Comparison of altered AD-related gene expression profiles between the hippocampus and cerebral cortex.

<p>The relative levels of gene expression are shown, where those of the control mice are defined as 100. The hippocampal <i>Chat</i> data were excluded because of the high C_t values (30</p

Synapse-related gene expressions in the hippocampus.

<p>Synapse-related gene expressions in the hippocampus.</p

AD-related genes investigated in this study.

<p>AD-related genes investigated in this study.</p

Volcano plots of the gene expression changes in icv-STZ mice and 3xTg-AD mice.

<p>Fold changes (FC) in gene expression of icv-STZ mice vs. control mice (A) and 3xTg mice vs. control mice (B). Each dot represents one gene. Green, down-regulated; red, up-regulated.</p

RNA integrity.

<p>Total RNA samples (1.5 µg/lane) extracted from mouse brains were separated in 1.2% native agarose gels and visualized under ultraviolet light.</p

Insulin signaling–related gene expressions in the hippocampus.

<p>Insulin signaling–related gene expressions in the hippocampus.</p

APP- and tau-related gene expressions.

<p>APP- and tau-related gene expressions.</p

Expressions of apoptosis- and autophagy-related genes and transcription factors in the hippocampus.

<p>Expressions of apoptosis- and autophagy-related genes and transcription factors in the hippocampus.</p

Glucose metabolism–related gene expressions in the hippocampus.

<p>Glucose metabolism–related gene expressions in the hippocampus.</p

Comparison of altered AD-related gene expression profiles between the icv-STZ mice and the 3xTg-AD mice.

<p>Comparison of altered AD-related gene expression profiles between the icv-STZ mice and the 3xTg-AD mice.</p