Performance of AshTest for the diagnosis (binary) and severity (ordinal) of alcoholic steatohepatitis (n = 123).

<p>AshTest had significant higher AUROCs than AST/ALT for all scores and lesions. NonBinROC is the Obuchowski measure, the non-binary estimate of ordinal test performance. AshTest had significant Obuchowski measures than AST/ALT for ASH scores and for PMN and Mallory.</p><p>Performance of AshTest for the diagnosis (binary) and severity (ordinal) of alcoholic steatohepatitis (n = 123).</p

Flow chart of inclusion.

<p>Flow chart of inclusion.</p

Concordance between ASH grades presumed by AshTest and by biopsy.

<p>The histological score is the sum of the 3 elementary lesion grades: Ballooning, PMN and Mallory bodies.</p><p>Concordance between ASH grades presumed by AshTest and by biopsy.</p

Comparison between included and non-included patients.

<p>¹One FibroTest was not reliable, and all AshTest were reliable</p><p>Comparison between included and non-included patients.</p

Area under the ROC curves (AUROC) of AshTest versus AST/ALT, Maddrey, and MELD scores.

<p>0.815 (0.639–0.910), 0.565 (0.348–0.725), 0.571 (0.448–0.730) and 0.537 (0.327–0.751) respectively, for the diagnosis of at least one histological features of alcoholic hepatitis. All comparisons were significant (P<0.01) between AshTest and AST/ALT, Maddrey and MELD scores.</p

Box Plots of Biomarkers according to liver injury.

<p>FibroTest according to fibrosis stage (Panel A), SteatoTest according to steatosis grade (Panel B), ActiTest according to NAS score (Panel C) to ballooning (Panel D) and inflammation (Panel E) in 494 patients. Notched box plots showing the relationship between tests and the stage/grade of liver injury. The horizontal line inside each box represents the median, and the width of each box the median±1.57 interquartile range/√n (to assess the 95% level of significance between group medians). Failure of the shaded boxes to overlap signifies statistical significance (P<0.05). The horizontal lines above and below each box encompass the interquartile range (from the 25th to 75th percentile), and the vertical lines from the ends of the box encompass the adjacent values (upper: 75th percentile plus 1.5 times interquartile range; lower: 25th percentile minus 1.5 times interquartile range).</p

Quantitative concordance between elasticity values and severity of fibrosis, adjusted by inflammation, and steatosis.

<p>The strength of concordance was assessed by the Lin concordance correlation coefficient. Fibrosis, Steatosis and Inflammation were assessed by FibroTest, ActiTest and SteatoTest respectively.</p

Applicability of fibrosis tests in investigated patients.

<p>Applicability of fibrosis tests in investigated patients.</p

Elasticity values according to inflammation, or steatosis, among patients with or without severe fibrosis (F3F4).

<p>(A) 2D-SWE elasticity according to inflammation. (B) TE-M elasticity according to inflammation. (C) TE-XL elasticity according to inflammation. (D) 2D-SWE elasticity according to steatosis. (E) TE-M elasticity according to steatosis. (F) TE-XL elasticity according to steatosis. If not impacted by inflammation or steatosis the curves should be flat. 2D-SWE was less impacted than TE-M.</p

Distribution of elasticity values according to different standardizations.

<p>Upper circles corresponded to severe outliers for whom elasticity values were outside boundaries defined as three times the inter-quartile range. (A) No transformation. (B) Log¹⁰ Transformation. (C) Log-transformation plus standardized according to the range of values (0-75kPa), from 0.00 to 1.00. (n = 1,588 for all tests except for ActiTest n = 1,270).</p