Distribution of participant characteristics by case-control status.

*<p>ICC/Cancer subtype: 45 patients had squamous cell carcinoma; 3 had adenosquamous carcinomas.</p><p>High Risk HPV- 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68.</p><p>Low/Other Risk HPV – 6,11, 26, 40, 42, 55, 61, 62, 69, 70, 72, 73, 81, 82, 83, 84.</p

Adjusted odds ratios for the associations between mean DMR methylation for <i>PEG3</i>, HPV status and CIN and ICC.

*<p>Controlling for HIV-1 status, HPV positive status, age, and oral contraceptive (OC) use.</p><p>Per 5% methylation increase.</p

Validation of the <i>PEG3</i> pyrosequencing assay.

<p>Defined mixtures (x-axis) of methylated and unmethylated DNAs were prepared and analyzed in quintuplicate by pyrosequencing (y-axis). The results shown represent the mean; error bars indicate standard deviations. The Pearson rho is 0.953 with a p-value of 0.004.</p

Correlation between High and Low Risk HPV status and methylation fraction means at differentially methylated region (DMRs) of <i>PEG3</i>.

<p>High Risk HPV - 16,18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68.</p><p>Low/Other Risk HPV – 6, 11, 26,40, 42, 55, 61, 62, 69, 70, 72, 73, 81, 82, 83, 84.</p