Supernova neutrino detection in Borexino

In this paper, the performances of Borexino as a Supernova neutrino detector are analyzed and discussed. The expected neutrino signal from a typical Type II Supernova at a distance of 10 kpc is calculated: a burst of around 240 events would appear in Borexino within a time interval of about 10 s. Most of these events would come from the reaction channels ¯νe + p → e+ + n and ν + p → ν + p, while about 30 events would be induced by the interaction of the Supernova neutrino flux on 12C in the liquid scintillator: for most of these reactions, Borexino features unique detection capabilities, thanks to its low-energy sensitivity, ultra-low radioactive background and large homogeneous volume. The possibility to tag and identify the different neutrino detection reactions gives access to key information concerning Supernova physics and non-standard neutrino properties. The detection of neutrinos via elastic scattering off protons in Borexino is discussed here for the first time: this reaction is proven to be a powerful component of the neutrino-induced burst of events. Finally, a viable “Supernova trigger” condition is established, which allows to detect a Supernova explosion up to a distance of 63 kpc

Towards a Powerful Hardware‐in‐the‐Loop System for Virtual Calibration of an Off‐Road Diesel Engine

A common challenge among internal combustion engine (ICE) manufacturers is shorten-ing the development time while facing requirements and specifications that are becoming more complex and border in scope. Virtual simulation and calibration are effective instruments in the face of these demands. This article presents the development of zero‐dimensional (0D)—real‐time engine and exhaust after‐treatment system (EAS) models and their deployment on a Virtual test bench (VTB). The models are created using a series of measurements acquired in a real test bench, carefully performed in view of ensuring the highest reliability of the models themselves. A zero‐dimensional approach was chosen to guarantee that models could be run in real‐time and interfaced to the real engine Electronic Control Unit (ECU). Being physically based models, they react to changes in the ECU calibration parameters. Once the models are validated, they are then integrated into a Sim-ulink® based architecture with all the Inputs/Outputs connections to the ECU. This Simulink® model is then deployed on a Hardware in the Loop (HiL) machine for ECU testing and calibration. The results for engine and EAS performance and emissions align with both steady‐state and transient measurements. Finally, two different applications of the HiL system are presented to explain the opportunities and advantages of this tool integrated within the standard engine development. Ex-amples cited refer to altitude calibration activities and soot loading investigation on vehicle duty cycles. The cases described in this work are part of the actual development of one of the latest engines developed by Kohler Engines: the KDI 1903 TCR Stage V. The application of this methodology reveals a great potential for engine development and may become an essential tool for calibration engineers

Effect of strain in the proximal ligand on the binding of nitric oxide and carbon monoxide to chelated protoheme complexes

The binding of NO and CO to chelated protoheme-L-histidine methyl ester (HM-H), protoheme-glycyl-L-histidine methyl ester (HM-GH), and free protoheme (HM) has been studied in methanol-DMSO solution. In all cases, the NO adducts are five-coordinated indicating that binding of NO occurs with displacement of the axial base and confirms the strong negative trans effect exerted by NO in heme complexes, though it is found that the presence of strain in the iron-histidine bond of HM-H has a positive influence on NO binding, making it thermodynamically more favorable than for HM-GH. The equilibrium constants thus decrease in the series HM>HM-H>HM-GH. In contrast to NO, CO has a positive trans effect, and therefore, an opposite trend is observed in the binding of this ligand to the heme complexe

The Social Exclusion Bench Tool (SEBT): A visual way of assessing interpersonal social exclusion

People usually prefer to appear with an inclusive and positive attitude to others’ eyes. For this reason, the self-report scales assessing social exclusion intentions are often biased by social desirability. In this work, we present an innovative graphical tool, named Social Exclusion Bench Tool (SEBT), for assessing social exclusion not influenced by social desirability. The tool is based on the consistency between social distance and physical distance evaluation. The results showed that in two samples of adults from Italy (N = 252) and the UK (N = 254), the SEBT positively correlated with self-report measures of social exclusion, but not with the social desirability measure. The tool has been preliminarily evaluated in the context of social exclusion toward migrant people, but it appears a promising instrument for assessing social exclusion intentions toward different social groups. • The self-report scales assessing social exclusion intentions are often biased by social desirability. • The Social Exclusion Bench Tool (SEBT) is an innovative visual instrument for assessing social exclusion that seems not to be influenced by social desirability. • The tool appears a promising instrument for assessing social exclusion intentions toward different social groups

