80 research outputs found
Tricritical gravity waves in the four-dimensional generalized massive gravity
We construct a generalized massive gravity by combining quadratic curvature
gravity with the Chern-Simons term in four dimensions. This may be a candidate
for the parity-odd tricritical gravity theory. Considering the AdS vacuum
solution, we derive the linearized Einstein equation, which is not similar to
that of the three dimensional (3D) generalized massive gravity. When a
perturbed metric tensor is chosen to be the Kerr-Schild form, the linearized
equation reduces to a single massive scalar equation. At the tricritical points
where two masses are equal to -1 and 2, we obtain a log-square wave solution to
the massive scalar equation. This is compared to the 3D tricritical generalized
massive gravity whose dual is a rank-3 logarithmic conformal field theory.Comment: 17 pages, 1 figure, version to appear in EPJ
Effects of oxygen-reducing atmosphere annealing on LaMnO epitaxial thin films
We investigated the effects of annealing on LaMnO epitaxial thin films
grown by pulsed laser deposition and propose an efficient method of
characterizing their stoichiometry. Structural, magnetic, and optical
properties coherently indicate non-stoichiometric ferromagnetic and
semiconducting phases for as-grown LaMnO films. By annealing in an
oxygen-reducing atmosphere, we recovered the antiferromagnetic and insulating
phases of bulk-like stoichiometric LaMnO. We show that non-destructive
optical spectroscopy at room temperature is one of the most convenient tools
for identifying the phases of LaMnO films. Our results serve as a
prerequisite in studying LaMnO based heterostructures grown by pulsed laser
deposition.Comment: 10 pages including 3 figures, accepted in J. Phys. D: Appl. Phy
A Complete Classification of Higher Derivative Gravity in 3D and Criticality in 4D
We study the condition that the theory is unitary and stable in
three-dimensional gravity with most general quadratic curvature,
Lorentz-Chern-Simons and cosmological terms. We provide the complete
classification of the unitary theories around flat Minkowski and (anti-)de
Sitter spacetimes. The analysis is performed by examining the quadratic
fluctuations around these classical vacua. We also discuss how to understand
critical condition for four-dimensional theories at the Lagrangian level.Comment: 20 pages, v2: minor corrections, refs. added, v3: logic modified, v4:
typos correcte
Noncritical Einstein-Weyl Gravity and the AdS/CFT Correspondence
We explore four-dimensional Einstein-Weyl gravity and supergravity on anti-de
Sitter spacetime. For a specific range of the coupling with appropriate
boundary conditions, we show the effective equivalence of the theory with
Einstein gravity and AdS supergravity at the quadratic Lagrangian level.
Furthermore we show that these equivalences can be promoted to the full
nonlinear level. We also show that the similar behavior holds for the
generalized Gibbons-Hawking terms. From this we find that the correlation
functions in the dual conformal field theory of Einstein-Weyl gravity and
supergravity can be readily read off from corresponding ones from Einstein
gravity and AdS supergravity. We also give comments on some issues in critical
gravity and supergravity as well as conformal gravity and supergravity.Comment: 20 pages, 1 figure: v2, references and footnote added, typos
correcte
Genetic Drivers of Heterogeneity in Type 2 Diabetes Pathophysiology
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P \u3c 5 × 10-8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores5 in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes1,2 and molecular mechanisms that are often specific to cell type3,4. Here, to characterize the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study data from 2,535,601 individuals (39.7% not of European ancestry), including 428,452 cases of T2D. We identify 1,289 independent association signals at genome-wide significance (P < 5 × 10-8) that map to 611 loci, of which 145 loci are, to our knowledge, previously unreported. We define eight non-overlapping clusters of T2D signals that are characterized by distinct profiles of cardiometabolic trait associations. These clusters are differentially enriched for cell-type-specific regions of open chromatin, including pancreatic islets, adipocytes, endothelial cells and enteroendocrine cells. We build cluster-specific partitioned polygenic scores5 in a further 279,552 individuals of diverse ancestry, including 30,288 cases of T2D, and test their association with T2D-related vascular outcomes. Cluster-specific partitioned polygenic scores are associated with coronary artery disease, peripheral artery disease and end-stage diabetic nephropathy across ancestry groups, highlighting the importance of obesity-related processes in the development of vascular outcomes. Our findings show the value of integrating multi-ancestry genome-wide association study data with single-cell epigenomics to disentangle the aetiological heterogeneity that drives the development and progression of T2D. This might offer a route to optimize global access to genetically informed diabetes care.</p
Determination of microstructural anisotropy in Sb-InSb eutectic by electrical resistivity measurement
Reproducibility of Temperature-Selected Mass Spectra in Matrix-Assisted Laser Desorption Ionization of Peptides
DEVELOPING TIME-BASED CLUSTERING NEURAL NETWORKS TO USE CHANGE-POINT DETECTION: APPLICATION TO FINANCIAL TIME SERIES
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