Tricritical gravity waves in the four-dimensional generalized massive gravity

We construct a generalized massive gravity by combining quadratic curvature gravity with the Chern-Simons term in four dimensions. This may be a candidate for the parity-odd tricritical gravity theory. Considering the AdS$_4$ vacuum solution, we derive the linearized Einstein equation, which is not similar to that of the three dimensional (3D) generalized massive gravity. When a perturbed metric tensor is chosen to be the Kerr-Schild form, the linearized equation reduces to a single massive scalar equation. At the tricritical points where two masses are equal to -1 and 2, we obtain a log-square wave solution to the massive scalar equation. This is compared to the 3D tricritical generalized massive gravity whose dual is a rank-3 logarithmic conformal field theory.Comment: 17 pages, 1 figure, version to appear in EPJ

Effects of oxygen-reducing atmosphere annealing on LaMnO3_3 epitaxial thin films

We investigated the effects of annealing on LaMnO$_3$ epitaxial thin films grown by pulsed laser deposition and propose an efficient method of characterizing their stoichiometry. Structural, magnetic, and optical properties coherently indicate non-stoichiometric ferromagnetic and semiconducting phases for as-grown LaMnO$_3$ films. By annealing in an oxygen-reducing atmosphere, we recovered the antiferromagnetic and insulating phases of bulk-like stoichiometric LaMnO$_3$. We show that non-destructive optical spectroscopy at room temperature is one of the most convenient tools for identifying the phases of LaMnO$_3$ films. Our results serve as a prerequisite in studying LaMnO$_3$ based heterostructures grown by pulsed laser deposition.Comment: 10 pages including 3 figures, accepted in J. Phys. D: Appl. Phy

A Complete Classification of Higher Derivative Gravity in 3D and Criticality in 4D

We study the condition that the theory is unitary and stable in three-dimensional gravity with most general quadratic curvature, Lorentz-Chern-Simons and cosmological terms. We provide the complete classification of the unitary theories around flat Minkowski and (anti-)de Sitter spacetimes. The analysis is performed by examining the quadratic fluctuations around these classical vacua. We also discuss how to understand critical condition for four-dimensional theories at the Lagrangian level.Comment: 20 pages, v2: minor corrections, refs. added, v3: logic modified, v4: typos correcte

Noncritical Einstein-Weyl Gravity and the AdS/CFT Correspondence

We explore four-dimensional Einstein-Weyl gravity and supergravity on anti-de Sitter spacetime. For a specific range of the coupling with appropriate boundary conditions, we show the effective equivalence of the theory with Einstein gravity and AdS supergravity at the quadratic Lagrangian level. Furthermore we show that these equivalences can be promoted to the full nonlinear level. We also show that the similar behavior holds for the generalized Gibbons-Hawking terms. From this we find that the correlation functions in the dual conformal field theory of Einstein-Weyl gravity and supergravity can be readily read off from corresponding ones from Einstein gravity and AdS supergravity. We also give comments on some issues in critical gravity and supergravity as well as conformal gravity and supergravity.Comment: 20 pages, 1 figure: v2, references and footnote added, typos correcte

Genetic Drivers of Heterogeneity in Type 2 Diabetes Pathophysiology

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P \u3c 5 × 10-8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores5 in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P &lt; 5 × 10-8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores5 in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.</p