Prognostic and theranostic applications of positron emission tomography for a personalized approach to metastatic castration‐resistant prostate cancer

Metastatic castration‐resistant prostate cancer (mCRPC) represents a condition of pro-gressive disease in spite of androgen deprivation therapy (ADT), with a broad spectrum of mani-festations ranging from no symptoms to severe debilitation due to bone or visceral metastatization. The management of mCRPC has been profoundly modified by introducing novel therapeutic tools such as antiandrogen drugs (i.e., abiraterone acetate and enzalutamide), immunotherapy through sipuleucel‐T, and targeted alpha therapy (TAT). This variety of approaches calls for unmet need of biomarkers suitable for patients’ pre‐treatment selection and prognostic stratification. In this sce-nario, imaging with positron emission computed tomography (PET/CT) presents great and still unexplored potential to detect specific molecular and metabolic signatures, some of whom, such as the prostate specific membrane antigen (PSMA), can also be exploited as therapeutic targets, thus combining diagnosis and therapy in the so‐called “theranostic” approach. In this review, we per-formed a web‐based and desktop literature research to investigate the prognostic and theranostic potential of several PET imaging probes, such as18F‐FDG,18F‐choline and68Ga‐PSMA‐11, also covering the emerging tracers still in a pre‐clinical phase (e.g., PARP‐inhibitors’ analogs and the radioligands binding to gastrin releasing peptide receptors/GRPR), highlighting their potential for defining personalized care pathways in mCRPC

