15 research outputs found
Efficient Synthesis of Novel Tetrahydropyrrolo[30,40:3,4]Pyrrolo[2,1-a] Isoquinoline Derivatives via a Simple and Convenient MCR in Aqueous Micellar System
A simple and efficient one-pot three component synthesis of tetrahydropyrrolo[30,40:3,4]pyrrolo[2,1-
a]isoquinoline-9,11-dione derivatives has been achieved from variously substituted isoquinolines, 2-
bromo acetophenone and N-aryl maleimide derivatives in an aqueous micellar medium. The synthesis
represents an environmentally benign alternative to classical method
Synthesis and Characterization of Furo[3,2-h]Quinoliniums as Potent Non-Detergent Spermicides
7-Aryl substituted furo[3,2-h]quinoliniums have been synthesised in two steps from 5-chloro-8-hydroxy-7-
iodo-quinoline through a tandem Sonogashira alkynylation-cyclization pathway using aryl acetylenes followed by quaternisation reaction with alkyl halides under microwave irradiation. The compounds have been characterized spectroscopically and assessed for their sperm-immobilizing efficacy in vitro by modified Sander–Cramer test. Most of the derivatives showed potent spermicidal effect with minimum effective concentration (MEC) ranging from 125�g/ml – 1mg/ml. The results were further confirmed by double fluoroprobe staining with syber14/PI (Propidium Iodide). The mode of spermicidal action was assessed by (a) Hypo-osmotic swelling tests and (b) Scanning electron microscopy. The compounds have been found to be nontoxic to lactobacillus in 36 hours of culture whereas mild to moderately effective on common vaginal pathogens. Taken together it can be inferred that the water-soluble salts prepared from facile technique are potential candidates
for spermicides and could further be utilized for the preparation of vaginal contraceptives
Copper–phenanthroline catalysts for regioselective synthesis of pyrrolo[3′,4′:3,4]pyrrolo[1,2 a]furoquinolines/ phenanthrolines and of pyrrolo[1,2-a]phenanthrolines under mild conditions
A new series of pyrrolo[3′,4′:3,4]pyrrolo[1,2-a]furoquinolines/phenanthrolines and pyrrolo[1,2-a]phenanthrolines were efficiently
built up from an 8-hydroxyquinoline derivative or phenanthroline via 1,3-dipolar cycloaddition reaction involving non-stabilized
azomethine ylides, generated in situ from the parent furo[3,2-h]quinoliniums/phenanthroliums, in presence of a copper(II)
chloride–phenanthroline catalytic system. The methodology combines general applicability with high yields
Amberlite IRA 402(OH): An Efficient Mediator for the Exclusive Synthesis of Fused Tricyclic Oxaza Quinolinium Salts
A high yielding green protocol for the synthesis of tricyclic oxaza quinolinium salts has been developed
using Amberlite IRA 402(OH) in water. This method is more effective compared to previously reported
phase-transfer catalytic (PTC) condition in terms of yield of the product, reaction time and ease of
separation
Novel Route for the Synthesis of Structurally Diverse Pyrrolo[2,1-a]Isoquinoline in Aqueous Micellar Medium
A high yielding environmentally benign protocol has been developed for the synthesis of pyrrolo[2,1-
a]isoquinoline using chromone-3-carboxaldehyde, isoquinoline and phenacyl bromide/bromoacetic acid
ester as reagents in aqueous micellar medium. The method is operationally simple and more effective
compared to the previous methods in terms of the yield of the products as well as the reaction time
Molecular and Functional Studies of Tyrosinase Variants Among Indian Oculocutaneous Albinism Type 1 Patients
This article does not have an abstract
Synthesis and in Vitro Study of Antibacterial, Antifungal Activities of some Novel Bisquinolines
Efficient syntheses of a series of novel bisquinolines
have been accomplished from8-hydroxy quinolines under
phase transfer catalyzed conditions using tetrabutylamoniumbromide
as phase transfer catalyst. In vitro antibacterial and antifungal
study of the synthesized analogues revealed six of them to
show significant antibacterial and four to show significant antifungal
activity. Among them 3c and 6c show most significant
antibacterial activities with minimum inhibitory concentration
value 32 lg/mL against four bacterial strains. Ultra structural
studies of the microbes treated with 6c demonstrated deformation
of cell wall and cell agglomeration. The bisquinolines
exhibiting bacteriostatic or fungistatic activity may be developed
as newer antimicrobial agents