2 research outputs found
Patterns of failure following post-operative intensity-modulated radiotherapy in oral cavity cancer: Planning CT and Recurrence CT dataset
<p><i>Purpose of Original Study</i></p><p>We sought
to identify spatial/dosimetric patterns of failure for oral cavity cancer (OCC)
patients receiving post-operative intensity-modulated radiotherapy (PO-IMRT).</p><p><i>Material and Methods</i></p><p>289 OCC
patients receiving PO-IMRT from a single institution were retrospectively
reviewed from 2000-2012 with institutional review board approval. Diagnostic CT/PET-CT
documenting recurrence (rCT) was co-registered with original planning CTs (pCT)
using a validated deformable image registration (DIR) workflow. Manually
segmented recurrent gross disease (rGTV) on rCT was deformed to co-registered
pCTs. Mapped rGTVs were compared dosimetrically to planned dose and spatially
to original planning target volumes (TVs) using centroid-based approaches. Technical
details for the DIR workflow methodology are found in the references below.</p><p>We
classify failure using standardized institutional classification system
combining spatial/dosimetric criteria: A (central high dose), B (peripheral
high dose), C (central elective dose), D (peripheral elective dose), and E
(extraneous dose). Definitions of failure classifications are further described
in the references below. Of 63 patients with locoregional recurrences, 48
patients had available rCT and pCT for analysis. In this dataset of 48 patient
rCTs, 75 rGTVs were identified.</p><p><i>Purpose of Sharing Anonymized Dataset</i></p><p>We hope
that by utilizing a standardized typology for reporting patterns of failure in
OCC following PO-IMRT, which can be adopted by multiple institutions, we can
encourage other comparable reporting practices for PO-IMRT, in a manner that
allows improved detection of possible modes of preventable error; for this
reason, we are posting an anonymized archive of the extant dataset via digital
repository.</p><p>In this anonymized
fileset in DICOM format, we share the following:</p><p>1. Original pCTs of 48 patients, along with
original planning TVs</p><p>2. Prescribed dose to original pCTs</p><p>
</p><p>3. rCTs of 48 patients, along with the 75
rGTVs</p
Additional file 1: Table S1. of Long-term patient reported outcomes following radiation therapy for oropharyngeal cancer: cross-sectional assessment of a prospective symptom survey in patients ≥65 years old
Proportions of patients reporting moderate to severe (≥5) rating for the 22 MDASI-HN symptom items by clinical subgroups of interest. (DOCX 20 kb