A New Hybrid Debugging Architecture for Eclipse

The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-14125-1_11[EN] During many years, print debugging has been the most used method for debugging. Nowadays, however, industrial languages come with a trace debugger that allows programmers to trace computations step by step using breakpoints and state viewers. Almost all modern programming environments include a trace debugger that allows us to inspect the state of a computation in any given point. Nevertheless, this debugging method has been criticized for being completely manual and time-consuming. Other debugging techniques have appeared to solve some of the problems of Trace Debugging, but they suffer from other problems such as scalability. In this work we present a new hybrid debugging technique. It is based on a combination of Trace Debugging, Algorithmic Debugging and Omniscient Debugging to produce a synergy that exploits the best properties and strong points of each technique. We describe the architecture of our hybrid debugger and our implementation that has been integrated into Eclipse as a plugin.This work has been partially supported by the Spanish Ministerio de Economía y Competitividad (Secretaria de Estado de Investigación, Desarrollo e Innovación) under grant TIN2008-06622-003-02 and by the Generalitat Valenciana under grant PROMETEO/2011/052. David Insa was partially supported by the Spanish Ministerio de Educación under FPU grant AP2010-4415.González, J.; Insa Cabrera, D.; Silva Galiana, JF. (2013). A New Hybrid Debugging Architecture for Eclipse. En Logic-Based Program Synthesis and Transformation. Springer. 183-201. doi:10.1007/978-3-319-14125-1_11S183201Swi-prolog (1987). http://www.swi-prolog.org/Netbeans (1999). http://www.netbeans.org/Eclipse (2003). http://www.eclipse.org/Omnicore codeguide (2007). http://www.omnicore.com/en/codeguide.htmBorland JBuilder (2008). http://www.embarcadero.com/products/jbuilder/Sicstus prolog spider ide (2009). https://sicstus.sics.se/spider/Caballero, R.: A Declarative Debugger of Incorrect Answers for Constraint Functional-Logic Programs. In: Proceedings of the 2005 ACM-SIGPLAN Workshop on Curry and Functional Logic Programming (WCFLP 2005), pp. 8–13. ACM Press, New York (2005)Davie, T., Chitil, O.: Hat-delta: One Right Does Make a Wrong. In: Proceedings of the 7th Symposium on Trends in Functional Programming (TFP 2006) (April 2006)Gestwicki, P., Jayaraman, B.: JIVE: Java Interactive Visualization Environment. In: Companion to the 19th Annual ACM-SIGPLAN Conference on Object-Oriented Programming Systems, Languages, and Applications (OOPSLA 2004), pp. 226–228. ACM Press, New York (2004)Giammona, D.: ORACLE ADF - Putting It Together. Technical report, ADF Declarative Debugger Archives (November 2009)Girgis, H., Jayaraman, B.: JavaDD: a Declarative Debugger for Java. Technical report,University at Buffalo (2006)González, F., De Miguel, R., Serrano, S.: Depurador Declarativo de Programas Java. Technical report, Universidad Complutense de Madrid (2006). http://eprints.ucm.es/9114/Hermanns, C., Kuchen, H.: Hybrid Debugging of Java Programs. In: Escalona, M.J., Cordeiro, J., Shishkov, B. (eds.) ICSOFT 2011. CCIS, vol. 303, pp. 91–107. Springer, Heidelberg (2013)Montebello, M., Abela, C.: Design and Implementation of a Backward-In-Time. In: Chaudhri, A.B., Jeckle, M., Rahm, E., Unland, R. (eds.) NODe-WS 2002. LNCS, vol. 2593, pp. 46–58. Springer, Heidelberg (2003)Insa, D., Silva, J.: An Algorithmic Debugger for Java. In: Proceedings of the 26th IEEE International Conference on Software Maintenance (ICSM 2010), pp. 1–6 (2010)Insa, D., Silva, J.: Scaling Up Algorithmic Debugging with Virtual Execution Trees. In: Alpuente, M. (ed.) LOPSTR 2010. LNCS, vol. 6564, pp. 149–163. Springer, Heidelberg (2011)Insa, D., Silva, J.: loops2recursion Java Library (2013). http://www.dsic.upv.es/~jsilva/loops2recursion/Kouh, H.-J., Yoo, W.-H.: The Efficient Debugging System for Locating Logical Errors in Java Programs. In: Kumar, V., Gavrilova, M.L., Kenneth Tan, C.J., L’Ecuyer, P. (eds.) ICCSA 2003. LNCS, vol. 2667, pp. 684–693. Springer, Heidelberg (2003)B. Lewis. Debugging Backwards in Time. Available in the Computing Research Repository 2003, ( http://arxiv.org/abs/cs.SE/0310016 ), cs.SE/0310016Lienhard, A., Gîrba, T., Wang, J.: Practical Object-Oriented Back-in-Time Debugging. In: Vitek, J. (ed.) ECOOP 2008. LNCS, vol. 5142, pp. 592–615. Springer, Heidelberg (2008)S. Microsystems. Java Platform Debugger Architecture - JPDA (2010). http://java.sun.com/javase/technologies/core/toolsapis/jpda/Mirghasemi, S., Barton, J., Petitpierre, C.: Debugging by lastChange. Technical report (2011). http://people.epfl.ch/salman.mirghasemiNilsson, H.: Declarative Debugging for Lazy Functional Languages. PhD thesis, Linköping, Sweden (May 1998)Nilsson, H., Fritzson, P.: Algorithmic Debugging for Lazy Functional Languages. Journal of Functional Programming 4(3), 337–370 (1994)Pothier, G.: Towards Practical Omniscient Debugging. PhD thesis, University of Chile (June 2011)Shapiro, E.: Algorithmic Program Debugging. MIT Press (1982)Silva, J.: A Survey on Algorithmic Debugging Strategies. Advances in Engineering Software 42(11), 976–991 (2011

Principais regiões produtoras e de comercialização: o fluxo de abastecimento da mandioquinha-salsa.