New Measurement of the Relative Scintillation Efficiency of Xenon Nuclear Recoils Below 10 keV

Liquid xenon is an important detection medium in direct dark matter experiments, which search for low-energy nuclear recoils produced by the elastic scattering of WIMPs with quarks. The two existing measurements of the relative scintillation efficiency of nuclear recoils below 20 keV lead to inconsistent extrapolations at lower energies. This results in a different energy scale and thus sensitivity reach of liquid xenon dark matter detectors. We report a new measurement of the relative scintillation efficiency below 10 keV performed with a liquid xenon scintillation detector, optimized for maximum light collection. Greater than 95% of the interior surface of this detector was instrumented with photomultiplier tubes, giving a scintillation yield of 19.6 photoelectrons/keV electron equivalent for 122 keV gamma rays. We find that the relative scintillation efficiency for nuclear recoils of 5 keV is 0.14, staying constant around this value up to 10 keV. For higher energy recoils we measure a value around 20%, consistent with previously reported data. In light of this new measurement, the XENON10 experiment's results on spin-independent WIMP-nucleon cross section, which were calculated assuming a constant 0.19 relative scintillation efficiency, change from $8.8\times10^{-44}$ cm$^2$ to $9.9\times10^{-44}$ cm$^2$ for WIMPs of mass 100 GeV/c$^2$, and from $4.4\times10^{-44}$ cm$^2$ to $5.6\times10^{-44}$ cm$^2$ for WIMPs of mass 30 GeV/c$^2$.Comment: 8 pages, 8 figure

Validation of the Italian version of the abbreviated expanded prostate Cancer index composite (EPIC-26) in men with prostate Cancer

Background: This study aims to validate and evaluate the psychometric properties and reliability of the Italian version of the Expanded Prostate Cancer Index Composite - Short Form (EPIC-26), a measure of quality of life (QoL) for prostate cancer patients. Methods: Two hundred and eighty-four prostate cancer patients completed the Italian version of the EPIC-26 questionnaire at 45 days (T1) and 3 months (T2) after robot-assisted radical prostatectomy (RARP). Psychometric properties were evaluated using structural equation modeling: the goodness of fit of the correlated five-factor model (CFFM) for the EPIC-26 was assessed using the confirmatory factor analysis (CFA), while longitudinal invariance was conducted to assess the ability of the EPIC-26 to measure QoL construct over time. Test-retest reliability was assessed as well by considering intraclass correlations. Results: At T1, the CFFM model displayed a good fit to data. Similarly, the model showed an adequate fit also at T2. Results of the reliability analysis attested the acceptable internal consistency and test-retest reliability of each dimension: all Cronbach's alphas could be classified as acceptable (i.e., above.65) except for low Cronbach's alpha for hormonal dysfunction at T1 (i.e.,.638) and urinary irritation at both waves. (i.e., respectively.585 and.518). Finally, psychometric properties were invariant over time and each of the five dimensions of QoL displayed from moderate (all ICCs above.500) to good test-retest reliability (i.e. ICC for urinary incontinence =.764). Conclusions: Results of the CFA and the measurement invariance analysis demonstrated the validity of the Italian version of the EPIC-26 to assess QoL in prostate cancer patients. Its reliability and good psychometric qualities are well-supported, thus providing a valid tool to assess health-related quality of life and its change over time in prostate cancer patients

From virtual to real healing: a critical overview of the therapeutic use of virtual reality to cope with mourning

