107 research outputs found
ACTA PHYSICA POLONICA A MODIFIED KRATZER-FUES FORMULA FOR ROTATION-VIBRATION ENERGY OF DIATOMIC MOLECULES*
An extension of the Kratzer-Fues approach to analytical calculation of the rotation-vibration energy of diatomic molecules is proposed. The eigen -v a l u e s f r o m t h i s a p p r o a c h a r e a p p l i e d i n c a l c u l a t i o n o f t h e r o t a t i o n a l a n d rovibrational energies and in evaluation of molecular constants of selected diatomic molecules, resulting in satisfactory reproduction of experimental frequencies over a wide range of rotational states. In contrast to our previous proposition the rotational dependence of vibration energy is taken into account. An additional set of fitted parameters which include equilibrium distance and dissociation constant was also employed
Homeostatic competition drives tumor growth and metastasis nucleation
We propose a mechanism for tumor growth emphasizing the role of homeostatic
regulation and tissue stability. We show that competition between surface and
bulk effects leads to the existence of a critical size that must be overcome by
metastases to reach macroscopic sizes. This property can qualitatively explain
the observed size distributions of metastases, while size-independent growth
rates cannot account for clinical and experimental data. In addition, it
potentially explains the observed preferential growth of metastases on tissue
surfaces and membranes such as the pleural and peritoneal layers, suggests a
mechanism underlying the seed and soil hypothesis introduced by Stephen Paget
in 1889 and yields realistic values for metastatic inefficiency. We propose a
number of key experiments to test these concepts. The homeostatic pressure as
introduced in this work could constitute a quantitative, experimentally
accessible measure for the metastatic potential of early malignant growths.Comment: 13 pages, 11 figures, to be published in the HFSP Journa
Patient-Specific Prosthetic Fingers by Remote Collaboration - A Case Study
The concealment of amputation through prosthesis usage can shield an amputee
from social stigma and help improve the emotional healing process especially at
the early stages of hand or finger loss. However, the traditional techniques in
prosthesis fabrication defy this as the patients need numerous visits to the
clinics for measurements, fitting and follow-ups. This paper presents a method
for constructing a prosthetic finger through online collaboration with the
designer. The main input from the amputee comes from the Computer Tomography
(CT) data in the region of the affected and the non-affected fingers. These
data are sent over the internet and the prosthesis is constructed using
visualization, computer-aided design and manufacturing tools. The finished
product is then shipped to the patient. A case study with a single patient
having an amputated ring finger at the proximal interphalangeal joint shows
that the proposed method has a potential to address the patient's psychosocial
concerns and minimize the exposure of the finger loss to the public.Comment: Open Access articl
Self-organization of developing embryo using scale-invariant approach
<p>Abstract</p> <p>Background</p> <p>Self-organization is a fundamental feature of living organisms at all hierarchical levels from molecule to organ. It has also been documented in developing embryos.</p> <p>Methods</p> <p>In this study, a scale-invariant power law (SIPL) method has been used to study self-organization in developing embryos. The SIPL coefficient was calculated using a centro-axial skew symmetrical matrix (CSSM) generated by entering the components of the Cartesian coordinates; for each component, one CSSM was generated. A basic square matrix (BSM) was constructed and the determinant was calculated in order to estimate the SIPL coefficient. This was applied to developing <it>C. elegans </it>during early stages of embryogenesis. The power law property of the method was evaluated using the straight line and Koch curve and the results were consistent with fractal dimensions (fd). Diffusion-limited aggregation (DLA) was used to validate the SIPL method.</p> <p>Results and conclusion</p> <p>The fractal dimensions of both the straight line and Koch curve showed consistency with the SIPL coefficients, which indicated the power law behavior of the SIPL method. The results showed that the ABp sublineage had a higher SIPL coefficient than EMS, indicating that ABp is more organized than EMS. The fd determined using DLA was higher in ABp than in EMS and its value was consistent with type 1 cluster formation, while that in EMS was consistent with type 2.</p
Modified Kratzer-Fues Formula for Rotation-Vibration Energy of Diatomic Molecules
An extension of the Kratzer-Fues approach to analytical calculation of the rotation-vibration energy of diatomic molecules is proposed. The eigen-values from this approach are applied in calculation of the rotational and rovibrational energies and in evaluation of molecular constants of selected diatomic molecules, resulting in satisfactory reproduction of experimental frequencies over a wide range of rotational states. In contrast to our previous proposition the rotational dependence of vibration energy is taken into account. An additional set of fitted parameters which include equilibrium distance and dissociation constant was also employed
Expansion of the Rotational Energy of Diatomic Molecules into a Continued Fraction
A new expansion of the rotational energy of diatomic molecules, in the form of a continued fraction has been investigated. The considered formula is applied in calculation of molecular constants and reproduction of rotational spectra of rigid-, semirigid- and van der Waals-type molecules. A physical interpretation of semiempirical expansion parameters is proposed and a connection between the method considered and the Dunham approach is also discussed
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