O presente trabalho tem como objetivo apresentar o fluxo de abastecimento, entre as regiões de produção e de comercialização de mandioquinha-salsa, entre os anos de 2016 e 2020. Mais especif camente, busca identifIcar as regiões que apresentaram maior contribuição relativa em termos de volume do produto ofertado, além das centrais de abastecimento que receberam maiores volumes de mandioquinha-salsa. Para alcançar o propósito deste estudo, a pesquisa teve abordagem exploratório-descritiva e utilizou informações secundárias, principalmente do site da Companhia Nacional de Abastecimento (Conab), particularmente a base de dados da Prohort ? Simab. Os resultados alcançados revelaram que, no período levantado na presente pesquisa, de 2016 a 2020, foram comercializadas cerca de 55.167 t, com destaque para o ano de 2017, com o maior percentual de volume comercializado no período (23%). A taxa geométrica de crescimento da quantidade comercializada de mandioquinha-salsa no período foi de 3,14% a.a. Em termos regionais, a região Sudeste se destaca na comercialização de mandioquinha-salsa em todo o período analisado. Em média, considerando todo o período, a região Sudeste teve participação de 66,68% no total comercializado por região, seguido da região Sul, com 32,50%, da região Nordeste, com 2,23% e, por f m, da região Centro-Oeste, com 0,8% de participação. Os resultados também apontaram que as centrais de abastecimento (Ceasas) de Minas Gerais, São Paulo e Paraná representaram os maiores mercados atacadistas para a mandioquinha-salsa, sendo também os principais estados fornecedores do produto. Conclui-se que o presente trabalho contribuiu para a análise do fluxo de abastecimento entre as regiões de produção e de comercialização da mandioquinha-salsa, destacando que as principais regiões produtoras e seus respetivos estados concentram o abastecimento nas próprias regiões.O número se refere a edição dos anais do 59º Congresso da Sociedade Brasileira de Economia, Administração e Sociologia Rural (Sober) e 6º Encontro Brasileiro de Pesquisadores em Cooperativismo (EBPC), Manaus, 2022. Ações coletivas e resiliência: inovações políticas, socieconômicas e ambientai

Rastreabilidade, hortaliças hidropônicas e informações: o que pensam os consumidores.

O objetivo deste artigo é verificar se os consumidores de hortaliças possuem conhecimento sobre algumas características de hortaliças ao serem consumidas e se esse conhecimento teria alguma relação com o nível de renda desses consumidores. Os dados para a análise são primários e obtidos por meio da aplicação de um questionário on line composto por questões fechadas de múltipla escolha, dentre as quais constavam a faixa de renda da família do respondente, se sabem o que é rastreabilidade, se sabem o que é uma hortaliça hidropônica e se se pagariam um valor acima de mercado, caso possuíssem mais informações como: se a hortaliça fosse embalada, higienizada, produzida de forma hidropônica; sem agrotóxicos e se souber sua origem. O questionário foi divulgado em redes sociais e, mediante a amostragem não probabilística por meio de cadeias de referência conhecida como ?bola de neve?, foi possível obter 852 respostas de pessoas que residiam em 186 cidades do Brasil, com ênfase em Brasília, Porto Alegre, São Paulo e Salvador. O referencial teórico considerado é o Marketing alimentar com ênfase no marketing de produto e baseado no comportamento do consumidor. Como principal resultado tem-se que 42,49% sabem o que é rastreabilidade e 91,67% sabem o que é uma hortaliça hidropônica. Sobre a disposição a pagar um valor acima de mercado, verificou que 76,76% preferem ser mais informados sobre hortaliças e quanto maior a diferença do valor em relação aos produtos tradicionais menor é a disposição a pagar, sendo que a maioria aceitaria pagar o valor de até 25% acima do que é oferecido no mercado. O conjunto de respostas obtido, obviamente, não é uma amostra da sociedade brasileira, tendo se concentrado em estratos sociais mais abastados. Contudo, favorece um foco analítico sobre os consumidores de hortaliças e apresenta pontos importantes para a construção e estratégias de comercialização para esse tipo de alimento.SOBER 2023

High Effectiveness of Broad Access Direct-Acting Antiviral Therapy for Hepatitis C in an Australian Real-World Cohort: The REACH-C Study

