Main data in patients included in the study.

<p>Main data in patients included in the study.</p

Association between Occupational Exposure to Wood Dust and Cancer: A Systematic Review and Meta-Analysis

<div><p>Objective</p><p>To perform a systematic review to analyze the association between occupational exposure to wood dust and cancer.</p><p>Methods</p><p>A systematic literature search of entries made in the MEDLINE-PubMed database between 1957 and 2013 was conducted to identify studies that had assessed the relationship between occupational exposure to wood dust and different types of cancer. A meta-analysis of selected case-control and cohort studies was subsequently performed.</p><p>Results</p><p>A total of 114 studies were identified and 70 were selected for review. Of these, 42 studies focused on the relationship between wood dust and nasal cancer (n = 22), lung cancer (n = 11), and other types of cancer (n = 9). Low-to-moderate quality evidence that wood dust acts as a carcinogen was obtained, and a stronger association between wood dust and nasal adenocarcinoma was observed. A lesser association between wood dust exposure and lung cancer was also observed. Several studies suggested that there is a relationship between wood dust and the onset of other cancers, although there was no evidence to establish an association. A meta-analysis that included four case-controls studies showed that workers exposed to wood dust exhibited higher rates of nasal adenocarcinoma than other workers (odds ratio = 10.28; 95% confidence interval: 5.92 and 17.85; <i>P</i><0,0001), although a large degree of heterogeneity was found.</p><p>Conclusions</p><p>Low-to-moderate quality evidence supports a causal association between cancer and occupational exposure to wood dust, and this association was stronger for nasal adenocarcinoma than for lung cancer. There was no evidence of an association between wood dust exposure and the other cancers examined.</p></div

Distribution of the cohort by age groups.

<p>Distribution of the cohort by age groups.</p

Temporal distribution of cohort during the study period: Cases and anual incidence rate <i>(cases per 105 person-years</i>).

<p>Data of Minimum Basic Data Set 1998–2014.</p

Logistic regression model: Pediatric population <i>vs</i> Adult population.

<p>Logistic regression model: Pediatric population <i>vs</i> Adult population.</p

Costs per year of admission and diagnosis.

<p>Costs per year of admission and diagnosis.</p

Temporal evolution of the publications related to wood dust exposure and cancer incidence that are indexed in Medline.

<p>Temporal evolution of the publications related to wood dust exposure and cancer incidence that are indexed in Medline.</p

Summary of published results on the relationship between exposure to wood dust and other types of cancer.

<p>^a/bQuality of evidence according to US Task Force on Preventive Health Care 1989 (first column)/Centre for Evidence-based Medicine, Oxford (second column).</p><p>ADCN: adenocarcinoma; OR: odds ratio; RR: relative risk; CI: confidence interval.</p><p>Summary of published results on the relationship between exposure to wood dust and other types of cancer.</p

A PRISMA flowchart that illustrates the search strategy used to identify articles included in this systematic review.

<p>A PRISMA flowchart that illustrates the search strategy used to identify articles included in this systematic review.</p

Summary of published results on the relation between exposure to wood dust and nasal cancer—adenocarcinoma (ADCN).

<p>^a/bQuality of evidence according to US Task Force on Preventive Health Care 1989 (first column)/Centre for Evidence-based Medicine, Oxford (second column).</p><p>^cNo. of ADCN cases, unless otherwise specified.</p><p>ADCN: adenocarcinoma; OR: odds ratio; RR: relative risk; SIR: standardized incidence ratio; CI: confidence interval.</p><p>Summary of published results on the relation between exposure to wood dust and nasal cancer—adenocarcinoma (ADCN).</p