Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease

BACKGROUND: The recent growing evidence that the proximal tubule underlies the early pathogenesis of diabetic kidney disease (DKD) is unveiling novel and promising perspectives. This pathophysiological concept links tubulointerstitial oxidative stress, inflammation, hypoxia, and fibrosis with the progression of DKD. In this new angle for DKD, the prevailing molecular mechanisms on proximal tubular cells emerge as an innovative opportunity for prevention and management of DKD as well as to improve diabetic dysmetabolism. SUMMARY: The mercapturate pathway (MAP) is a classical metabolic detoxification route for xenobiotics that is emerging as an integrative circuitry detrimental to resolve tubular inflammation caused by endogenous electrophilic species. Herein we review why and how it might underlie DKD. Key Messages: MAP is a hallmark of proximal tubular cell function, and cysteine-S-conjugates might represent targets for early intervention in DKD. Moreover, the biomonitoring of urinary mercapturates from metabolic inflammation products might be relevant for the implementation of preventive/management strategies in DKD.info:eu-repo/semantics/publishedVersio

Ferromagnetic Ga₁ˍₓ Mnₓ As produced by ion implantation and pulsed-laser melting

We demonstrate the formation of ferromagneticGa₁ˍₓMnₓAsfilms by Mn ion implantation into GaAs followed by pulsed-laser melting. Irradiation with a single excimer laser pulse results in the epitaxial regrowth of the implanted layer with Mn substitutional fraction up to 80% and effective Curie temperature up to 29 K for samples with a maximum Mn concentration of x≈0.03. A remanent magnetization persisting above 85 K has been observed for samples with x≈0.10, in which 40% of the Mn resides on substitutional lattice sites. We find that the ferromagnetism in Ga₁ˍₓMnₓAs is rather robust to the presence of structural defects.The work at the Lawrence Berkeley National Laboratory was supported by the Director, Office of Science, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering, of the U.S. Department of Energy under Contract No. DE-AC03-76SF00098. The work at Harvard was supported by NASA Grant No. NAG8-1680. One of the authors ~M.A.S.! acknowledges support from an NSF Graduate Research Fellowship

Avaliação de consumo de farelo da torta de amêndoa de palma de óleo em bubalinos.

O experimento teve como objetivo avaliar o consumo diário em bubalinos suplementados com torta de amêndoa de Palma de Óleo para subsidiar estratégias de adoção desses subprodutos nas dietas dos animais. Na Fazenda Senador Álvaro Adolpho da Embrapa/Projeto PECUS, participou-se de experimentos com 4 búfalos em delineamento experimental fatorial de 4 animais x 4 tratamentos. Dietas foram fornecidas em cochos e as sobras eram pesadas e analisadas. Foram aplicadas 4 dietas, sendo uma sem farelo da torta de Palma de Óleo (dieta controle) e, três com diferentes proporções de farelo de amêndoa. Os quatro animais participaram do rodízio de dietas, nas quatro fases, desse planejamento experimental que durava 20 dias cada fase. Na primeira fase, os resultados evidenciaram que nos primeiros 9 dias de aplicação das dietas, houve rejeição pelos três animais que receberam suplemento com adição do farelo de amêndoa. Já o farelo de trigo foi preferência unanime para todos os animais quando foram submetidos à dieta controle. Ao receber pela primeira vez o farelo de amêndoa, um animal (n°4) expressou dificuldades em adaptação, deixando em média 1,2 kg no cocho. A dieta que expressou maiores ganhos de peso durante os 90 dias de experimento foi com suplementação farelo de trigo adicionada ao farelo de amêndoa de Palma de óleo. Essas evidências podem ser uma alternativa suplementar, em períodos de baixa oferta de forragem. Dietas utilizando coprodutos de Palma de Óleo permitem a mantença e, podem minimizar as emissões de GEE em períodos de baixa oferta de pastagens.VII ENAAg

Ultra-processed food consumption and risk of obesity: a prospective cohort study of UK Biobank

Objective: To examine the associations between ultra-processed food consumption and risk of obesity among UK adults. Methods: Participants aged 40-69 years at recruitment in the UK Biobank (2006-2019) with dietary intakes collected using 24-hour recall and repeated measures of adiposity - body mass index (BMI), waist circumference (WC) and percentage of body fat (% BF) - were included (N=22,659; median follow-up: 5 years). Ultra-processed foods were identified using the NOVA classification and their consumption was expressed as a percentage of total energy intake. Multivariable Cox proportional hazards regression models were used to estimate hazard ratios (HR) of several indicators of obesity according to ultra-processed food consumption. Models were adjusted for sociodemographic and lifestyle characteristics. Results: 947 incident cases of overall obesity (BMI≥30 kg/m2) and 1,900 incident cases of abdominal obesity (men: WC≥102cm, women: WC≥88cm) were identified during follow-up. Participants in the highest quartile of ultra-processed food consumption had significantly higher risk of developing overall obesity (HR: 1.79; 95%CI: 1.06─3.03) and abdominal obesity (HR: 1.30; 95%CI: 1.14─1.48). They had higher risk of experiencing a ≥5% increase in BMI (HR: 1.31; 95%CI: 1.20─1.43), WC (HR: 1.35; 95%CI: 1.25─1.45) and %BF (HR: 1.14; 95%CI: 1.03─1.25), than those in the lowest quartile of consumption. Conclusions: Our findings provide evidence that higher consumption of ultra-processed food is strongly associated with a higher risk of multiple indicators of obesity in the UK adult population. Policy makers should consider actions that promote consumption of fresh or minimally processed foods and reduce consumption of ultra-processed foods

Estratégia reprodutiva do maracujá amarelo (Passiflora edulis Sims F. flavicarpa Deg) em área irrigada do Vale do Submédio São Francisco.

O objetivo deste trabalho foi verificar a estratégia reprodutiva de P. edulis, em cultivo irrigado no projeto Maniçoba, em JuazeiroBA

Attention deficits predict phenotypic outcomes in syndrome-specific and domain-specific ways

Attentional difficulties, both at home and in the classroom, are reported across a number of neurodevelopmental disorders. However, exactly how attention influences early socio-cognitive learning remains unclear. We addressed this question both concurrently and longitudinally in a cross-syndrome design, with respect to the communicative domain of vocabulary and to the cognitive domain of early literacy, and then extended the analysis to social behavior. Participants were young children (aged 4–9 years at Time 1) with either Williams syndrome (WS, N = 26) or Down syndrome (DS, N = 26) and typically developing controls (N = 103). Children with WS displayed significantly greater attentional deficits (as indexed by teacher report of behavior typical of attention deficit hyperactivity disorder (ADHD) than children with DS, but both groups had greater attentional problems than the controls. Despite their attention differences, children with DS and those with WS were equivalent in their cognitive abilities of reading single words, both at Time 1 and 12 months later, at Time 2, although they differed in their early communicative abilities in terms of vocabulary. Greater ADHD-like behaviors predicted poorer subsequent literacy for children with DS, but not for children with WS, pointing to syndrome-specific attentional constraints on specific aspects of early development. Overall, our findings highlight the need to investigate more precisely whether and, if so, how, syndrome-specific profiles of behavioral difficulties constrain learning and socio-cognitive outcomes across different domains