Australia was one of the first countries with unrestricted access to government subsidized direct-acting antiviral (DAA) therapy for adults with chronic hepatitis C virus. This study assessed real-world DAA treatment outcomes across a diverse range of Australian clinical services and evaluated factors associated with successful treatment and loss to follow-up. Real-world Effectiveness of Antiviral therapy in Chronic Hepatitis C (REACH-C) consisted a national observational cohort of 96 clinical services including specialist clinics and less traditional settings such as general practice. Data were obtained on consecutive individuals who commenced DAAs from March 2016 to June 2019. Effectiveness was assessed by sustained virological response ≥12 weeks following treatment (SVR) using intention-to-treat (ITT) and per-protocol (PP) analyses. Within REACH-C, 10,843 individuals initiated DAAs (male 69%; ≥50 years 52%; cirrhosis 22%). SVR data were available in 85% (9,174 of 10,843). SVR was 81% (8,750 of 10,843) by ITT and 95% (8,750 of 9,174) by PP. High SVR (≥92%) was observed across all service types and participant characteristics. Male gender (adjusted odds ratio [aOR] 0.56, 95% confidence interval [CI] 0.43-0.72), cirrhosis (aOR 0.52, 95% CI 0.41-0.64), recent injecting drug use (IDU; aOR 0.64, 95% CI 0.46-0.91) and previous DAA treatment (aOR 0.50, 95% CI 0.28-0.90) decreased the likelihood of achieving SVR. Multiple factors modified the likelihood of loss to follow-up including IDU ± opioid agonist therapy (OAT; IDU only: aOR 1.75, 95% CI 1.44-2.11; IDU + OAT: aOR 1.39, 95% CI 1.11-1.74; OAT only, aOR 1.36; 95% CI 1.13-1.68) and age (aOR 0.97, 95% CI 0.97-0.98). Conclusion: Treatment response was high in a diverse population and through a broad range of services following universal access to DAA therapy. Loss to follow-up presents a real-world challenge. Younger people who inject drugs were more likely to disengage from care, requiring innovative strategies to retain them in follow-up

Towards the elimination of dog-mediated rabies: development and application of an evidence-based management tool

Abstract: Background: International organizations advocate for the elimination of dog-mediated rabies, but there is only limited guidance on interpreting surveillance data for managing elimination programmes. With the regional programme in Latin America approaching elimination of dog-mediated rabies, we aimed to develop a tool to evaluate the programme’s performance and generate locally-tailored rabies control programme management guidance to overcome remaining obstacles. Methods: We developed and validated a robust algorithm to classify progress towards rabies elimination within sub-national administrative units, which we applied to surveillance data from Brazil and Mexico. The method combines criteria that are easy to understand, including logistic regression analysis of case detection time series, assessment of rabies virus variants, and of incursion risk. Subjecting the algorithm to robustness testing, we further employed simulated data sub-sampled at differing levels of case detection to assess the algorithm’s performance and sensitivity to surveillance quality. Results: Our tool demonstrated clear epidemiological transitions in Mexico and Brazil: most states progressed rapidly towards elimination, but a few regressed due to incursions and control lapses. In 2015, dog-mediated rabies continued to circulate in the poorest states, with foci remaining in only 1 of 32 states in Mexico, and 2 of 27 in Brazil, posing incursion risks to the wider region. The classification tool was robust in determining epidemiological status irrespective of most levels of surveillance quality. In endemic settings, surveillance would need to detect less than 2.5% of all circulating cases to result in misclassification, whereas in settings where incursions become the main source of cases the threshold detection level for correct classification should not be less than 5%. Conclusion: Our tool provides guidance on how to progress effectively towards elimination targets and tailor strategies to local epidemiological situations, while revealing insights into rabies dynamics. Post-campaign assessments of dog vaccination coverage in endemic states, and enhanced surveillance to verify and maintain freedom in states threatened by incursions were identified as priorities to catalyze progress towards elimination. Our finding suggests genomic surveillance should become increasingly valuable during the endgame for discriminating circulating variants and pinpointing sources of incursions