In recent years, virtual reality (VR) has been effectively employed in several settings, ranging from health care needs to leisure and gaming activities. A new application of virtual stimuli appeared in social media: in the documentary ‘I met you’ from the South-Korean Munhwa Broadcasting, a mother made the experience of interacting with the avatar of the seven-year-old daughter, who died four years before. We think that this new application of virtual stimuli should open a debate on its possible implications: it represents contents related to grief, a dramatic and yet natural experience, that can have deep psychological impacts on fragile subjects put in virtual environments. In the present work, possible side-effects, as well as hypothetical therapeutical application of VR for the treatment of mourning, are discussed

Validation of the Italian version of the abbreviated expanded prostate Cancer index composite (EPIC-26) in men with prostate Cancer

Background: This study aims to validate and evaluate the psychometric properties and reliability of the Italian version of the Expanded Prostate Cancer Index Composite - Short Form (EPIC-26), a measure of quality of life (QoL) for prostate cancer patients. Methods: Two hundred and eighty-four prostate cancer patients completed the Italian version of the EPIC-26 questionnaire at 45 days (T1) and 3 months (T2) after robot-assisted radical prostatectomy (RARP). Psychometric properties were evaluated using structural equation modeling: the goodness of fit of the correlated five-factor model (CFFM) for the EPIC-26 was assessed using the confirmatory factor analysis (CFA), while longitudinal invariance was conducted to assess the ability of the EPIC-26 to measure QoL construct over time. Test-retest reliability was assessed as well by considering intraclass correlations. Results: At T1, the CFFM model displayed a good fit to data. Similarly, the model showed an adequate fit also at T2. Results of the reliability analysis attested the acceptable internal consistency and test-retest reliability of each dimension: all Cronbach's alphas could be classified as acceptable (i.e., above.65) except for low Cronbach's alpha for hormonal dysfunction at T1 (i.e.,.638) and urinary irritation at both waves. (i.e., respectively.585 and.518). Finally, psychometric properties were invariant over time and each of the five dimensions of QoL displayed from moderate (all ICCs above.500) to good test-retest reliability (i.e. ICC for urinary incontinence =.764). Conclusions: Results of the CFA and the measurement invariance analysis demonstrated the validity of the Italian version of the EPIC-26 to assess QoL in prostate cancer patients. Its reliability and good psychometric qualities are well-supported, thus providing a valid tool to assess health-related quality of life and its change over time in prostate cancer patients

Intra-host evolution of multiple genotypes of hepatitis C virus in a chronically infected patient with HIV along a 13-year follow-up period

AbstractThe intra-host evolutionary process of hepatitis C virus (HCV) was analyzed by phylogenetic and coalescent methodologies in a patient co-infected with HCV-1a, HCV-2a, HCV-3a and human immunodeficiency virus (HIV) along a 13-year period.Direct sequence analysis of the E2 and NS5A regions showed diverse evolutionary dynamics, in agreement with different relationships between these regions and the host factors.The Bayesian Skyline Plot analyses of the E2 sequences (cloned) yielded different intra-host evolutionary patterns for each genotype: a steady state of a “consensus” sequence for HCV-1a; a pattern of lineage splitting and extinction for HCV-2a; and a two-phase (drift/diversification) process for HCV-3a.Each genotype evolving in the same patient and at the same time presents a different pattern apparently modulated by the immune pressure of the host.This study provides useful information for the management of co-infected patients and provides insights into the mechanisms behind the intra-host evolution of HCV

The situational version of the brief COPE: Dimensionality and relationships with goal-related variables

This study is aimed at investigating the dimensionality of the situational version of the Brief COPE, a questionnaire that is frequently used to assess a broad range of coping responses to specific difficulties, by comparing five different factor models highlighted in previous studies. It also aimed at exploring the relationships among coping responses, personal goal commitment and progress. The study involved 606 adults (male = 289) ranging in age from 19 to 71. Using confirmatory factor analysis, we compared five models and assessed relationships of coping responses with goal commitment and progress. The results confirmed the theoretical factor structure of the situational Brief COPE. All the 14 dimensions showed acceptable reliability and relationships with goal commitment and progress, attesting the reliability and usefulness of this measure to evaluate coping responses to specific events