14 research outputs found

    Et4NC2O4SnPh3.2SnPh3Cl and Cy2NH2C2O4SnPh3.2SnPh3Cl: Synthesis and Spectroscopic Characterization

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    Two trinuclear oxalate tin (IV) adducts have been synthesized and characterized by elemental analyses, infrared and Mössbauer techniques. The suggested structures are discrete, oligomeric or polymeric, the anion behaving as a monochelating and bidentate ligand in one case while being a tetracoordinating ligand in the second one. The environment of the tin centre is trigonal bipyramidal, the SnPh 3 residue being cis or trans coordinated

    From Topology to Phenotype in Protein–Protein Interaction Networks

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    We have recently witnessed an explosion in biological network data along with the development of computational approaches for their analyses. This new interdisciplinary research area is an integral part of systems biology, promising to provide new insights into organizational principles of life, as well as into evolution and disease. However, there is a danger that the area might become hindered by several emerging issues. In particular, there is typically a weak link between biological and computational scientists, resulting in the use of simple computational techniques of limited potential to explain these complex biological data. Hence, there is a danger that the community might view the topological features of network data as mere statistics, ignoring the value of the information contained in these data. This might result in the imposition of scientific doctrines, such as scale-free-centric (on the modelling side) and genome-centric (on the biological side) opinions onto this nascent research area. In this chapter, we take a network science perspective and present a brief, high-level overview of the area, commenting on possible challenges ahead. We focus on protein-protein interaction networks (PINs) in which nodes correspond to proteins in a cell and edges to physical bindings between the proteins. © 2010 Springer-Verlag London Limited

    Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

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    The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups’ new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases). © 2017, Serdi and Springer-Verlag France

    Erratum to: Building bridges for innovation in ageing: Synergies between action groups of the EIP on AHA

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    The authors would like to change and use the correct name of M. Khaitov which is M. Kaitov on this manuscript. The authors have incorrectly used her other name during the finalization of this research. With this, the authors hereby publish the correct author names as presented above. © 2016 Serdi and Springer-Verlag Franc

    Clinical pharmacology and therapeutics.

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