Guidance on Development of Employer Value Dashboards

Recent industry surveys indicate that a majority of employers are offering health and well-being (HWB) programs to their employees,1,2 but the reasons for offering them have changed over time. While a desire to improve employee health and contain rising health-care costs remain important, employers increasingly recognize a broader value proposition for investing in workforce HWB. A 2019 survey found employers are more likely to seek outcomes such as improved productivity and employee morale as well as reductions in injury rates and turnover.3 Demonstrating how workplace HWB initiatives are linked to such outcomes is challenging. As consultants, researchers, and practitioners working in the workplace wellness field for decades, we’ve often observed organizations that are benefits and data rich but information poor. Even when organizations invest in data warehouses and have access to sophisticated real-time reporting platforms, they struggle to organize the data into meaningful narratives that convey the value yielded by their investment. In 2018, Health Enhancement Research Organization (HERO) convened a large group of subject matter experts, employers, industry vendor suppliers, consultants, and practitioners to discuss how to approach measurement, evaluation, reporting, and dashboard development within their organization.4 A key point raised by several subject matter panelists was the need to identify who will be using the information that is shared and for what purpose. Additionally, the observation was made that there is a tremendous amount of time and energy invested in the development of client-specific dashboards and that a standardized approach and metrics would be of benefit to all involved. Therefore, the convening launched an effort focused on providing guidance for employers on development of a Value Demonstration Dashboard that informs decision-making regarding ongoing investments in workforce HWB. This article aims to share this guidance, with a focus on steps for development and identification of metrics that will be most meaningful for performance insight and informed decision-making by business leaders. But first, it’s important to clarify what we mean by a Value Demonstration Dashboard

Signal and Backgrounds for Leptoquarks at the LHC II: Vector Leptoquarks

We perform a detailed analyses of the CERN Large Hadron Collider (LHC) capability to discover first generation vector leptoquarks through their pair production. We study the leptoquark signals and backgrounds that give rise to final states containing a pair e+e- and jets. Our results show that the LHC will be able to discover vector leptoquarks with masses up to 1.3-2.1 TeV depending on their couplings to fermions and gluons.Comment: 18 pages, 3 figures, REVTe

Inhibition of interferon response by cystatin B: implication in HIV replication of macrophage reservoirs

Cystatin B and signal transducer and activator of transcription-1 (STAT-1) phosphorylation have recently been shown to increase human immunodeficiency virus-1 (HIV-1) replication in monocyte-derived macrophages (MDM), but the molecular pathways by which they do are unknown. We hypothesized that cystatin B inhibits the interferon (IFN) response and regulates STAT-1 phosphorylation by interacting with additional proteins. To test if cystatin B inhibits the IFN-β response, we performed luciferase reporter gene assays in Vero cells, which are IFN deficient. Interferon-stimulated response element (ISRE)-driven expression of firefly luciferase was significantly inhibited in Vero cells transfected with a cystatin B expression vector compared to cells transfected with an empty vector. To determine whether cystatin B interacts with other key players regulating STAT-1 phosphorylation and HIV-1 replication, cystatin B was immunoprecipitated from HIV-1-infected MDM. The protein complex was analyzed by liquid chromatography tandem mass spectrometry. Protein interactions with cystatin B were verified by Western blots and immunofluorescence with confocal imaging. Our findings confirmed that cystatin B interacts with pyruvate kinase M2 isoform, a protein previously associated cocaine enhancement of HIV-1 replication, and major vault protein (MVP), an IFN-responsive protein that interferes with JAK/STAT signals. Western blot studies confirmed the interaction with pyruvate kinase M2 isoform and MVP. Immunofluorescence studies of HIV-1-infected MDM showed that upregulated MVP colocalized with STAT-1. To our knowledge, the current study is the first to demonstrate the coexpression of cystatin B, STAT-1, MVP, and pyruvate kinase M2 isoform with HIV-1 replication in MDM and thus suggests novel targets for HIV-1 restriction in macrophages, the principal reservoirs for HIV-1 in the central nervous system

Multilepton Signatures for Leptoquarks

The production of third generation leptoquarks can give rise to multilepton events accompanied by jets and missing transverse energy. In this work we study the signals of these leptoquarks at the CERN Large Hadron Collider and compare them with the ones expected in supersymmetric models.Comment: 13 pages, 4 figure

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum