Results of the multipoint linkage analysis using MERLIN.

<p>Note: All linkage regions with a LOD score >1.5 at the peak marker in at least one of the multipoint analyses, nonparametric (NPL), dominant (DOM), or recessive (REC), are presented. The upper and lower bounds of each linkage peak interval presented were selected based on covering all markers with a LOD or HLOD score within one LOD score unit of the peak marker's LOD score. The peak LOD scores are indicated with <b>bold text</b>. Chr, chromosome; SNP, single nucleotide polymorphism; LOD, logarithm of the odds; HLOD, heterogeneity logarithm of the odds.</p

Worldwide distribution of the minor (risk) allele, G, of rs613872 in <i>TCF4.</i>

<p>Data from the Human Genome Diversity Project, available online through the UCSC genome browser at <a href="http://genome.ucsc.edu/" target="_blank">http://genome.ucsc.edu/</a>. Note the higher prevalence of the risk allele in sample populations from Europe, the Middle East, and Southern Asia and the absence of the risk allele in sample populations from Africa, Eastern Asia, and Central and South America.</p

Comparison of genotype frequencies between Duke dataset and dataset used in Baratz et al. (2010), and between male and female in Duke dataset for rs613872.

<p>*<b>N: total sample size.</b></p><p>**<b>Heterozygous frequencies are elevated in all datasets and are highlighted in bold.</b></p

Plot of the top multipoint linkage peak on chromosome 18.

<p>SNP markers are plotted along the x-axis by their deCODE map position, and the LOD/HLOD scores for each marker are plotted along the y-axis. The results of the FASTLINK/HOMOG dominant two-point analysis are indicated with black circles, and the results of the MERLIN dominant multipoint analysis are indicated with a black line. The SNP rs4941043 is the peak marker from the two-point analysis (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0018044#pone-0018044-t003" target="_blank"><b>Table 3</b></a>). The location of the <i>FCD2</i> peak (Sundin <i>et al.</i>, 2006) and the most significantly associated SNP, rs613872, from the FECD GWAS performed by Baratz <i>et al.</i> (2010) are indicated by arrows. The location of the <i>TCF4</i> gene is also indicated for reference. 2PT, two-point results; MPT, multipoint results; cM, centiMorgans; LOD, logarithm of the odds; HLOD, heterogeneity logarithm of the odds.</p