and constrained malaria budgets could make universal vector control strategies, such as indoor residual spraying (IRS), unsustainable in low-transmission settings. We investigated the effectiveness and cost-effectiveness of a reactive, targeted IRS strategy. METHODS: This cluster-randomised, open-label, non-inferiority trial compared reactive, targeted IRS with standard IRS practice in northeastern South Africa over two malaria seasons (2015-17). In standard IRS clusters, programme managers conducted annual mass spray campaigns prioritising areas using historical data, expert opinion, and other factors. In targeted IRS clusters, only houses of index cases (identified through passive surveillance) and their immediate neighbours were sprayed. The non-inferiority margin was 1 case per 1000 person-years. Health service costs of real-world implementation were modelled from primary and secondary data. Incremental costs per disability-adjusted life-year (DALY) were estimated and deterministic and probabilistic sensitivity analyses conducted. This study is registered with ClinicalTrials.gov, NCT02556242. FINDINGS: Malaria incidence was 0·95 per 1000 person-years (95% CI 0·58 to 1·32) in the standard IRS group and 1·05 per 1000 person-years (0·72 to 1·38) in the targeted IRS group, corresponding to a rate difference of 0·10 per 1000 person-years (-0·38 to 0·59), demonstrating non-inferiority for targeted IRS (p<0·0001). Per additional DALY incurred, targeted IRS saved US2637 to $3557 per DALY averted). Depending on the threshold used, targeted IRS would remain cost-effective at incidences of less than 2·0-2·7 per 1000 person-years. Findings were robust to plausible variation in other parameters. INTERPRETATION: Targeted IRS was non-inferior, safe, less costly, and cost-effective compared with standard IRS in this very-low-transmission setting. Saved resources could be reallocated to other malaria control and elimination activities. FUNDING: Joint Global Health Trials