1 research outputs found
Microwave-Based Reaction Screening: Tandem Retro-Diels–Alder/Diels–Alder Cycloadditions of <i>o</i>-Quinol Dimers
We have accomplished a parallel screen of cycloaddition
partners
for <i>o</i>-quinols utilizing a plate-based microwave system.
Microwave irradiation improves the efficiency of retro-Diels–Alder/Diels–Alder
cascades of <i>o-</i>quinol dimers which generally proceed
in a diastereoselective fashion. Computational studies indicate that
asynchronous transition states are favored in Diels–Alder cycloadditions
of <i>o</i>-quinols. Subsequent biological evaluation of
a collection of cycloadducts has identified an inhibitor of activator
protein-1 (AP-1), an oncogenic transcription factor