Quantum fluctuations of classical skyrmions in quantum Hall Ferromagnets

In this article, we discuss the effect of the zero point quantum fluctuations to improve the results of the minimal field theory which has been applied to study %SMG the skyrmions in the quantum Hall systems. Our calculation which is based on the semiclassical treatment of the quantum fluctuations, shows that the one-loop quantum correction provides more accurate results for the minimal field theory.Comment: A few errors are corrected. Accepted for publication in Rapid Communication, Phys. Rev.

Anisotropic Transport of Quantum Hall Meron-Pair Excitations

Double-layer quantum Hall systems at total filling factor $\nu_T=1$ can exhibit a commensurate-incommensurate phase transition driven by a magnetic field $B_{\parallel}$ oriented parallel to the layers. Within the commensurate phase, the lowest charge excitations are believed to be linearly-confined Meron pairs, which are energetically favored to align with $B_{\parallel}$. In order to investigate this interesting object, we propose a gated double-layer Hall bar experiment in which $B_{\parallel}$ can be rotated with respect to the direction of a constriction. We demonstrate the strong angle-dependent transport due to the anisotropic nature of linearly-confined Meron pairs and discuss how it would be manifested in experiment.Comment: 4 pages, RevTex, 3 postscript figure

Noninvasively Predicting Hemodynamic Response to Carvedilol in Cirrhotic Patients With Varices: You Have Some Ex-Spleening to Do

Gastroesophageal varices are present in approximately 50% of patients with cirrhosis and variceal hemorrhage occurs at a rate of about 10%–15% per year (N Engl J Med 1988;319:983–989; Gastrointest Endosc 2007;65:82–88). Nonselective beta-blockers (NSBB) or variceal band ligation are currently recommended as primary prophylaxis against variceal hemorrhage in patients with large or high-risk varices (J Hepatol 2015;63:743–752; Hepatology 2017;65:310–335). The goal of NSBB therapy is to reduce portal pressures, which can formally be assessed by measuring the hepatic venous pressure gradient (HVPG)

COVID-19 and liver disease: mechanistic and clinical perspectives

Our understanding of the hepatic consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its resultant coronavirus disease 2019 (COVID-19) has evolved rapidly since the onset of the pandemic. In this Review, we discuss the hepatotropism of SARS-CoV-2, including the differential expression of viral receptors on liver cell types, and we describe the liver histology features present in patients with COVID-19. We also provide an overview of the pattern and relevance of abnormal liver biochemistry during COVID-19 and present the possible underlying direct and indirect mechanisms for liver injury. Furthermore, large international cohorts have been able to characterize the disease course of COVID-19 in patients with pre-existing chronic liver disease. Patients with cirrhosis have particularly high rates of hepatic decompensation and death following SARS-CoV-2 infection and we outline hypotheses to explain these findings, including the possible role of cirrhosis-associated immune dysfunction. This finding contrasts with outcome data in pharmacologically immunosuppressed patients after liver transplantation who seem to have comparatively better outcomes from COVID-19 than those with advanced liver disease. Finally, we discuss the approach to SARS-CoV-2 vaccination in patients with cirrhosis and after liver transplantation and predict how changes in social behaviours and clinical care pathways during the pandemic might lead to increased liver disease incidence and severity. © 2021, Springer Nature Limited

Letter to the Editor: Proton Pump Inhibitors in Cirrhosis: A Marker of Morbid Conditions or a Cause of Mortality?

We read with interest the study by Nardelli et al., which adds to a growing literature on the potential ills of proton pump inhibitors (PPIs) in patients with cirrhosis. Their prospective design allowed for assessment of minimal hepatic encephalopathy (HE), and they reported that PPI use was independently associated with minimal HE, overt HE, and mortality. While we applaud the authors’ efforts, we are concerned about residual confounding that may have led to misinterpretation of mortality results

A Compositional Semantics for Stochastic Reo Connectors

In this paper we present a compositional semantics for the channel-based coordination language Reo which enables the analysis of quality of service (QoS) properties of service compositions. For this purpose, we annotate Reo channels with stochastic delay rates and explicitly model data-arrival rates at the boundary of a connector, to capture its interaction with the services that comprise its environment. We propose Stochastic Reo automata as an extension of Reo automata, in order to compositionally derive a QoS-aware semantics for Reo. We further present a translation of Stochastic Reo automata to Continuous-Time Markov Chains (CTMCs). This translation enables us to use third-party CTMC verification tools to do an end-to-end performance analysis of service compositions. As a case study, we are currentl

Gallbladder agenesis mimicking cholelithiasis in an adult

We present the case of a 24-year-old woman with morbid obesity who came to the emergency department with right upper quadrant abdominal pain associated with nausea and vomiting. Her workup included a right upper quadrant ultrasound suggestive of a small gallbladder with cholelithiasis without sonographic evidence of acute cholecystitis. She underwent attempted laparoscopic cholecystectomy with no identifiable gallbladder during surgery. Postsurgical cross-sectional imaging confirmed gallbladder agenesis. This case provides an example of a rare but convincing clinical and radiologic mimic of cholelithiasis. In certain cases of biliary colic and imaging revealing a small gallbladder, a magnetic resonance cholangiopancreatography may be warranted to evaluate gallbladder agenesis and avoid unnecessary surgery

Immunosuppression in Autoimmune Hepatitis: Is There an End Game?

Autoimmune hepatitis (AIH) is a rare, chronic disease associated with the development of cirrhosis and premature mortality. Current guidelines state that patients with AIH should receive induction therapy with corticosteroids or the combination of corticosteroids/azathioprine, followed by maintenance therapy with lower doses of steroids and/or azathioprine (1–3). However, the optimal strategy for the ongoing treatment beyond this point remains unclear

Spin-squeezed Ground States in the Bilayer Quantum Hall Ferromagnet

A "squeezed-vacuum" state considered in quantum optics is shown to be realized in the ground-state wavefunction for the bilayer quantum Hall system at the total Landau level filling of $\nu=1/m$ (m: odd integer). This is derived in the boson approximation, where a particle-hole pair creation across the symmetric-antisymmetric gap, $\Delta_{SAS}$, is regarded as a boson. In terms of the pseudospin describing the layers, the state is a spin-squeezed state, where the degree of squeezing is controlled by the layer separation and $\Delta_{SAS}$. An exciton condensation, which amounts to a rotated spin-squeezed state, has a higher energy due to the degraded SU(2) symmetry for $\Delta_{SAS} \neq 0$.Comment: 4 pages, revtex, one figure, to appear in PRB Rapid Communicatio

Determining risk factors for mortality in liver transplant patients with COVID-19

We read with great interest the Correspondence from Bhoori and colleagues1 describing the effect of coronavirus disease 2019 (COVID-19) on their centre's adult liver transplant population.1 Within their cohort of over 150 transplant recipients, the authors identified six patients with COVID-19, including three resulting deaths. Each of those who died was transplanted over 10 years previously and were older than 65 years, male, overweight, and had hypertension and diabetes. The authors speculated as to whether these characteristics might be major risk factors for mortality