Free surface energy evaluation in the laser texturing of a carbon steel s275

Currently, the manufacture of hybrid structures of dissimilar materials is generating great interest. These allow to combine mechanical properties of different materials to achieve a higher functional performance. To obtain these structures, different joining technologies are used, especially the use of adhesives. Nevertheless, for the correct application of an adhesive, the surface of the metal to be bonded must be prepared. Laser texturing has become a widely studied technology for this purpose because it allows very defined textures to be obtained. This technology allows to activate the surface and improve the application of the adhesive afterwards. In that sense, hydrophilic surfaces are generated and evaluated by wettability tests to know the surface free energy obtained in the texturing. In order to improve the bonding of dissimilar materials in the form of hybrid structure, a study has been carried out on the laser texturing of a carbon steel S275 and the relationship between the texturing parameters with its surface activation through wettability and surface free energy tests. Thus, the energy density obtained by the combination of power and scanning speed allows the generation of very defined textures that increase the surface activation of the steel. This has made it possible to establish a mathematical relationship between the texturing parameters and the results obtained. © 2022 The Authors

PIAS4 is associated with macro/microcephaly in the novel interstitial 19p13.3 microdeletion/microduplication syndrome

Array comparative genomic hybridization (aCGH) is a powerful genetic tool that has enabled the identification of novel imbalances in individuals with intellectual disability (ID), autistic disorders and congenital malformations. Here we report a \u27genotype first\u27 approach using aCGH on 13 unrelated patients with 19p13.3 submicroscopic rearrangement (11 deletions and 2 duplications) and review cases in the literature and in public databases. Shared phenotypic features suggest that these patients represent an interstitial microdeletion/microduplication syndrome at 19p13.3. Common features consist of abnormal head circumference in most patients (macrocephaly with the deletions and microcephaly with the duplications), ID with developmental delay (DD), hypotonia, speech delay and common dysmorphic features. The phenotype is associated with at least a ~0.113 Mb critical region harboring three strong candidate genes probably associated with DD, ID, speech delay and other dysmorphic features: MAP2K2, ZBTB7A and PIAS4, an E3 ubiquitin ligase involved in the ubiquitin signaling pathways, which we hypothesize for the first time to be associated with head size in humans